scholarly journals Features of heart remodeling in patients with obstructive sleep apnea syndrome and its comorbid association with obesity in the context of the senilism concept

2019 ◽  
pp. 27-34
Author(s):  
T. O. Brodovskaya ◽  
O. O. Grishchenko ◽  
I. F. Grishina ◽  
T. F. Peretolchina
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Obstructive Sleep Apnea Syndrome ◽  
Sleep Apnea Syndrome ◽  
Biological Age ◽  
Control Group ◽  
Heart Remodeling ◽  
Obstructive Sleep ◽  
Functional Features ◽  
Apnea Syndrome

Aim. To analyze heart remodeling features in with obstructive sleep apnea syndrome and its association with obesity in the context of early cardiac aging.Material and methods. The study included 101 men, 41 patients with obstructive sleep apnea (OSA), 30 comorbid patients with OSA and obesity, the control group consisted of 30 healthy people. The average passport age of the patients was 40,4±6,7 years. Evaluation of OSA was carried out by cardiorespiratory monitoring, structural and functional features of the heart condition were studied using the echocardiography method, the average biological age was calculated.Results. Patients of both studied groups were characterized by structural and geometric rearrangement of the left heart chambers, transformation of physiological ellipsoid model into a spherical (left ventricle (LV) sphericity index 0,64±0,07 in the control group, 1,09±0,03 in the OSA group, 1,01±0,03 in the OSA + obesity group, p<0,05), LV hypertrophy (LV myocardial mass index was 78,1±23,9 in the group of healthy individuals, 98,1±11,4 in the OSA group and 116,0±29,4 in the OSA + obesity group, p<0,01). Systolic function in both study groups was preserved however, a tendency to stress of adaptive remodeling mechanisms was revealed. In addition, diastolic dysfunction was detected in both groups, in OSA group was associated with elasticity of the LV wall decrease, and in the OSA + obesity group, both with a violation of elasticity and an increase in the LV wall stiffness. The biological age of patients with OSA is 14% higher than the passport age, and with the association of OSA and obesity, by 39%.Conclusion. The obtained data prove impact of respiratory sleep disorders at heart remodeling as well as increased biological age. At the same time, the association of OSA with obesity has an additive adverse effect on the remodeling processes and the biological age of patients.

scholarly journals Alterations in Parafoveal and Optic Disc Vessel Densities in Patients with Obstructive Sleep Apnea Syndrome

2020 ◽  
Vol 2020 ◽  
pp. 1-9 ◽  
Author(s):  
Turgay Ucak ◽  
Ethem Unver
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Obstructive Sleep Apnea Syndrome ◽  
Sleep Apnea Syndrome ◽  
Foveal Avascular Zone ◽  
Control Group ◽  
Ophthalmological Examination ◽  
Rnfl Thickness ◽  
Obstructive Sleep ◽  
Apnea Syndrome

Purpose. To analyze the effects of obstructive sleep apnea syndrome (OSAS) on ocular parameters and determine the alterations in macular vasculature by optical coherence tomography-angiography (OCT-A) in patients with different stages of OSAS. Methods. All the participants underwent a full ophthalmological examination. Using the macular OCT-A scans, the retinal peripapillary capillary plexus (RPCP), foveal avascular zone (FAZ), and superficial and deep vessel densities were recorded. Results. A total of 77 patients (154 eyes) with OSAS and 27 control cases (54 eyes) were included in this prospective study. Of the OSAS patients, 27 had mild, 24 had moderate, and 26 had severe disease. The intraocular pressure (IOP) values were significantly higher in the severe OSAS group than the control cases (p=0.001). The average retinal nerve fiber layer (RNFL) thickness and the RNFL thickness of the temporal and inferior quadrants were significantly lower in the severe OSAS group compared with the control cases (p<0.05). There was a significant decrease in the mean RPCP values with a significant increase in the FAZ values of OSAS patients compared with the control group (p=0.001). Both the superficial and deep vascular densities were significantly decreased in OSAS patients, being the lowest in the severe OSAS group. Conclusions. Decreased vascular structures and increased FAZ may also be associated with the disease severity in OSAS and may be the main pathophysiological mechanisms in ocular alterations, which should be investigated in further studies.

