scholarly journals Imiquimod 5% cream in the treatment of superficial and nodular basal cell carcinomas: study of 10 cases

2002 ◽  
Vol 77 (6) ◽  
pp. 693-698 ◽  
Author(s):  
Cyro Festa Neto
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Topical Treatment ◽  
Imiquimod Cream ◽  
Basal Cell Carcinomas ◽  
Different Types

BACKGROUND: Topical treatment with 5% imiquimod cream has been demonstrated to be effective in patients with basal cell carcinoma. OBJECTIVES: In the present study, efficacy and tolerability of this treatment was analyzed in 10 patients with 13 different types of superficial and nodular basal cell carcinomas. METHODS: Imiquimod cream was applied daily for a mean period of 23 days. RESULTS AND CONCLUSIONS: All patients responded favorably to the drug with healing of the lesions. No recurrence was observed during two to three months of follow up.

scholarly journals Topical Treatment of Basal Cell Carcinomas in Nevoid Basal Cell Carcinoma Syndrome with a Smoothened Inhibitor

2011 ◽  
Vol 131 (8) ◽  
pp. 1735-1744 ◽  
Author(s):  
Hans Skvara ◽  
Frank Kalthoff ◽  
Josef G. Meingassner ◽  
Barbara Wolff-Winiski ◽  
Heinrich Aschauer ◽  
...  
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Topical Treatment ◽  
Basal Cell Carcinomas

Basal Cell Carcinoma of the Periocular Region

1998 ◽  
Vol 2 (4) ◽  
pp. 205-208 ◽  
Author(s):  
John P. Arlette ◽  
Alastair Carruthers ◽  
William J. Threlfall ◽  
Laurence M. Warshawski
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Mohs Micrographic Surgery ◽  
Micrographic Surgery ◽  
Upper Eyelid ◽  
Lateral Canthus ◽  
Significant Difference ◽  
Basal Cell Carcinomas

Background: Basal cell carcinomas of the periocular area present a particular challenge because of the likelihood of damage to vital structures. Objective: More than 10-years experience of treating basal cell carcinomas by Mohs micrographic surgery was reviewed. Methods: Chart analysis of 233 periocular basal cell carcinomas was performed. All patients were contacted either in clinical follow-up or by telephone review. Results: Two hundred and thirty-three periocular basal cell carcinomas were analyzed out of a total of 3,192 basal cell carcinomas treated during this period (7.3%). Patients ranged in age from 17 to 102 years with a mean age of 58.8 years and a median of 59.0 years. Of the patients, 54.5% were female. Mohs micrographic surgery was the prime therapy in 177 patients (75.9%). Of the lesions, 48.5% occurred in the medial canthal area, 35.2% on the lower eyelid, 10.7% on the upper eyelid, and 5.6% on the lateral canthus. There was no significant difference between the left/right distribution in males and females. The average follow-up time was 34 months (standard deviation 26.38 months). A cumulative rate of no recurrence tabulated by modified life table analysis was 0.9864. Conclusion: This study further documents the problems associated with basal cell carcinoma of the periocular area as well as the value of Mohs micrographic surgery as treatment.

Relation of the eighth edition of the American Joint Committee on Cancer staging system with histological risk classification for primary eyelid basal cell carcinoma

2020 ◽  
pp. 112067212092245
Author(s):  
Gustavo Savino ◽  
Giulio Volpe ◽  
Gabriela Grimaldi ◽  
Remo Battendieri ◽  
Giulia Midena ◽  
...  
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Staging System ◽  
Cancer Staging ◽  
Risk Classification ◽  
American Joint Committee ◽  
Basal Cell Carcinomas ◽  
Eighth Edition

Purpose: To investigate the relation between the eighth edition of the American Joint Committee on Cancer staging system and histological risk classification for primary eyelid basal cell carcinoma. Methods: Retrospective, observational case series of patients undergoing excisional biopsy for primary eyelid basal cell carcinoma in two tertiary centres between 2008 and 2018. Patients with <6 months of follow-up were excluded. Outcomes measured included histological subtype, American Joint Committee on Cancer 7 and 8 staging. Results: A total of 222 cases were included over a 10-year period, with a mean (range) follow-up of 25.74 (6–120) months and a median (range) age of 70 (28–93) years. According to American Joint Committee on Cancer 8, the most common T category was T1a (64%), followed by T1b (18%) and T2a (8%). Of the 222 specimens, 183 (82.43%), 17 (7.66%), 19 (8.56%) and 3 (1.35%) were staged as IA, IB, IIA and IIB, respectively. The most common histological subtype was nodular in IA category and infiltrative in categories IB and IIA. Histologically, low-risk basal cell carcinomas were related to lower American Joint Committee on Cancer staging (IA), whereas high-risk basal cell carcinomas were related to American Joint Committee on Cancer stages IB and IIA (p < 0.001). No significant relation was found between T categorisation and risk stratification when adopting American Joint Committee on Cancer 7. Conclusion: American Joint Committee on Cancer 8 staging system is strongly related to primary eyelid basal cell carcinoma histological risk classification.

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