scholarly journals Effect of selective β-adrenoceptor blockade and surgical resection of the celiac-superior mesenteric ganglion complex on delayed liquid gastric emptying induced by dipyrone, 4-aminoantipyrine, and antipyrine in rats

Author(s):  
A.M. Vinagre ◽  
E.F. Collares
1988 ◽  
Vol 255 (2) ◽  
pp. G242-G246 ◽  
Author(s):  
H. E. Raybould ◽  
Y. Tache

The pathway by which cholecystokinin octapeptide (CCK-8) inhibits motility of the proximal stomach and the role of this pathway in the CCK-induced delay in gastric emptying of a liquid meal has been studied in rats by selective destruction of vagal afferent C-fibers using bilateral perineural application of the sensory neurotoxin, capsaicin, 3 or 4 days prior to the experiment. The capsaicin treatment significantly attenuated the decrease in intragastric pressure in urethan-anesthetized rats in response to CCK-8 (0.1-100 pmol iv) compared with vehicle-treated controls. Removal of the celiac-superior mesenteric ganglion completely abolished the inhibitory action of CCK-8 on gastric motility in these rats. In contrast, only celiac ganglionectomy in combination with vagotomy abolished the CCK-8 effect in vehicle-treated controls. Intravenous injection of CCK-8 (300 pmol) 5 min before intragastric administration of a methylcellulose solution decreased gastric emptying by 55% in conscious control or vehicle-treated rats. Perivagal capsaicin treatment abolished the delay in gastric emptying induced by CCK-8. In addition, capsaicin treatment alone significantly increased gastric emptying. These results demonstrate that CCK-8 decreases gastric motility in the gastric corpus and delays gastric emptying by a capsaicin-sensitive vagal afferent pathway. These same afferent fibers may also play a physiological role in the gastric emptying of liquids.


2001 ◽  
Vol 120 (5) ◽  
pp. A465-A465
Author(s):  
D PINTO ◽  
M GIOVANNAMARRA ◽  
V STANGHELLINI ◽  
M MARENGO ◽  
N MONETTI ◽  
...  

2001 ◽  
Vol 120 (5) ◽  
pp. A423-A423
Author(s):  
R CIANCI ◽  
G CAMMAROTA ◽  
A GASBARRINI ◽  
J GALLI ◽  
S AGOSTINO ◽  
...  

2000 ◽  
Vol 42 (9) ◽  
pp. 580-590 ◽  
Author(s):  
Ruth Nass ◽  
Leslie Boyce ◽  
Fern Leventhal ◽  
Beth Levine ◽  
Jeffrey Allen ◽  
...  

VASA ◽  
2011 ◽  
Vol 40 (4) ◽  
pp. 327-332 ◽  
Author(s):  
Gabrielli ◽  
Rosati ◽  
Vitale ◽  
Millarelli ◽  
Siani ◽  
...  

Venous aneurysms are uncommon but they can have devastating consequences, including pulmonary embolism, other thromboembolic events and death. We report six cases of venous aneurysm of the extremities, in which the first sign of presence was acute pulmonary embolism. Surgical resection is recommended whenever possible. Our experience suggests that prophylactic surgery is cautiously recommended for low-risk patients with venous aneurysms of the abdomen and strongly recommended for extremity deep and superficial venous aneurysms for their potential risk of developing thromboembolic complications despite adequate anticoagulation. Other venous aneurysms should be excised only if they are symptomatic or enlarging.


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