scholarly journals Cholesterol improves the transfection efficiency of polyallylamine as a non-viral gene delivery vector

2017 ◽  
Vol 53 (3) ◽  
Author(s):  
Reza Kazemi Oskuee ◽  
Mahdieh Ramezanpour ◽  
Leila Gholami ◽  
Bizhan Malaekeh-Nikouei
Keyword(s):  
Gene Delivery ◽  
Transfection Efficiency ◽  
Viral Gene ◽  
Gene Delivery Vector ◽  
Delivery Vector ◽  
Viral Gene Delivery

ORMOSIL nanoparticles as a non-viral gene delivery vector for modeling polyglutamine induced brain pathology

2007 ◽  
Vol 165 (2) ◽  
pp. 230-243 ◽  
Author(s):  
I. Klejbor ◽  
E.K. Stachowiak ◽  
D.J. Bharali ◽  
I. Roy ◽  
I. Spodnik ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Viral Gene ◽  
Brain Pathology ◽  
Gene Delivery Vector ◽  
Delivery Vector ◽  
Viral Gene Delivery ◽  
Ormosil Nanoparticles

Novel hyperbranched polyethyleneimine conjugate as an efficient non-viral gene delivery vector

2013 ◽  
Vol 21 (10) ◽  
pp. 1097-1104 ◽  
Author(s):  
Tae-Hun Kim ◽  
Hye Choi ◽  
Gwang Sig Yu ◽  
Jeil Lee ◽  
Joon Sig Choi
Keyword(s):  
Gene Delivery ◽  
Viral Gene ◽  
Gene Delivery Vector ◽  
Delivery Vector ◽  
Viral Gene Delivery

Hyperbranched PEGmethacrylate linear pDMAEMA block copolymer as an efficient non-viral gene delivery vector

2012 ◽  
Vol 434 (1-2) ◽  
pp. 99-105 ◽  
Author(s):  
Asha Mathew ◽  
Hongliang Cao ◽  
Estelle Collin ◽  
Wenxin Wang ◽  
Abhay Pandit
Keyword(s):  
Block Copolymer ◽  
Gene Delivery ◽  
Viral Gene ◽  
Gene Delivery Vector ◽  
Delivery Vector ◽  
Viral Gene Delivery

Towards effective non-viral gene delivery vector

2015 ◽  
Vol 31 (1-2) ◽  
pp. 82-107 ◽  
Author(s):  
Michaela Šimčíková ◽  
Kristala L. J. Prather ◽  
Duarte M. F. Prazeres ◽  
Gabriel A. Monteiro
Keyword(s):  
Gene Delivery ◽  
Viral Gene ◽  
Gene Delivery Vector ◽  
Delivery Vector ◽  
Viral Gene Delivery

An optimized amphiphilic cationic peptide as an efficient non-viral gene delivery vector

2000 ◽  
Vol 2 (6) ◽  
pp. 455-464 ◽  
Author(s):  
Jes�s Fominaya ◽  
Mar�a Gasset ◽  
Rosana Garc�a ◽  
Fernando Roncal ◽  
Juan Pablo Albar ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Viral Gene ◽  
Cationic Peptide ◽  
Gene Delivery Vector ◽  
Delivery Vector ◽  
Viral Gene Delivery

scholarly journals Cardiomyocyte uptake mechanism of a hydroxyapatite nanoparticle mediated gene delivery system

2020 ◽  
Vol 11 ◽  
pp. 1685-1692
Author(s):  
Hiroaki Komuro ◽  
Masahiro Yamazoe ◽  
Kosuke Nozaki ◽  
Akiko Nagai ◽  
Tetsuo Sasano
Keyword(s):  
Gene Delivery ◽  
Transfection Efficiency ◽  
Cell Uptake ◽  
Viral Gene ◽  
Target Cells ◽  
Gene Delivery System ◽  
Uptake Mechanism ◽  
Delivery Vector ◽  
Low Cytotoxicity ◽  
Viral Gene Delivery

Gene therapy has been explored as a future alternative for treating heart disease. Among several gene delivery systems aimed at penetrating specific target cells, we focused on safe and non-viral gene delivery materials with a high transfection efficiency. Although various techniques have been developed, the mechanisms underlying the cellular uptake of gene delivery materials have not yet been sufficiently studied in cardiomyocytes. The aim of this study was to determine how hydroxyapatite (HAp) nanoparticles contribute to the delivery of plasmid DNA (pDNA) into cardiomyocytes. We fabricated HAp nanoparticles using the water-in-oil (W/O) emulsion method and used these nanoparticles as the delivery vector for transfecting cardiomyocyte-derived HL-1 cells. HAp exhibited particles on the nanoscale and with a low cytotoxicity in HL-1 cells. The transfection assay performed with several endocytosis inhibitors suggested that the HAp/pDNA complexes were internalized by HL-1 cells through macropinocytosis. Furthermore, this HL-1 cell uptake was generated in response to HAp stimulation. Thus, HAp is a positive regulator of macropinocytosis in HL-1 cells and a good system for gene delivery in cardiomyocytes.

scholarly journals Construction of a tumor cell-targeting non-viral gene delivery vector with polyethylenimine modified with RGD sequence-containing peptide

2013 ◽  
Vol 7 (2) ◽  
pp. 487-492 ◽  
Author(s):  
HAI-BO XING ◽  
HONG-MING PAN ◽  
YONG FANG ◽  
XIAO-YUN ZHOU ◽  
QIN PAN ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Tumor Cell ◽  
Viral Gene ◽  
Cell Targeting ◽  
Gene Delivery Vector ◽  
Rgd Sequence ◽  
Delivery Vector ◽  
Viral Gene Delivery

Synthesis and characterization of Poly(L-lysine-co-L-proline) as a non-viral gene delivery vector

2006 ◽  
Vol 14 (2) ◽  
pp. 129-131 ◽  
Author(s):  
Soo-Jeong Lee ◽  
Cheol-Hee Ahn ◽  
Jeong Hoon Ko ◽  
Su Young Chae ◽  
Minhyung Lee
Keyword(s):  
Gene Delivery ◽  
Synthesis And Characterization ◽  
Viral Gene ◽  
Gene Delivery Vector ◽  
Delivery Vector ◽  
Viral Gene Delivery

The construction of a novel kind of non-viral gene delivery vector based on protein as core backbone

Vox Sanguinis ◽  
2008 ◽  
Vol 94 (3) ◽  
pp. 234-241
Author(s):  
D. Li ◽  
Y. Kong ◽  
H. Yu ◽  
A. Lehtinen ◽  
H. Huang ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Viral Gene ◽  
Gene Delivery Vector ◽  
Delivery Vector ◽  
Viral Gene Delivery
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