Cytoskeletal Focal Adhesion Proteins Fascin-1 and Paxillin Are Predictors of Malignant Progression and Poor Prognosis in Human Breast Cancer

2015 ◽  
Vol 34 (3) ◽  
pp. 201-212 ◽  
Author(s):  
Ola M. Omran ◽  
Muneera Al Sheeha
Keyword(s):  
Breast Cancer ◽  
Focal Adhesion ◽  
Human Breast Cancer ◽  
Poor Prognosis ◽  
Malignant Progression ◽  
Human Breast ◽  
Adhesion Proteins ◽  
Focal Adhesion Proteins

scholarly journals Expression of programmed death ligand 1 (PD-L1) is associated with poor prognosis in human breast cancer

2014 ◽  
Vol 146 (1) ◽  
pp. 15-24 ◽  
Author(s):  
S. Muenst ◽  
A. R. Schaerli ◽  
F. Gao ◽  
S. Däster ◽  
E. Trella ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Human Breast Cancer ◽  
Poor Prognosis ◽  
Human Breast ◽  
Programmed Death Ligand 1 ◽  
Programmed Death

scholarly journals SRC-1 and Twist1 Expression Positively Correlates with a Poor Prognosis in Human Breast Cancer

2014 ◽  
Vol 10 (4) ◽  
pp. 396-403 ◽  
Author(s):  
Yan Xu ◽  
Baoquan Hu ◽  
Li Qin ◽  
Lianhua Zhao ◽  
Qiang Wang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Human Breast Cancer ◽  
Poor Prognosis ◽  
Human Breast ◽  
Twist1 Expression

Connexin26 expression is associated with lymphatic vessel invasion and poor prognosis in human breast cancer

2007 ◽  
Vol 106 (1) ◽  
pp. 11-17 ◽  
Author(s):  
Yasuto Naoi ◽  
Yasuo Miyoshi ◽  
Tetsuya Taguchi ◽  
Seung Jin Kim ◽  
Takashi Arai ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Human Breast Cancer ◽  
Poor Prognosis ◽  
Lymphatic Vessel ◽  
Lymphatic Vessel Invasion ◽  
Human Breast ◽  
Vessel Invasion

scholarly journals An aberrant spliced transcript of focal adhesion kinase is exclusively expressed in human breast cancer

2014 ◽  
Vol 12 (1) ◽  
pp. 136 ◽  
Author(s):  
Ling Yao ◽  
Kai Li ◽  
Wenting Peng ◽  
Qiang Lin ◽  
Shan Li ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Focal Adhesion Kinase ◽  
Focal Adhesion ◽  
Human Breast Cancer ◽  
Human Breast

scholarly journals The expression of programmed death ligand 1 (PD-L1) is associated with poor prognosis in human breast cancer

2015 ◽  
Vol 41 (1) ◽  
pp. S2
Author(s):  
A. Posabella ◽  
A. Schaerli ◽  
S. Muenst ◽  
F. Gao ◽  
S. Daster ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Human Breast Cancer ◽  
Poor Prognosis ◽  
Human Breast ◽  
Programmed Death Ligand 1 ◽  
Programmed Death

Focal adhesion kinase inhibitory peptides induce apoptosis in human breast cancer cells

2004 ◽  
Vol 11 (S2) ◽  
pp. S68-S69 ◽  
Author(s):  
C. A. Garces ◽  
J. Chang ◽  
R. I. Wilson ◽  
E. V. Kurenova ◽  
V. M. Golubovskaya ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Focal Adhesion Kinase ◽  
Cancer Cells ◽  
Focal Adhesion ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Human Breast Cancer Cells ◽  
Human Breast ◽  
Inhibitory Peptides

scholarly journals Overexpression of SOX2 is associated with poor prognosis in human breast cancer

2021 ◽  
Vol 2 (3) ◽  
Author(s):  
Raquel C Rodrigues ◽  
◽  
Camila P Almeida ◽  
Milena C M Oliveira ◽  
Enio Ferreira ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Invasive Ductal Carcinoma ◽  
Human Breast Cancer ◽  
Poor Prognosis ◽  
Ductal Carcinoma ◽  
Lymph Node Status ◽  
Human Breast ◽  
Sox2 Expression ◽  
Potential Biomarker ◽  
Her 2

SOX2 is a transcription factor that activates or suppresses genes involved in cellular differentiation, proliferation, and apoptosis. The deregulation of gene expression programs can lead to cancer initiation, promotion, and progression. The present study investigated SOX2 immunolocalization and expression in Invasive Ductal Carcinoma (IDC), and its correlation with clinical-pathological characteristics of the tumor. Immunohistochemical expression of SOX2 was evaluated in 19 cases of IDC and correlated with clinical-pathological tumor features. To investigate the correlation of SOX2 expression in IDC with other characteristics of human breast cancer, the same samples were also stained with immunohistochemical prognostic panels (estrogen and progesterone receptors, and HER-2). SOX2 overexpression was observed in 44% of the cases. Higher SOX2 expression was correlated with the worst lymph node status (p<0.001) and with positive HER-2 immunostaining (p<0,001). The present study demonstrated the association of SOX2 and tumors with worse TNM staging, as well as its overexpression in positive HER-2 tumors. In conclusion, SOX2 was identified as a potential biomarker for poor prognosis of human breast cancer. Further studies with higher patient numbers are necessary to investigate and help clarify the mechanisms underlying this association. Keywords: SOX2; HER-2; Breast cancer; IHC; Invasive ductal carcinoma; Prognosis.

scholarly journals A Novel NHERF1 Mutation in Human Breast Cancer and Effects on Malignant Progression

2017 ◽  
Vol 37 (1) ◽  
pp. 67-74 ◽  
Author(s):  
XIAOMEI YANG ◽  
GUIFANG DU ◽  
ZHEN YU ◽  
YANG SI ◽  
TRACEY A MARTIN ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Human Breast Cancer ◽  
Malignant Progression ◽  
Human Breast

Over-expression of both VEGF-C and Twist predicts poor prognosis in human breast cancer

2019 ◽  
Vol 21 (9) ◽  
pp. 1250-1259
Author(s):  
Y.-Q. Zhang ◽  
W.-L. Chen ◽  
F. Zhang ◽  
X.-L. Wei ◽  
D. Zeng ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Human Breast Cancer ◽  
Poor Prognosis ◽  
Human Breast ◽  
Over Expression

scholarly journals Low spinophilin expression is associated with poor prognosis and cellular growth in human breast cancer

2015 ◽  
Vol 26 ◽  
pp. iii29
Author(s):  
D. Schwarzenbacher ◽  
V. Stiegelbauer ◽  
A. Deutsch ◽  
A.L. Ress ◽  
A. Aigelsreiter ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Human Breast Cancer ◽  
Poor Prognosis ◽  
Cellular Growth ◽  
Human Breast
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