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2022 ◽  
Vol 48 (1) ◽  
pp. 1-36
Author(s):  
Mirko Myllykoski

The QR algorithm is one of the three phases in the process of computing the eigenvalues and the eigenvectors of a dense nonsymmetric matrix. This paper describes a task-based QR algorithm for reducing an upper Hessenberg matrix to real Schur form. The task-based algorithm also supports generalized eigenvalue problems (QZ algorithm) but this paper concentrates on the standard case. The task-based algorithm adopts previous algorithmic improvements, such as tightly-coupled multi-shifts and Aggressive Early Deflation (AED) , and also incorporates several new ideas that significantly improve the performance. This includes, but is not limited to, the elimination of several synchronization points, the dynamic merging of previously separate computational steps, the shortening and the prioritization of the critical path, and experimental GPU support. The task-based implementation is demonstrated to be multiple times faster than multi-threaded LAPACK and ScaLAPACK in both single-node and multi-node configurations on two different machines based on Intel and AMD CPUs. The implementation is built on top of the StarPU runtime system and is part of the open-source StarNEig library.


Author(s):  
عبد الكريم الدبيسي ◽  
يسرى خالد إبراهيم

The digital environment has brought a lot of changes to the lives of societies and affected and changed their cultures, lifestyles, ways of thinking and interaction with the environment. The digital environment, with its rapid developments, has produced new ideas and behaviors on societies in general and Arab society was not far from these currents, after more than fifteen A year since the Internet entered Iraq, which is one of the most important manifestations of democracy, the latest radical changes in human relations. The information acquired by the human being today is one of the Internet and its culture dependent on it, and here began the study questionably head of that: What is the role of social networking sites in promoting young people's awareness of the importance of the popular movement? The research aims through adopting the survey method (Public Opinion Survey) to identify the most important political, economic and social dimensions of youth awareness that the Internet has brought to them by enhancing information and increasing confidence in the importance of change and persistence on the principle and the research sample is from university students and they are the motors of mobility in the Arab countries Study (Iraq )


2022 ◽  
Vol 8 ◽  
Author(s):  
Guangyao Li ◽  
Shuang Wang ◽  
Zhe Fan

Ischemia-reperfusion (I/R) injury is a manifestation of tissue or organ damage that is followed by ischemia and exacerbated by the return of blood flow to a previously damaged tissue or organ. The intestines are one of the most sensitive tissues and organs to I/R injury. Moreover, the adverse consequences of intestinal I/R (II/R) injury are not limited to the intestine itself and can also lead to damage of the distant tissues and organs. The mechanism of II/R is extremely complex and oxidative stress is the key link in the pathogenesis of II/R injury. This study summarizes the roles of oxidative stress and its signaling pathways involved in II/R. The signaling pathways that mitigate II/R injury include the nuclear factor erythroid-related factor 2 (Nrf2)-mediated signaling pathway, Wnt/β-catenin pathway, and phosphatidylinositol kinase 3 (PI3K)/Akt pathway; those that aggravate II/R injury include the Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway, Toll-like receptor (TLR) receptor-mediated signaling pathway, protein kinase CβII (PKCβII)/p66shc pathway, and microRNA (miRNA)/p66shc pathway; the effect of miRNA on related pathways and mitochondrial DNA translocation. The aforementioned pathways provide new ideas for further exploring the occurrence and development of II/R and more effective treatments for II/R injury.


2022 ◽  
Vol 12 ◽  
Author(s):  
Xin Feng ◽  
Yuelin Bi ◽  
Jiaqi Wang ◽  
Tianyi Li ◽  
Gengyuan Yu ◽  
...  

Background: Zhi-Zi-Hou-Po Decoction (ZZHPD), a classic traditional Chinese medicine (TCM) formula, is clinically used to treat insomnia and depression. The analysis strategy based on the concept of co-decoction of TCM is helpful to analyse the effective substances of TCM formula in depth.Aim of the study: This manuscript intends to take ZZHPD as a model sample to explore the phenomenon of co-decoction of complex formula in the combination of liquid chromatography-mass spectrometry (LC-MS) technology, data analysis, and molecular docking.Materials and methods: In the current research, an innovative LC-MS method has been established to study the active ingredients in ZZHPD, and to identify the ingredients absorbed into the blood and brain tissues of mice. And molecular docking was used to study the binding pattern and affinities of known compounds of the brain tissue toward insomnia related proteins.Results: Based on new processing methods and analysis strategies, 106 chemical components were identified in ZZHPD, including 28 blood components and 18 brain components. Then, by comparing the different compounds in the co-decoction and single decoction, it was surprisingly found that 125 new ingredients were produced during the co-decoction, 2 of which were absorbed into the blood and 1 of which was absorbed into brain tissue. Ultimately, molecular docking studies showed that 18 brain components of ZZHPD had favourable binding conformation and affinity with GABA, serotonin and melatonin receptors. The docking results of GABRA1 with naringenin and hesperidin, HCRTR1 with naringenin-7-O-glucoside, poncirenin and genipin 1-gentiobioside, and luteolin with SLC6A4, GLO1, MAOB and MTNR1A may clarify the mechanism of action of ZZHPD in treating insomnia and depression.Conclusion: Our study may provide new ideas for further exploring the effective substances in ZZHPD.


