human breast cancer cells
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2022 ◽  
Vol 2 ◽  
pp. 1
Author(s):  
Mandana Ameli Mojarad ◽  
Melika Ameli Mojarad ◽  
Mahnaz Noourbakhsh

Objectives: Impact of vitamin D (1, 25 dihydroxy vitamin D3) (calcitriol) in the regulation of different genes has been investigated in different cancers including breast cancer (BC). Material and Methods: In the current study, we analyzed the expression levels of the CYP24A1 and SIRT7 genes and their relationship with patients’ clinical data in BC using polymerase chain reaction (PCR). Afterward, we tend to analyze the effect of vitamin D on the expression of these genes in cell lines (MCF7 and MDAMB231) to find the regulatory role of vitamin D in BC. Results: Our results showed that the CYP24A1 and SIRT7 were increased by vitamin D treatment and CYP24A1 levels were related to tumors stages (p = 0.03) and up-regulation of CYP24A1, SIRT7 had the distinguish potential for breast cancer detection based on their receiver operative characteristic (ROC) curve results (0.77, 0.84, respectively). Conclusion: In summary, CYP24A1, SIRT7 may be used as a possible diagnostic biomarker in BC treatment.


2022 ◽  
Vol 145 ◽  
pp. 112464
Author(s):  
Marina Guimarães Carvalho Machado ◽  
Maria Alice de Oliveira ◽  
Elisa Gomes Lanna ◽  
Raoni Pais Siqueira ◽  
Gwenaelle Pound-Lana ◽  
...  

ACS Omega ◽  
2021 ◽  
Author(s):  
Somenath Banerjee ◽  
Sanjay Roy ◽  
Dhanasekaran Dharumadurai ◽  
Balaji Perumalsamy ◽  
Ramasamy Thirumurugan ◽  
...  

2021 ◽  
Vol 2 ◽  
pp. 100007
Author(s):  
Juliana Moreira Mendonça-Gomes ◽  
Thalita Marcolan Valverde ◽  
Thaís Maria da Mata Martins ◽  
Ives Charlie-Silva ◽  
Barbara Nunes Padovani ◽  
...  

2021 ◽  
Vol 522 ◽  
pp. 211-224
Author(s):  
Poonam Yadav ◽  
Priyanshu Sharma ◽  
Sandhya Sundaram ◽  
Ganesh Venkatraman ◽  
Amal Kanti Bera ◽  
...  

2021 ◽  
Vol 14 (43) ◽  
pp. 3199-3209
Author(s):  
Rajesh Kannan Moorthy ◽  
◽  
Chandhru Srinivasan ◽  
Sridharan Jayamohan ◽  
Mahesh Kumar Kannan ◽  
...  

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