New ideas on the therapeutic effect of a combination of vaccines against pneumococcal, Haemophilus influenzae type b infection, and influenza in patients with chronic obstructive pulmonary disease

2015 ◽  
Vol 87 (3) ◽  
pp. 17 ◽  
Author(s):  
M. P. Kostinov ◽  
A. V. Zhestkov ◽  
A. D. Protasov ◽  
O. O. Magarshak ◽  
T. A. Kostinova
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Haemophilus Influenzae ◽  
Pulmonary Disease ◽  
Therapeutic Effect ◽  
Haemophilus Influenzae Type ◽  
Chronic Obstructive ◽  
Haemophilus Influenzae Type B ◽  
Type B ◽  
Obstructive Pulmonary Disease ◽  
New Ideas

DNA methylation in chronic obstructive pulmonary disease

Epigenomics ◽  
2021 ◽  
Author(s):  
XinXin Huo ◽  
SiHui Jin ◽  
YiGe Wang ◽  
Li Ma
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Dna Methylation ◽  
Pulmonary Disease ◽  
Complex Disease ◽  
Genetic Factors ◽  
Dna Methyltransferases ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Important Health ◽  
New Ideas

Chronic obstructive pulmonary disease (COPD), a complex disease with polygenetic tendency, is one of the most important health problems in the world. Recently, in the study of the pathogenesis of the COPD, epigenetic changes caused by environmental factors, such as DNA methylation, started to attract more attention than genetic factors. In this review, we discuss the main features of DNA methylation, such as DNA methyltransferases and the methylation sites that modulate the DNA methylation level, and their roles in COPD progression. Finally, to promote new ideas for the prevention and treatment of COPD, we focus on the potential of DNA methylation as a COPD therapeutic target.

scholarly journals Serial Isolates of Persistent Haemophilus influenzae in Patients with Chronic Obstructive Pulmonary Disease Express Diminishing Quantities of the HMW1 and HMW2 Adhesins

2008 ◽  
Vol 76 (10) ◽  
pp. 4463-4468 ◽  
Author(s):  
Deborah M. Cholon ◽  
David Cutter ◽  
Stephen K. Richardson ◽  
Sanjay Sethi ◽  
Timothy F. Murphy ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Haemophilus Influenzae ◽  
Pulmonary Disease ◽  
Phase Variation ◽  
High Serum ◽  
Chronic Obstructive ◽  
Structural Genes ◽  
Homologous Proteins ◽  
Obstructive Pulmonary Disease ◽  
Selection For

ABSTRACT In patients with chronic obstructive pulmonary disease (COPD), the lower respiratory tract is commonly colonized by bacterial pathogens, including nontypeable Haemophilus influenzae. The H. influenzae HMW1 and HMW2 adhesins are homologous proteins that promote bacterial adherence to respiratory epithelium and are the predominant targets of the host immune response. These adhesins undergo graded phase variation, controlled by the numbers of 7-bp repeats upstream of the HMW1 and HMW2 structural genes (hmw1A and hmw2A, respectively). In this study, we examined the levels of HMW1 and HMW2 expressed by H. influenzae isolates collected serially from patients with COPD. We found that expression of HMW1 and HMW2 in a given strain decreased over time in a majority of patients, reflecting progressive increases in the numbers of 7-bp repeats and associated with high serum titers of HMW1/HMW2-specific antibodies. We speculate that the presence of high titers of antibodies against the HMW1 and HMW2 adhesins and other immune factors in the lower respiratory tracts of patients with COPD may result in gradual selection for bacteria with reduced levels of HMW1 and HMW2.

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