The ovarian morphofunctional status in premenopausal patients with abnormal uterine bleeding after organ-sparing treatments

2018 ◽  
Vol 18 (4) ◽  
pp. 62
Author(s):  
V. G. Breusenko ◽  
G. N. Golukhov ◽  
Yu. A. Golova ◽  
O. I. Mishieva ◽  
T. A. Plakhova ◽  
...  
Keyword(s):  
Abnormal Uterine Bleeding ◽  
Uterine Bleeding ◽  
Organ Sparing Treatments ◽  
Premenopausal Patients ◽  
Organ Sparing

scholarly journals Primary care endometrial sampling for abnormal uterine bleeding: a pilot study

2017 ◽  
Vol 43 (4) ◽  
pp. 296-301 ◽  
Author(s):  
Jon M Dickson ◽  
Brigitte Delaney ◽  
Mary E Connor
Keyword(s):  
Primary Care ◽  
Large City ◽  
Abnormal Uterine Bleeding ◽  
Uterine Bleeding ◽  
First Year ◽  
Initial Management ◽  
Endometrial Sampling ◽  
Premenopausal Patients ◽  
General Practices ◽  
The Uk

AimTo design and evaluate a pilot service for primary care endometrial sampling (PCES).DesignRetrospective analysis of data from two service evaluations.SettingGeneral practices and the gynaecology department in a large city in the UK.MethodsThese were two-fold: (1) To design the new service we identified all the endometrial samples taken in the city’s gynaecology department in 2012/2013 and estimated the proportion of these with abnormal uterine bleeding (AUB) that would be suitable for PCES. (2) To evaluate the new PCES service we analysed data from the first year of activity.Results(1) A total of 1894 endometrial samples were taken in hospital in 2012/2013. An estimated 424 (22.4%) of these were from patients with AUB who fitted the criteria for PCES. (2) In the first year of the PCES service 108 samples were taken by general practitioners (GPs). Initial management of these patients was exclusively in primary care in 97.2% (104/108) of cases; most patients were treated with the Mirena intrauterine system (79/109; 73.1%) and there were no cases of hyperplasia or cancer.ConclusionsMost premenopausal patients with AUB could potentially be managed in primary care without referral to hospital if endometrial sampling (ES) was made available to appropriately trained and supported GPs. However, this study was limited by its retrospective, non-interventional design, and more research is required to demonstrate safety and cost-effectiveness.

scholarly journals COMPARATIVE EFFICACY OF HORMONAL DRUGS FOR THE PREPARATION OF THE ENDOMETRIUM FOR ABLATION IN PREMENOPAUSAL PATIENTS

2019 ◽  
Vol 6 (3) ◽  
pp. 151-156
Author(s):  
Sergey P. Sinchikhin ◽  
E. V Kostenko ◽  
L. V Stepanyan
Keyword(s):  
Endometrial Hyperplasia ◽  
Effective Means ◽  
Abnormal Uterine Bleeding ◽  
Endometrial Ablation ◽  
Uterine Bleeding ◽  
Comparative Efficacy ◽  
Gonadotropin Releasing Hormone Agonist ◽  
Results Of Treatment ◽  
Uterine Mucosa ◽  
Premenopausal Patients

The aim of the study is to compare the effectiveness of the use of hormonal drugs before hysteroresectoscopic ablation of the endometrium in premenopausal patients with abnormal uterine bleeding. Were examined 145 women aged from 45 to 54 years with recurrent endometrial hyperplasia, which were divided into three groups depending on the preoperative use of one of the hormonal drugs (gestagen preparation, microdose estrogen-gestagen contraceptive, gonadotropin-releasing hormone agonist - GnRHa). When medication-induced endometrial atrophy was achieved, the patients underwent hysteroresectoscopic endometrial ablation using the coagulation vaporization technique. The results of the study showed the feasibility of preoperative thinning of the uterine mucosa to improve the results of treatment of its benign changes. The most effective means for accelerating the attainment of drug regression of the endometrium were GnRHa, whose effectiveness was 95.7%. The estrogen-gestagen-containing contraceptive and gestagen preparation showed an efficacy of 65.3% and 42.8%, respectively. The results of the study should be considered when choosing the optimal tactics for management of premenopausal patients with abnormal uterine bleeding.

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