The role of FDG PET/CT discovering the cause of fever of unknown origin

2012 ◽  
Vol 153 (6) ◽  
pp. 227-231
Author(s):  
Bernadett Szűcs ◽  
Edit Nagy ◽  
Stefan Talev ◽  
Ildikó Garai ◽  
László Galuska
Keyword(s):  
Case Report ◽  
Fever Of Unknown Origin ◽  
Unknown Origin ◽  
Diagnostic Procedures ◽  
Clinical Problem ◽  
Diagnostic Techniques ◽  
Diagnostic Methods ◽  
Pet Ct ◽  
Fdg Pet Ct

The fever of unknown origin from time to time constitutes a serious clinical problem and nearly all diagnostic methods are involved to discover urgently its cause. According to literature data 18F-fluoro-deoxyglucose PET/CT was successful in 25-70% of cases even in patients without any positive findings with conventional diagnostic techniques. The Hungarian National Health Fund does not include fever of unknown origin in the list of reimbursed 18F-fluoro-deoxyglucose PET/CT indications. The authors try to illustrate the clinical problem with this case report. Fever of unknown origin persisted in a patient for a year, but conventional diagnostic procedures were unsuccessful to find the cause of the fever. Finally, 18F-fluoro-deoxyglucose PET/CT indicated a metabolically active focus between the pancreas tail and the spleen. After a long-lasting antibiotic therapy the patient became symptomfree. Orv. Hetil., 2012, 153, 227–231.

scholarly journals The Diagnostic Role of FDG PET/CT in Patients with Fever of Unknown Origin

2011 ◽  
Vol 20 (1) ◽  
pp. 19-25 ◽  
Author(s):  
Nurhan Ergül ◽  
Metin Halac ◽  
Tevfik F. Cermik ◽  
Resat Ozaras ◽  
Sait Sager ◽  
...  
Keyword(s):  
Fdg Pet ◽  
Fever Of Unknown Origin ◽  
Unknown Origin ◽  
Pet Ct ◽  
Diagnostic Role ◽  
Fdg Pet Ct

scholarly journals Role of FDG-PET/CT in children with fever of unknown origin

2020 ◽  
Vol 47 (6) ◽  
pp. 1596-1604 ◽  
Author(s):  
Jordy P. Pijl ◽  
Thomas C. Kwee ◽  
G.E. Legger ◽  
Helja J.H. Peters ◽  
Wineke Armbrust ◽  
...  
Keyword(s):  
Fdg Pet ◽  
Fever Of Unknown Origin ◽  
Unknown Origin ◽  
Pet Ct ◽  
Fdg Pet Ct

scholarly journals The Role of PET/CT in the Investigation of Fever of Unknown Origin

2020 ◽  
pp. 71-82
Author(s):  
Ioanna Kotsiri ◽  
Charalampos Panotopoulos ◽  
E. Magiorkinis
Keyword(s):  
Fdg Pet ◽  
Fever Of Unknown Origin ◽  
Imaging Techniques ◽  
Unknown Origin ◽  
Diagnostic Approach ◽  
Pet Ct ◽  
Detailed Medical History ◽  
18F Fdg ◽  
Fdg Pet Ct

Aims: Fever of unknown origin (FUO) remains a diagnostic challenge for clinicians. The current diagnostic approach includes a detailed medical history, physical examination, laboratory tests and imaging techniques (chest X-ray, ultrasound, CT, MRI). 18F-FDG PET/CT (18fluoro-deoxyglucose PET/CT) is a non-invasive diagnostic imaging technique, which is widely used in oncology. The purpose of our narrative review was to summarize the knowledge for the diagnostic role of 18F-FDG PET/CT in the diagnostic approach of patients with FUO, as reported in the literature. Methodology: We undertook a search of literature published in PubMed until February 2019. Results: Various studies showed that 18F-FDG PET/CT could play an important role as a second-line explorative technique in the diagnosis of patients with FUO. 18F-FDG PET/CT presents high diagnostic accuracy in large vessel vasculitis, in orthopedic prosthetic infections, in chronic osteomyelitis and in prosthetic valve endocarditis. However, 18 -FDG/PET has some limitations such as the assessment of urine tract due to the excretion into the urine but also become of the high glucose metabolism in some organs such as the brain. Conclusions: Overall, PET/CT gains increasing interest in the diagnosis of FUO and should be considered by the clinicians in the exploration of those patients.

scholarly journals FDG-PET or PET/CT in Fever of Unknown Origin: The Diagnostic Role of Underlying Primary Disease

2011 ◽  
Vol 2011 ◽  
pp. 1-8 ◽  
Author(s):  
Nurhan Ergül ◽  
Tevfik Fikret Çermik
Keyword(s):  
Fdg Pet ◽  
Fever Of Unknown Origin ◽  
Inflammatory Diseases ◽  
Unknown Origin ◽  
Structural Analog ◽  
Diagnostic Methods ◽  
Pet Ct ◽  
Diagnostic Role ◽  
The Impact

Fever of unknown origin (FUO) is generally defined as a fever greater than 38.3°C on several occasions during a period longer than 3 weeks for which the etiology behind cannot be diagnosed at the end of at least 1 week hospital stay. Conventional diagnostic methods are still not adequate to reveal underlying reason in approximately 50% of patients with FUO. In patients with certain diagnosis, three major categories are infections, malignancies, and noninfectious inflammatory diseases. Fluoro-18-fluoro-2-deoxy-D:-glucose (FDG) is a structural analog of 2-deoxyglucose and accumulates in malignant tissues but also at sites of infection and inflammation. For this reason, FDG PET or PET/CT has great advantage in understanding of underlying pathology in assessment of FUO. However, till today, there are limited studies about the role of FDG PET or PET/CT in evaluation of FUO. In this paper, the impact of FDG PET or PET/CT in the diagnostic work-up of FUO is described by data obtained from literature review.

scholarly journals Fever of Unknown Origin: The Role of 18F-FDG PET/CT

2008 ◽  
Vol 49 (12) ◽  
pp. 1980-1985 ◽  
Author(s):  
Z. Keidar ◽  
A. Gurman-Balbir ◽  
D. Gaitini ◽  
O. Israel
Keyword(s):  
Fdg Pet ◽  
Fever Of Unknown Origin ◽  
Unknown Origin ◽  
Pet Ct ◽  
18F Fdg ◽  
Fdg Pet Ct

Analysis of cost-effectiveness in the diagnosis of fever of unknown origin and the role of 18F-FDG PET–CT: A proposal of diagnostic algorithm

2012 ◽  
Vol 31 (4) ◽  
pp. 178-186 ◽  
Author(s):  
E.M. Becerra Nakayo ◽  
A.M. García Vicente ◽  
A.M. Soriano Castrejón ◽  
J.A. Mendoza Narváez ◽  
M.P. Talavera Rubio ◽  
...  
Keyword(s):  
Cost Effectiveness ◽  
Fdg Pet ◽  
Fever Of Unknown Origin ◽  
Unknown Origin ◽  
Diagnostic Algorithm ◽  
Pet Ct ◽  
18F Fdg ◽  
Fdg Pet Ct
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