The population genetics of potential Rift Valley fever mosquito vectors in the United States

2016 ◽  
Author(s):  
Lee W. Cohnstaedt
Keyword(s):  
United States ◽  
Population Genetics ◽  
Rift Valley ◽  
Rift Valley Fever ◽  
The United States ◽  
Mosquito Vectors ◽  
Valley Fever

scholarly journals Economic Assessment of Zoonotic Diseases: An Illustrative Study of Rift Valley Fever in the United States

2014 ◽  
Vol 63 (2) ◽  
pp. 203-214 ◽  
Author(s):  
D. L. Pendell ◽  
J. L. Lusk ◽  
T. L. Marsh ◽  
K. H. Coble ◽  
S. C. Szmania
Keyword(s):  
United States ◽  
Rift Valley ◽  
Rift Valley Fever ◽  
Economic Assessment ◽  
The United States ◽  
Zoonotic Diseases ◽  
Valley Fever

scholarly journals Predicting the Mosquito Species and Vertebrate Species Involved in the Theoretical Transmission of Rift Valley Fever Virus in the United States

2014 ◽  
Vol 8 (9) ◽  
pp. e3163 ◽  
Author(s):  
Andrew J. Golnar ◽  
Michael J. Turell ◽  
A. Desiree LaBeaud ◽  
Rebekah C. Kading ◽  
Gabriel L. Hamer
Keyword(s):  
United States ◽  
Rift Valley ◽  
Rift Valley Fever ◽  
Rift Valley Fever Virus ◽  
Mosquito Species ◽  
The United States ◽  
Fever Virus ◽  
Vertebrate Species ◽  
Valley Fever

scholarly journals Rift Valley Fever Virus MP-12 Vaccine Is Fully Attenuated by a Combination of Partial Attenuations in the S, M, and L Segments

2015 ◽  
Vol 89 (14) ◽  
pp. 7262-7276 ◽  
Author(s):  
Tetsuro Ikegami ◽  
Terence E. Hill ◽  
Jennifer K. Smith ◽  
Lihong Zhang ◽  
Terry L. Juelich ◽  
...  
Keyword(s):  
United States ◽  
Rift Valley ◽  
Rift Valley Fever ◽  
Rift Valley Fever Virus ◽  
The United States ◽  
Fever Virus ◽  
Pathogenic Strain ◽  
Wild Type ◽  
Valley Fever ◽  
Content Type

ABSTRACTRift Valley fever (RVF) is a mosquito-borne zoonotic disease endemic to Africa and characterized by a high rate of abortion in ruminants and hemorrhagic fever, encephalitis, or blindness in humans. RVF is caused by Rift Valley fever virus (RVFV; familyBunyaviridae, genusPhlebovirus), which has a tripartite negative-stranded RNA genome (consisting of the S, M, and L segments). Further spread of RVF into countries where the disease is not endemic may affect the economy and public health, and vaccination is an effective approach to prevent the spread of RVFV. A live-attenuated MP-12 vaccine is one of the best-characterized RVF vaccines for safety and efficacy and is currently conditionally licensed for use for veterinary purposes in the United States. Meanwhile, as of 2015, no other RVF vaccine has been conditionally or fully licensed for use in the United States. The MP-12 strain is derived from wild-type pathogenic strain ZH548, and its genome encodes 23 mutations in the three genome segments. However, the mechanism of MP-12 attenuation remains unknown. We characterized the attenuation of wild-type pathogenic strain ZH501 carrying a mutation(s) of the MP-12 S, M, or L segment in a mouse model. Our results indicated that MP-12 is attenuated by the mutations in the S, M, and L segments, while the mutations in the M and L segments confer stronger attenuation than those in the S segment. We identified a combination of 3 amino acid changes, Y259H (Gn), R1182G (Gc), and R1029K (L), that was sufficient to attenuate ZH501. However, strain MP-12 with reversion mutations at those 3 sites was still highly attenuated. Our results indicate that MP-12 attenuation is supported by a combination of multiple partial attenuation mutations and a single reversion mutation is less likely to cause a reversion to virulence of the MP-12 vaccine.IMPORTANCERift Valley fever (RVF) is a mosquito-transmitted viral disease that is endemic to Africa and that has the potential to spread into other countries. Vaccination is considered an effective way to prevent the disease, and the only available veterinary RVF vaccine in the United States is a live-attenuated MP-12 vaccine, which is conditionally licensed. Strain MP-12 is different from its parental pathogenic RVFV strain, strain ZH548, because of the presence of 23 mutations. This study determined the role of individual mutations in the attenuation of the MP-12 strain. We found that full attenuation of MP-12 occurs by a combination of multiple mutations. Our findings indicate that a single reversion mutation will less likely cause a major reversion to virulence of the MP-12 vaccine.

scholarly journals Population Genetics of Two Key Mosquito Vectors of Rift Valley Fever Virus Reveals New Insights into the Changing Disease Outbreak Patterns in Kenya

2014 ◽  
Vol 8 (12) ◽  
pp. e3364 ◽  
Author(s):  
David P. Tchouassi ◽  
Armanda D. S. Bastos ◽  
Catherine L. Sole ◽  
Mawlouth Diallo ◽  
Joel Lutomiah ◽  
...  
Keyword(s):  
Population Genetics ◽  
Rift Valley ◽  
Rift Valley Fever ◽  
Rift Valley Fever Virus ◽  
Disease Outbreak ◽  
Fever Virus ◽  
Mosquito Vectors ◽  
Valley Fever
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