THE EFFECT OF 5-HYDROXYTRYPTAMINE AND OF AN AMINE OXIDASE INHIBITOR ON EXPERIMENTAL DECIDUOMATA IN MICE

SUMMARY Investigations were carried out to study the mechanism by which 5-hydroxytryptamine (5-HT) and monoamine oxidase inhibitors interfere with pregnancy, using the experimental decidual reaction in mice. The results suggest that both 5-HT and an amine oxidase inhibitor, HP. 1325 (2,2′-(p-phenylenedioxy)-di-(ethyl hydrazinium (1+) chloride)), interfere with the endocrine activity of the ovary, particularly the corpus luteum, since their toxic effects on deciduomata are reversed by progesterone. In addition, 5-HT also has a direct toxic effect on decidual tissue.

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INTERRELATION BETWEEN PROGESTERONE, 5-HYDROXYTRYPTAMINE AND HP 1325 IN THE DECIDUAL RESPONSE IN OVARIECTOMIZED MICE

Journal of Endocrinology ◽

10.1677/joe.0.0250053 ◽

1962 ◽

Vol 25 (1) ◽

pp. 53-56 ◽

Cited By ~ 3

Author(s):

D. LINDSAY ◽

E. POULSON ◽

J. M. ROBSON

Keyword(s):

Amine Oxidase ◽

Oxidase Inhibitor ◽

Toxic Effects ◽

Simultaneous Administration ◽

Endocrine Activity ◽

Decidual Tissue ◽

Ovariectomized Mice ◽

The Relationship ◽

Different Levels

SUMMARY Experiments were carried out to study quantitatively in ovariectomized mice the relationship between the dosage of progesterone and the formation of decidual tissue, and to determine whether this relationship would be modified by simultaneous administration of either 5-hydroxytryptamine or an amine oxidase inhibitor HP 1325. As neither of these drugs produced any change in the decidual response at two different levels of progesterone, their toxic effects are probably due to interference with the endocrine activity of the ovary.

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Pheniprazine (cavodil)

Drug and Therapeutics Bulletin ◽

10.1136/dtb.2.26.104-a ◽

1964 ◽

Vol 2 (26) ◽

pp. 104.2-104

Keyword(s):

General Practice ◽

Great Britain ◽

Monoamine Oxidase ◽

Monoamine Oxidase Inhibitor ◽

Oxidase Inhibitor ◽

Toxic Effects ◽

Mao Inhibitors ◽

Treatment Of Depression

Pheniprazine (Cavodil - Benger) is a monoamine oxidase inhibitor which was withdrawn by the manufacturers in 1962, because of its serious toxic effects on the liver and on vision.1 The drug is listed in Medindex (1964, 4, p. 95) and MIMS (December 1964, p. 51) as being indicated in the treatment of depression. Medindex states that the drug has been withdrawn, but is available for patients for whom it is essential. The entry in MIMS mentions neither fact, implying that pheniprazine is one of many MAO inhibitors “available for prescription in general practice in Great Britain”. We consider that it is primarily the responsibility of manufacturers to see that facts of this kind are not omitted from any published information about their drugs. We are glad that the manufacturers of Cavodil have now asked MIMS and Medindex not to list the drug in future editions.

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Studies on the behaviour of semicarbazide-sensitive amine oxidase in Sprague-Dawley rats treated with the monoamine oxidase inhibitor tranylcypromine

MAO — The Mother of all Amine Oxidases - Journal of Neural Transmission. Supplement ◽

10.1007/978-3-7091-6499-0_25 ◽

1998 ◽

pp. 259-264 ◽

Cited By ~ 4

Author(s):

D. H. Fitzgerald ◽

K. F. Tipton ◽

G. A. Lyles

Keyword(s):

Monoamine Oxidase ◽

Amine Oxidase ◽

Monoamine Oxidase Inhibitor ◽

Oxidase Inhibitor ◽

Sprague Dawley ◽

Sprague Dawley Rats

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FRI-314-A novel semicarbazide-sensitive amine oxidase inhibitor, TERN-201, reduces NAS and fibrosis in rodent models of non-alcoholic steatohepatitis

Journal of Hepatology ◽

10.1016/s0618-8278(19)31057-6 ◽

2019 ◽

Vol 70 (1) ◽

pp. e534-e535

Author(s):

Kevin Klucher ◽

Yujin Wang ◽

Yingzi Xu ◽

Randall Halcomb ◽

Martijn Fenaux

Keyword(s):

Amine Oxidase ◽

Oxidase Inhibitor ◽

Rodent Models ◽

Alcoholic Steatohepatitis

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Possible antidepressant/mania-inducing effects of methionine: a reappraisal of the effects of methionine in chronic psychosis using modern diagnostic criteria

Psychiatry and Psychobiology ◽

10.1017/s0767399x00001619 ◽

1989 ◽

Vol 4 (3) ◽

pp. 175-181

Author(s):

J.F. Lipinski ◽

R.C. Alexander

Keyword(s):

Monoamine Oxidase ◽

Diagnostic Criteria ◽

Monoamine Oxidase Inhibitor ◽

Manic Episode ◽

Oxidase Inhibitor ◽

Descriptive Data ◽

Antidepressant Effects ◽

Chronic Psychosis

SummaryThe authors have reviewed 13 published studies on methionine administration, usually in combination with a monoamine oxidase inhibitor (MAOI), to chronically psychotic patients, using modern (DSM-III) diagnostic criteria. Four of these studies contained sufficient descriptive data to allow reappraisal of the effects. The results of the review suggest that a proportion of the patients experienced the induction of a manic episode/antidepressant effects rather than the reported worsening of schizophrenia while treated with a methionine-MAOI combination. It is suggested that these observations are consistent with recent findings that S-adenosyl-L-methionine (SAMe) has antidepressant and mania-inducing effects.

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Peaked “T” Waves with Tranylcypromine (Parnate) Overdose

The International Journal of Psychiatry in Medicine ◽

10.2190/qa6e-7q65-5kwb-8pr2 ◽

1982 ◽

Vol 11 (2) ◽

pp. 155-160 ◽

Cited By ~ 5

Author(s):

Timothy E. Quill

Keyword(s):

Monoamine Oxidase ◽

Intracranial Hemorrhage ◽

Case Reports ◽

Monoamine Oxidase Inhibitors ◽

Toxic Effects ◽

Recent Case ◽

Clinical Use ◽

Ecg Changes ◽

T Waves

A case of tranylcypromine (Parnate) overdose is presented in which the main toxic effects were headache, obtundation, hypertension, and diffusely peaked T-waves on ECG. The latter effect, which occurred in the absence of hyperkalemia, has not been previously associated with monoamine oxidase inhibitors (MAOI). Recent case reports of tranylcypromine toxicity are briefly reviewed, confirming the potential for hypertension, hypotension, shock, hyperpyrexia, intracranial hemorrhage, agitation, hyperkinesis, coma and death in association with overdosage, or concommitant ingestion of sympathomimetic substances or other drugs. These ECG changes add to the worrisome list of potential toxicities in an era in which MAOI are finding increased clinical use.

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