Metamemory Beliefs and Episodic Memory in Obstructive Sleep Apnea Syndrome

2010 ◽  
Vol 107 (1) ◽  
pp. 289-302 ◽  
Author(s):  
Agnès Daurat ◽  
Nathalie Huet ◽  
Michel Tiberge
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Episodic Memory ◽  
Obstructive Sleep Apnea Syndrome ◽  
Memory Performance ◽  
Sleep Apnea Syndrome ◽  
Control Group ◽  
Obstructive Sleep ◽  
Subjective Sleepiness ◽  
Apnea Syndrome

This study assessed metamemory and its role in actual episodic memory performance in 26 patients with obstructive sleep apnea syndrome and 27 healthy controls. Metamemory knowledge and memory beliefs were assessed using the Metamemory Inventory in Adulthood. Episodic memory performance was investigated with the Remember/Know paradigm. Subjective sleepiness was evaluated. Patients underwent a polysomnographic assessment. In contrast to the control group's more stable memory beliefs, patients self-assessed their memory as declining across time, and felt more anxious about their memory. There was only a modest difference between patients' self-perceptions of their memory capacities and those of the control group, but patients' actual memory performance was strongly disturbed. While the later was significantly correlated with severity of obstructive sleep apnea, scores on the Metamemory Inventory in Adulthood scales were not correlated with physiological measures, subjective sleepiness, or episodic memory performance. Obstructive sleep apnea may affect prefrontal cortex functioning and hence the ability to assess one's own memory impairment.

scholarly journals The Effect of Vitamin C Therapy Towards Malondialdehyde Plasma Content on Chronic Tonsillitis Patients With Risk of Obstructive Sleep Apnea Syndrome

2018 ◽  
Vol 10 (9) ◽  
pp. 97
Author(s):  
Sutji Pratiwi Rahardjo Hiro ◽  
Hiro Salomo Mangape ◽  
Abdul Qadar Punagi ◽  
Andi Nilawati Usman
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Vitamin C ◽  
Obstructive Sleep Apnea Syndrome ◽  
Sleep Apnea Syndrome ◽  
Chronic Tonsillitis ◽  
Control Group ◽  
Obstructive Sleep ◽  
Significant Difference ◽  
Apnea Syndrome

INTRODUCTION: Sleep Apnea Syndrome is a syndrome with an episode of apnea or hypopnea during sleep. The objective of this study was to investigate the effect of the vitamin C therapy to plasma Malondialdehyde (MDA) level in patients with chronic tonsillitis who have a risk factor of Obstructive Sleep Apnea Syndrome (OSAS), measured pre and post-therapy.METHODS: The design of this study was a clinical trial with pre-test and post-test control group. This study was conducted in Dr. Wahidin Sudirohusodo Hospital and Hasanuddin University Teaching Hospital in Makassar and 30 subjects was enrolled (20 subjects were patients with chronic tonsillitis and OSAS, and 10 subjects were control). The measurement of plasma MDA level was obtained using ELISA method. The data were analyzed using the Mann-Whitney test and Chi-square test.RESULTS: The results of this study showed a decreasing level of plasma MDA in patients with chronic tonsillitis and OSAS after the vitamin C therapy. However, there was no significant difference between patients who had not received vitamin C therapy.CONCLUSION: The intervention of vitamin C in chronic tonsillitis patients and can reduce levels of plasma MDA.

scholarly journals Can Monocyte to HDL Ratio be a new Marker for Severity of Obstructive Sleep Apnea Syndrome?

