scholarly journals Comutagenic effects of valocordin

2012 ◽  
Vol 10 (3) ◽  
pp. 53-58
Author(s):  
Andrey D Durnev ◽  
Natalia O Daugel-Dauge ◽  
Alii K Zhanataev ◽  
Anastasia S Lapitskaya ◽  
Sergey B Seredenin
Keyword(s):  
Bone Marrow ◽  
Chromosome Aberration ◽  
Mode Of Action ◽  
Bone Marrow Cells ◽  
Combined Administration ◽  
Chromosome Aberration Test ◽  
Marrow Cells

The chromosome aberration test in bone marrow cells of mice was used to study the influence of valocordin on spontaneous and induced clastogenesis. Valocordin showed no inherent clastogenic activity. In experiments with pretreatment and with single or repeated combined administration , valocordin in doses of 0.03, 0.3 and 3 ml/kg significantly (47–133 %) enhanced the clastogenic activity of cyclophosphamide. There was no effect of valocordin on the cytogenetic activity of dioxidine, a mutagen with a pro-oxidative mode of action. Possible mechanisms of comutagenic activity of valocordin are discussed.

Evaluation of genotoxicity of pan masala employing chromosomal aberration and micronucleus assay in bone marrow cells of the mice

2009 ◽  
Vol 25 (7) ◽  
pp. 467-471 ◽  
Author(s):  
BN Mojidra ◽  
K. Archana ◽  
AK Gautam ◽  
Y. Verma ◽  
BC Lakkad ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Chromosome Aberration ◽  
Chromosomal Aberration ◽  
Bone Marrow Cells ◽  
Micronucleus Assay ◽  
Control Group ◽  
Genotoxic Potential ◽  
Polychromatic Erythrocytes ◽  
Significant Difference ◽  
Marrow Cells

Pan masala is commonly consumed in south-east Asian and other oriental countries as an alternate of tobacco chewing and smoking. Genotoxic potential of pan masala (pan masala plain and pan masala with tobacco known as gutkha) was evaluated employing chromosome aberration (CA) and micronucleus (MN) assay in vivo. Animals were exposed to three different doses (0.5%, 1.5% and 3%) of pan masala plain (PMP) and gutkha (PMT) through feed for a period of 6 months and micronucleus and chromosomal aberrations were studied in the bone marrow cells. Induction of mean micronuclei in polychromatic erythrocytes (MNPCE) and normochromatic erythrocyte (MNNCE) was higher in both types of pan masala treated groups with respect to control group. Both pan masala plain and gutkha treatment significantly induced the frequency of MNPCE and MNNCE in the bone marrow cells, indicating the genotoxic potential. Furthermore, slight decline in the ratio of polychromatic erythrocytes to normochromatic erythrocytes was also noticed, suggesting the cytotoxic potential even though the ratio was statistically non significant. A dose-dependent, significant increase in chromosome aberration was observed in both types of pan masala treated mice with respect to control. However, no significant difference in micronucleus and chromosomal aberration induction was noticed between two types of pan masala exposed (PMP and PMT) groups. Results suggest that both types of pan masala, i.e. plain and gutkha, have genotoxic potential.

Genotoxicity Evaluation of Dimethoate to Experimental Mice by Micronucleus, Chromosome Aberration Tests, and Comet Assay

2011 ◽  
Vol 31 (1) ◽  
pp. 78-85 ◽  
Author(s):  
Imen Ayed-Boussema ◽  
Karima Rjiba ◽  
Nourhène Mnasri ◽  
Amal Moussa ◽  
Hassen Bacha
Keyword(s):  
Bone Marrow ◽  
Comet Assay ◽  
Chromosome Aberration ◽  
Bone Marrow Cells ◽  
Mouse Bone Marrow ◽  
Dependent Manner ◽  
Organophosphate Insecticide ◽  
Delayed Effect ◽  
Chromosome Aberration Assay ◽  
Marrow Cells

Dimethoate (DM) is an organophosphate insecticide with numerous uses on field and agricultural crops and ornamentals. Data concerning DM-acute genotoxicity are controversial and knowledge on its delayed effect is limited. For this reason, we aimed to further explore DM genotoxicity resulting from subchronic intoxication of experimental mice. Thus, DM was administered to mice at doses ranging from 1 to 30 mg/kg body weight for a period of 30 consecutive days. There was a significant increase ( P < .05) in the frequency of micronucleated bone marrow cells following DM administration. Furthermore, the chromosome aberration assay revealed a significant increase in the percentage of chromosome abnormalities in a dose-dependent manner. Dimethoate was also found to induce significant DNA damage in mouse bone marrow cells as assessed by the comet assay. Altogether, our results showed that, after a subchronic exposure, DM was a genotoxic compound in experimental mice.

scholarly journals Resveratrol Reduces Radiation-Induced Chromosome Aberration Frequencies in Mouse Bone Marrow Cells

2008 ◽  
Vol 169 (6) ◽  
pp. 633-638 ◽  
Author(s):  
Ronald E. Carsten ◽  
Annette M. Bachand ◽  
Susan M. Bailey ◽  
Robert L. Ullrich
Keyword(s):  
Bone Marrow ◽  
Chromosome Aberration ◽  
Bone Marrow Cells ◽  
Mouse Bone Marrow ◽  
Radiation Induced ◽  
Mouse Bone Marrow Cells ◽  
Marrow Cells

CABG and intramyocardial delivery of CD133+ bone marrow cells: 3-years follow-up on safety and efficacy

2006 ◽  
Vol 54 (S 1) ◽  
Author(s):  
C Stamm ◽  
YH Choi ◽  
A Liebold ◽  
HD Kleine ◽  
S Dunkelmann ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Cells ◽  
Safety And Efficacy ◽  
Intramyocardial Delivery ◽  
Marrow Cells
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