Restoring full-thickness skin defects with a dermal regeneration template and dermal-epidermal cell suspension in a patient with junctional epidermolysis bullosa

2020 ◽  
Vol 30 (2) ◽  
pp. 187-188
Author(s):  
Barbara Bellei ◽  
Flavio Andrea Govoni ◽  
Ettore Bertozzi ◽  
Stefania Bucher ◽  
Antonio Bonadies ◽  
...  
Keyword(s):  
Cell Suspension ◽  
Epidermal Cell ◽  
Epidermolysis Bullosa ◽  
Full Thickness ◽  
Junctional Epidermolysis Bullosa ◽  
Skin Defects ◽  
Full Thickness Skin ◽  
Thickness Skin ◽  
Dermal Regeneration Template ◽  
Dermal Regeneration

666 Autologous Skin Cell Therapy After Dermal Matrix with STSG in a 5-year-old African-American Female - How Adjunct Therapies are Refining the Dogmatic Treatment Approach to Burns

2021 ◽  
Vol 42 (Supplement_1) ◽  
pp. S189-S190
Author(s):  
Alexandra Coward
Keyword(s):  
African American ◽  
Cell Suspension ◽  
Healing Time ◽  
African American Female ◽  
Full Thickness ◽  
Dermal Matrix ◽  
Skin Cell ◽  
Thickness Skin ◽  
Dermal Regeneration

Abstract Introduction Split-thickness skin grafting (STSG) is the standard of care for the treatment of full thickness skin injuries. Skin grafts are associated with long-term morbidity including graft loss, adjacent structural injury, anesthetic complications, scarring, and scar contractures. Large surface area burns are additionally challenging due to limited donor site availability. Autologous skin cell suspension (ASCS) is a new adjunct for STSG using device that provides a suspension of non-cultured, autologous skin cells applied overtop of STSG. Dermal matrix templates are placed on wounds after burn excision and induces dermal regeneration in preparation for STSG, allowing for a thinner graft to be harvested and applied. This technique has been shown to require both smaller areas of donor skin as well as thinner skin harvest which improves both healing time and aesthetic outcomes of donor sites, enhancing the time-tested and well accepted technique of STSG. Methods We present the case of a 5-year-old African American female who suffered 18% TBSA deep partial thickness burns and full thickness burns to her abdomen, trunk and left back after her shirt was accidentally lit on fire at home. She was transferred from a local hospital to our burn center for further evaluation. She was evaluated by both the burn surgery and pediatric teams and admitted for wound cares and surgical planning. Results On hospital day five she underwent burn excision and placement of acellular dermal regeneration template. She returned to the operating room on hospital day 22 after daily wound cares for autografting with autologous skin cell suspension application to anterior and posterior torso and left arm, as well as to back and thigh donor sites. Her takedown on hospital day 29 showed excellent graft take. She was ultimately discharged on hospital day 47. She continued to undergo wound care in the outpatient burn clinic and daily physical and occupational therapy. Conclusions This case illustrates the use of dermal matrix and ASCS on a large burn with excellent aesthetic outcomes and improved healing time. This case is unique in highlighting the versatility of this therapy in a darker skinned patient. There are significant challenges with long term morbidity from STSG and the use of both dermal regenerative matrix and ASCS may provide surgeons with new approaches to decreasing depth and size of donor sites, as well as improving the length of hospital stay and overall aesthetic outcomes of donor and graft sites, specifically in darker skinned patients.

Medial Canthal Reconstruction of Skin Defects With Full-Thickness Skin Grafts

2021 ◽  
Vol 47 (8) ◽  
pp. 1135-1137
Author(s):  
Frank W. de Jongh ◽  
Sjaak Pouwels ◽  
Christien Weenen ◽  
Willem A. van den Bosch ◽  
Dion Paridaens
Keyword(s):  
Skin Grafts ◽  
Full Thickness ◽  
Skin Defects ◽  
Full Thickness Skin ◽  
Thickness Skin

scholarly journals The Use of Matriderm and Autologous Skin Graft in the Treatment of Full Thickness Skin Defects

2014 ◽  
Vol 41 (4) ◽  
pp. 330 ◽  
Author(s):  
Jang Hwan Min ◽  
In Sik Yun ◽  
Dae Hyun Lew ◽  
Tai Suk Roh ◽  
Won Jai Lee
Keyword(s):  
Skin Graft ◽  
Full Thickness ◽  
Skin Defects ◽  
Full Thickness Skin ◽  
Thickness Skin

Skin Grafting

2019 ◽  
pp. 65-72
Author(s):  
Stephen M. Milner
Keyword(s):  
Skin Grafting ◽  
Skin Grafts ◽  
Full Thickness ◽  
Preoperative Preparation ◽  
Scar Contracture ◽  
Skin Defects ◽  
Full Thickness Skin ◽  
Thickness Skin ◽  
Contracture Release

Skin grafting is an indispensable technique used in a variety of clinical situations, including acute burns, traumatic wounds, scar contracture release, and oncological and congenital deficiencies. The author’s preferred techniques for harvesting and resurfacing various skin defects using split- and full-thickness skin grafts are described in this chapter, together with the assessment of donor and recipient sites, preoperative preparation and postoperative considerations.

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