2020 ◽  
pp. 1-4
Author(s):  
Aida Mahmoud Yousef ◽  
◽  
Jehan J El-Jawhari ◽  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Obstructive Sleep Apnea Syndrome ◽  
Sleep Apnea Syndrome ◽  
Hdl Cholesterol ◽  
Control Group ◽  
Monocyte Count ◽  
Cholesterol Ratio ◽  
Obstructive Sleep ◽  
Apnea Syndrome

Background: This study aimed to investigate the relation of serum monocyte to serum HDL cholesterol ratio (MHR) with obstructive sleep apnea syndrome (OSAS). A total of 62 patients with an apnea hypopnea index (AHI > 5) and excessive daytime sleepiness were included in this study as OSAS group. The individuals with (AHI) < 5/h were included in the study as controls. OSAS patients were compared with the control group for high density lipoprotein (HDL) levels, serum monocyte count, and monocyte to HDL ratio (MHR). Mild, moderate and severe OSAS subgroups were compared for the same parameters. Results: MHR was 11.93 ± 6.52 in the control group while it was 14.87 ± 6.98 in OSAS group, with a statistically significant difference in between them (p= 0.016). The MHR were positively correlated with AHI and the minimum oxygen saturation (p = 0.003 and p = 0.012, respectively). Conclusion: serum monocyte to serum HDL cholesterol ratio increased as OSAS severity increased. MHR is an easy and available biomarker. It can be used as a new marker for severity of OSAS

scholarly journals CLINICAL AND FUNCTIONAL PECULIARITIES OF COMORBID OBSTRUCTIVE SLEEP APNEA SYNDROME AND ASTHMA

2019 ◽  
Vol 1 (71) ◽  
pp. 23-30
Author(s):  
Елизавета Шелудько ◽  
Elizaveta Shelud'ko ◽  
Денис Наумов ◽  
Denis Naumov ◽  
Анна Приходько ◽  
...  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Obstructive Sleep Apnea Syndrome ◽  
Sleep Apnea Syndrome ◽  
Lung Diffusion ◽  
Diffusion Capacity ◽  
Timely Diagnosis ◽  
Obstructive Sleep ◽  
Functional Features ◽  
Apnea Syndrome

Obstructive sleep apnea syndrome (OSAS) is a pathogenetically heterogeneous condition that aggravates the course of asthma. For this reason, timely diagnosis and treatment of OSAS may improve asthma control, reduce the number of exacerbations and the frequency of short-acting bronchodilators use. The aim of the study was to describe the clinical and functional features of patients with asthma and OSAS, and to identify risk factors that allow suspecting the comorbidity. A total of 194 patients with asthma were examined. The research methods included assessment of symptoms using the ACT questionnaire, spirometry with bronchoprovocational tests, body plethysmography and determination of lung diffusion capacity, analysis of the cellular composition of induced sputum, echocardiography, overnight cardiorespiratory monitoring. According to the results of cardio-respiratory monitoring OSAS of varying severity was detected in 33% of patients (n=65). Epworth sleepiness scale did not allow specific discrimination of OSAS among the examined patients. In general, patients with the comorbid pathologies were more often men of older age groups, they had a long history of disease and smoking. In patients with OSAS diabetes and cardiovascular diseases were more common in the structure of concomitant pathology. The presence of OSAS did not significantly affect spirometry but was associated with a pronounced airway hyperresponsiveness regardless of the provocative stimulus. In addition, a higher airway resistance and an increase in lung diffusion capacity were noted in OSAS patients. Neutrophilic phenotype of inflammation was three times more common in case of concomitant OSAS, and signs of cardiac remodeling and an increase in pulmonary artery pressure were also observed in these patients. Thus, knowledge of the above features of asthma-OSAS phenotype will facilitate timely diagnosis and optimal therapeutic care for patients with a combination of pathologies.