F1000Research ◽  
2022 ◽  
Vol 11 ◽  
pp. 36
Author(s):  
Becky Ioppolo ◽  
Steven Wooding

Background: Academic sabbaticals are seen as an important aspect of academic life and require considerable resources, however, little research has been done into how they are used and whether their effects can be measured. We explored these issues at the University of Cambridge. Methods: A mixed method approach including 24 interviews with academics, eight interviews with administrators; alongside analysis of administrative and publication data between 2010 and 2019. Results: Academics underline the importance of sabbaticals in providing uninterrupted time for research that is used to think, explore new ideas, master new techniques, develop new collaborations, draw together previous work, set work in a wider context, and provide personal discretion in research direction. They also highlight sabbaticals’ contributions in allowing the beneficial effects of combining teaching and research, while mitigating some of the disadvantages. However, it is difficult to detect the effect of sabbaticals on publications using a time series approach. Conclusions: Sabbaticals provide manifold contributions to academic research at the University of Cambridge; however, detecting and quantifying this contribution, and extending these findings requires wider and more detailed investigation.


2022 ◽  
Vol 3 ◽  
Author(s):  
Saket Pande ◽  
Melissa Haeffner ◽  
Günter Blöschl ◽  
Mohammad Faiz Alam ◽  
Cyndi Castro ◽  
...  

In a recent editorial in the journal Nature Sustainability, the editors raised the concern that journal submissions on water studies appear too similar. The gist of the editorial: “too many publications and not enough ideas.” In this response, we contest this notion, and point to the numerous new ideas that result from taking a broader view of the water science field. Drawing inspiration from a recently hosted conference geared at transcending traditional disciplinary silos and forging new paradigms for water research, we are, in fact, enthusiastic and optimistic about the ways scientists are investigating political, economic, historical, and cultural intersections toward more just and sustainable human-water relations and ways of knowing.


2022 ◽  
Vol 0 (0) ◽  
Author(s):  
Amarpreet Singh Ghura ◽  
Burak Erkut

Abstract This paper explores how firms engage in corporate entrepreneurship through programmes, and what kind of outcomes they achieve in terms of innovations. Insights are drawn from four cases of organisations that engaged in corporate entrepreneurial activities. The paper identifies two dimensions of corporate entrepreneurship programmes as idea themes, indicating whether programmes are designed with specific themes in mind, and idea ownership, indicating whether there is a dedicated team to focus on new ideas, or not. These dimensions are under the direct control of management. Based on these two dimensions, four models of corporate entrepreneurial activities are presented linking each of these models to one of the four cases of product innovations (product line extensions, product improvements, new products, start-up businesses). By drawing on the insights of the effectuation and causation logics, the paper provides a fresh perspective of corporate entrepreneurship programmes in an emerging, non-Western cultural setup and the product innovation context. This is primarily done by introducing a 2 × 2 matrix regarding corporate entrepreneurship idea themes and idea ownership in an emerging context.


2022 ◽  
Vol 12 ◽  
Author(s):  
Min Tang

Based on entrepreneurial psychology, the current situation of foreign students’ use of learning strategies in Chinese learning is explored, the overall situation of learning strategies in this process is analyzed, and the relationship between foreign students’ use of learning strategies and various factors are obtained through the designed questionnaire survey. First, a questionnaire suitable for the research respondents is designed to investigate the current situation of foreign students’ use of learning strategies in Chinese learning; second, 200 questionnaires are distributed, and 195 questionnaires are recovered, with a recovery rate of 97.5%. After the invalid questionnaire is excluded, the effective rate is 95%; furthermore, the reliability of the questionnaire data is analyzed by SPSS25 software, and Cronbach’s α coefficient is 0.869, which proves that the questionnaire has high reliability; finally, the overall situation of foreign students’ use of learning strategies in Chinese learning is analyzed from the aspects of their majors, their levels of Chinese proficiency, Chinese learning time, age and personality. The results show that the frequency of using cognitive strategies in learning Chinese is the highest, with a score of 3.689; There is a positive correlation between the use of learning strategies and the degree of proficiency of Chinese; Among them, the foreign students who have studied for 2–3 years use learning strategies the most frequently, and the students aged 28–32 use learning strategies the most frequently in the Chinese level test 4. This study provides new ideas for foreign students’ Chinese teaching and has a certain reference for foreign students’ Chinese teaching strategies.


Author(s):  
Yuanxi Li ◽  
Rubin Wang ◽  
Tao Zhang

AbstractMajor depressive disorder (MDD) is one of the most serious neuropsychiatric disorders. Exploring the pathogenesis and dynamical coding patterns of MDD can provide new targets for clinical drug treatment and new ideas for the research of other neuropsychiatric and neurodegenerative diseases. We selected the medium spiny neuron (MSN) of nucleus accumbens (NAc) as the research objective. NAc is located in the dopaminergic pathway, regulating rewards, emotions and other behaviors. Abnormalities in these behaviors are considered as the main clinical symptoms of MDD. We simulated the different spike patterns of MSNs in MDD group and control group by dynamical Hodgkin–Huxley model. The simulated results can match the electrophysiological experiments, which occurred due to following reasons: (1) The external stimulus current of MDD group was amplified by the local neural microcircuit; (2) the selective permeability to sodium was abnormally decreased; and (3) the dopamine D2 receptor signaling pathway was abnormal in the MDD group. Furthermore, we proposed a dynamical energy model, and the energy results demonstrated that the energy cost in MDD group was lower, which led to persistent depression in patients with MDD. Simultaneously, the negative-to-total energy ratio of MSN in MDD group was higher than that in control group, and the delay time of the power peak and the potential peak in MDD group was shorter than that in the control group. The results showed that the abnormal firing patterns were the direct cause of abnormal behaviors of MDD and indicated that subthreshold activities of MDD group were more intense.


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