scholarly journals Comparison of the anterior chamber parameters in the pseudoexfoliation syndrome, pseudoexfoliation glaucoma and primary open angle glaucoma patients

2017 ◽  
Vol 1 (3) ◽  
Author(s):  
M. Sinan Saricaoglu ◽  
Ahmet Karakurt ◽  
Mualla Hamurcu ◽  
Selcan Ekicier Acar
Keyword(s):  
Anterior Chamber ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Pseudoexfoliation Syndrome ◽  
Open Angle ◽  
Pseudoexfoliation Glaucoma

scholarly journals MicroRNA 125b overexpression in pseudoexfoliation syndrome

2019 ◽  
Author(s):  
Martyna Tomczyk-Socha ◽  
Dagmara Baczyńska ◽  
Joanna Przeździecka-Dołyk ◽  
Anna Turno-Kręcicka
Keyword(s):  
Environmental Factors ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Pseudoexfoliation Syndrome ◽  
Open Angle ◽  
Pseudoexfoliation Glaucoma ◽  
Anterior Lens Capsule ◽  
Non Coding Rnas ◽  
First Time

Abstract Background MicroRNAs (miRs) are small non-coding RNAs. Qin et al. described miR 125b was downregulated in cataract tissue when compared to a transparent lens. The aim of study was (1) to establish the expression of miR 125b in cataracts complicated by pseudoexfoliation syndrome /PEX/, glaucoma or pseudoexfoliation glaucoma and (2) to determine whether any environmental factors influence miR 125b expression. Methods Anterior lens capsule were obtained from 150 patients. The patients were selected for three groups: with PEX, primary open angle glaucoma, pseudoexfoliation glaucoma, with matched controls in the term of gender (cataract alone). qPCR expression of microRNA 125b was examined in every groups. Results Mean age of 150 patients was 75.18years (SD +/-9.12years). Investigation indicates for the first time, that miR 125b expression is significantly increased 3.33x in PEX group (p=0,046). A lower level of miR 125b (p=0,01) was found in patients who smoked compared to those who did not. Conclusions Our data reveal the possible role of miR 125b in pseudoexfoliation syndrome development. There are two possible interpretations of these results. Either the co-existence of PEX acts as a moderator of miR 125b expression in the anterior lens, or the increased expression of miR 125b can be a cause of PEX.

scholarly journals Comparison of Ocular Biometry between Primary Open Angle Glaucoma Patients and Normal subjects

2021 ◽  
Vol 13 (2) ◽  
pp. 62-68
Author(s):  
Nisha Manandhar ◽  
Chandni Pradhan ◽  
Purushottam Joshi ◽  
Prabha Subedi ◽  
Pranav Shrestha
Keyword(s):  
Anterior Chamber ◽  
Axial Length ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Anterior Chamber Depth ◽  
Control Group ◽  
Open Angle ◽  
K Value ◽  
The Difference ◽  
Glaucoma Group

Introduction: Glaucoma is one of the major causes of irreversible blindness. In Nepal, the most common type of Glaucoma seen is Primary Open Angle Glaucoma. There are many risk factors associated with Primary Open Angle Glaucoma. The main objective of the study was to compare ocular biometric parameters in patients diagnosed with Primary Open Angle Glaucoma and age matched controls. Material and methods: This is a hospital based cross sectional study done at Mechi Eye Hospital. The study included 137 cases of Primary Open Angle Glaucoma and 75 normal individuals as control.  Axial length (AL), anterior chamber depth (ACD), Keratometry ‘K’ value and Central Corneal Thickness (CCT) were measured. Mann – Whitney U test was used for statistical analysis. Results: Mean age in Primary Open Angle Glaucoma group was (55.25 ± 10.16 years) and in the control group was (60.96 ± 10.91 years). Axial length  in the Primary Open Angle Glaucoma group (23.16 ±1.19 mm) was deeper as compared to the control group (22.69 ±0.89 mm), the difference was statistically significant (p<0.001). Anterior chamber depth (ACD) was statistically deeper in the Primary Open Angle Glaucoma group (3.05 ±0.51 mm) as compared to the control group (2.86 ±0.46 mm), (p<0.01). Central corneal thickness (CCT) was thinner in the Primary Open Angle Glaucoma group (519.5 ±36.25 um) as compared to the control group (525.40 ±37.77 um) but the difference was not found to be statistically significant (p<0.19). K value in Primary Open Angle Glaucoma (7.54 ±0.41mm) was higher than age-matched controls (7.58 ± 0.33mm) but the difference was not statistically significant (p<0.79). Conclusion: Patients with Primary Open Angle Glaucoma had longer Axial length (AL) and deeper Anterior chamber depth (ACD) as compared to normal individuals.

Outcomes of micropulse transscleral cyclophotocoagulation in primary open-angle glaucoma, pseudoexfoliation glaucoma, and secondary glaucoma

2020 ◽  
pp. 112067212091423 ◽  
Author(s):  
Oya Tekeli ◽  
Helin Ceren Köse
Keyword(s):  
Intraocular Pressure ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Secondary Glaucoma ◽  
Open Angle ◽  
Pseudoexfoliation Glaucoma ◽  
Transscleral Cyclophotocoagulation ◽  
The Mean ◽  
Glaucoma Group

Purpose: The aim of this study is to compare the outcomes of micropulse transscleral cyclophotocoagulation between primary open-angle glaucoma, pseudoexfoliation glaucoma, and other types of secondary glaucoma. Methods: Outcomes of 96 consecutive patients with refractory, end-stage glaucoma treated with micropulse transscleral cyclophotocoagulation were retrospectively reviewed. Follow-up examinations were performed on a regular basis until 12 months postoperatively. Surgical successes were defined as maintaining intraocular pressure ⩽18 mmHg and ⩾20% reduction in intraocular pressure (criteria A), ⩽15 mmHg intraocular pressure and ⩾25% reduction in intraocular pressure (criteria B), and ⩽12 mmHg intraocular pressure and ⩾30% reduction in intraocular pressure from baseline (criteria C). Results: Ninety-six eyes of 96 patients (50 (52%) females, 46 (48%) males) were included. Among all eyes, 32 were primary open-angle glaucoma, 30 were pseudoexfoliation glaucoma, and 34 were other types of secondary glaucoma. The mean age was 59.37 ± 11.45 (range: 20–91) years. The mean follow-up period was 14.2 ± 3.9 (range: 12–16) months. At 12 months, the success rates of primary open-angle glaucoma, pseudoexfoliation glaucoma, and secondary glaucoma group were 68.75%, 66.6%, and 64.7% (p = 0.185) for criteria A; 56.25%, 53.3%, and 50% (p = 0.153) for criteria B; and 43.75%, 43.3%, and 38.2% (p = 0.146) for criteria C. Four patients (12.5%) in primary open-angle glaucoma group, 5 patients (16.6%) in pseudoexfoliation glaucoma group, and 14 (41.2%) patients in other secondary glaucoma group required reoperation during the follow-up (p < 0.05). Conclusion: Micropulse transscleral cyclophotocoagulation is an equally effective method of lowering intraocular pressure in patients with primary open-angle glaucoma, pseudoexfoliation glaucoma, and other types of secondary glaucoma. The rate of reoperation was higher in refractory secondary glaucoma patients.

Sign in / Sign up

Export Citation Format

Share Document