scholarly journals Defining Safety Space for Functional Tongue Surgery in Korean Male Obstructive Sleep Apnea Syndrome Patients; Analysis on Spatial Relation of the Tongue and the Lingual Artery

2021 ◽  
Vol 64 (9) ◽  
pp. 641-651
Author(s):  
Marn Joon Park ◽  
Young Jun Choi ◽  
Yong Seok Lee ◽  
Yoo-Sam Chung
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Obstructive Sleep Apnea Syndrome ◽  
Reference Point ◽  
Sleep Apnea Syndrome ◽  
Spatial Relation ◽  
Lingual Artery ◽  
Control Group ◽  
Obstructive Sleep ◽  
Apnea Syndrome

Background and Objectives Upon operation of the tongue base for obstructive sleep apnea syndrome (OSAS), the lingual artery and the hypoglossal nerve are put at risk of injury, resulting in fatal complications such as massive bleeding upon damage. We studied the course of lingual artery in its relation with the tongue in OSAS patients and compared it with the age-and- gender-matched normal population.Subjects and Method Korean male patients confirmed with OSAS by polysomnography, including those who had contrast-enhanced computed tomography (ceCT) of the head and neck, were defined as “OSAS group.” Patients who had their ceCT image during the same study period were defined as the “control group.” The control group was paired with the OSAS group by age and sex. By using foramen cecum (FC) as the main reference point, four reference marks were defined. For each reference point, the distance between both lingual arteries and the depth of the lingual artery from the lingual surface of the tongue were evaluated. Results The depth of the lingual artery from the lingual surface of the tongue in the OSAS group (25.1±8.6 mm) was significantly different from the control (29.5±5.9 mm) at 1 cm anterior to the FC level (p<0.014). The width of both lingual arteries was narrower in the OSAS group (20.9±2.9) than in the control (24.3±6.1) at the FC level (p<0.003). Conclusion The course of lingual artery and its spatial relation with the tongue in Korean male OSAS patients differs from the matched normal population.

scholarly journals Obstructive sleep apnea syndrome: functional state of vascular endothelium and features of brain hemodynamics

2020 ◽  
Vol 17 (3) ◽  
pp. 329-336
Author(s):  
E. K. Yushkevich ◽  
N. P. Mitkovskaya ◽  
E. A. Grigorenko
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Obstructive Sleep Apnea Syndrome ◽  
Regional Cerebral Blood Flow ◽  
Sleep Apnea Syndrome ◽  
Control Group ◽  
Regional Cerebral Blood ◽  
Obstructive Sleep ◽  
Working Age ◽  
Apnea Syndrome

The aim of the study is to identify the relationships between the functional state of vascular endothelium and regional cerebral blood flow in people of working age with moderate to severe obstructive sleep apnea syndrome. A transverse prospective observational study was conducted. It included 24 patients. Among them were 16 patients of working age with moderate to severe obstructive sleep apnea syndrome who were included in the main study group and 8 patients without sleep disorders in the control group according to polysomnography. The levels of biochemical markers of endothelial dysfunction, the indicators of endothelium-dependent vasodilation of the brachial artery were determined. Single-photon emission computed tomography of the brain was performed using 99mTc-hexamethylpropyleneaminoxime. In the patients of working age with moderate to severe obstructive sleep apnea syndrome, significantly lower average group values of the serum nitric oxide level of 11.7 (6.25‒18.30) μmol/l were detected versus 34.4 (25.33‒41.70) μmol/l in the control group, p  < 0.01), as well as higher homocysteine concentrations of 19.4 (15.13‒23.76) μmol/l versus 11.6 (6.40‒ 14.71) μmol/l in the control group, p < 0.05, sP-selectin 176 (142.0‒189.0) ng/ml versus 122 (113.3‒168.5) ng/ml in the control group, p < 0.05, and sE β-selectin 78 (69.0‒121.0) ng/ml versus 52 (43.1‒73.3) ng/ml in the control group, p < 0.05. The data on the correlation of the level of neurohumoral markers of endothelial dysfunction of sP-selectin (p <  0.01) and sE-selectin (p < 0.05) with the degree of impaired regional cerebral blood flow were obtained. A direct relationship was found between the markers of endothelium-dependent vasodilation and regional cerebral blood flow in the frontal segments (p < 0.05), the temporal segment on the right (p < 0.05).

scholarly journals Adenosine Diphosphate-Induced Platelets Aggregability in Polysomnographically Verified Obstructive Sleep Apnea

2015 ◽  
Vol 23 (4) ◽  
pp. 360-366 ◽  
Author(s):  
Wael Alkhiary ◽  
Nesreen E. Morsy ◽  
Aida M. Yousef ◽  
Amr Mohamed El-Saddik ◽  
Eman O. Arram
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Obstructive Sleep Apnea Syndrome ◽  
Sleep Apnea Syndrome ◽  
Adenosine Diphosphate ◽  
Control Group ◽  
Activated Platelets ◽  
Obstructive Sleep ◽  
Platelet Aggregates ◽  
Apnea Syndrome

Obstructive sleep apnea syndrome (OSAS) is a risk factor for arterial thrombosis and cardiovascular morbidity. Activated platelets play key roles in the development of atherothrombosis, thus may be involved in these complications of OSAS. Herein, we evaluated the relationship between severity of OSAS and the degree of platelet aggregates as a marker of activated platelets in 64 patients with OSAS. Platelet aggregations were determined by means of optical aggregometry, using adenosine diphosphate (ADP) as an agonist. Compared with the control group, ADP-induced platelet aggregability was increased in patients with total OSAS, severe OSAS, and in mild to moderate OSAS. Moreover, ADP-induced platelet aggregation was correlated with the Epworth sleepiness scale (ESS) in patients with severe OSAS. Obstructive sleep apnea syndrome is associated with enhanced platelets aggregations, which may predispose the cardiovascular sequels. The ESS may be important in predicting platelet activation and thus atherothrombotic complications in those with OSAS.

Postoperative monitoring of children with obstructive sleep apnea syndrome

2014 ◽  
Vol 155 (18) ◽  
pp. 703-707 ◽  
Author(s):  
Pálma Benedek ◽  
Gabriella Kiss ◽  
Eszter Csábi ◽  
Gábor Katona
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Obstructive Sleep Apnea Syndrome ◽  
Preoperative Evaluation ◽  
Sleep Apnea Syndrome ◽  
Study Patient ◽  
Severe Obstructive Sleep Apnea ◽  
Obstructive Sleep ◽  
Significant Difference ◽  
Apnea Syndrome

Introduction: Treatment of pediatric obstructive sleep apnea syndrome is surgical. The incidence of postoperative respiratory complications in this population is 5–25%. Aim: The aim of the authors was to present the preoperative evaluation and monitoring procedure elaborated in Heim Pál Children Hospital, Budapest. Method: 142 patients were involved in the study. Patient history was obtained and physical examination was performed in all cases. Thereafter, polysomnography was carried out, the severity of the obstructive sleep apnea syndrome was determined, and the patients underwent tonsilloadenotomy. Results: 45 patients with mild, 50 patients with moderate and 47 patients with severe obstructive sleep apnea syndrome were diagnosed. There was no complication in patients with mild disease, while complications were observed in 6 patients in the moderate group and 24 patients in the severe group (desaturation, apnea, stridor, stop breathing) (p<0.000). In patients with severe obstructive sleep apnea syndrome, no significant difference was noted in preoperative apnoea-hypapnea index (p = 0.23) and in nadir oxygen saturation values (p = 0.73) between patients with and without complication. Conclusions: Patients with severe obstructive sleep apnea syndrome should be treated in hospital where pediatric intensive care unit is available. Orv. Hetil., 2014, 155(18), 703–707.

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