Development of a DNA vaccine encoding the receptor-binding domain of Clostridium difficile toxin A and toxin B, and the role of immune suppression in increased susceptibility to Clostridium difficile infection

Clostridium Difficile Toxin A ◽

Increased Susceptibility

A DNA vaccine targeting the receptor-binding domain of Clostridium difficile toxin A

Vaccine ◽

10.1016/j.vaccine.2009.03.058 ◽

2009 ◽

Vol 27 (27) ◽

pp. 3598-3604 ◽

Cited By ~ 55

Author(s):

David F. Gardiner ◽

Talia Rosenberg ◽

Jerry Zaharatos ◽

David Franco ◽

David D. Ho

Keyword(s):

Clostridium Difficile ◽

Dna Vaccine ◽

Receptor Binding ◽

Binding Domain ◽

Receptor Binding Domain ◽

Toxin A ◽

The complete receptor-binding domain of Clostridium difficile toxin A is required for endocytosis

Biochemical and Biophysical Research Communications ◽

10.1016/s0006-291x(02)02919-4 ◽

2003 ◽

Vol 300 (3) ◽

pp. 706-711 ◽

Cited By ~ 46

Author(s):

Cornelia Frisch ◽

Ralf Gerhard ◽

Klaus Aktories ◽

Fred Hofmann ◽

Ingo Just

Keyword(s):

Clostridium Difficile ◽

Receptor Binding ◽

Binding Domain ◽

Receptor Binding Domain ◽

Toxin A ◽

Role of tumor necrosis factor and nitric oxide in the cytotoxic effects of Clostridium difficile toxin A and toxin B on macrophages

Toxicon ◽

10.1016/s0041-0101(96)00172-9 ◽

1997 ◽

Vol 35 (5) ◽

pp. 743-752 ◽

Cited By ~ 20

Author(s):

A.A. Melo Filho ◽

M.H.L.P. Souza ◽

D.M. Lyerly ◽

F.Q. Cunha ◽

A.A.M. Lima ◽

...

Keyword(s):

Nitric Oxide ◽

Tumor Necrosis Factor ◽

Clostridium Difficile ◽

Tumor Necrosis ◽

Cytotoxic Effects ◽

Toxin B ◽

Clostridium Difficile Toxin A ◽

Necrosis Factor

Immunoglobulin and non-immunoglobulin components of human milk inhibit Clostridium difficile toxin A-receptor binding

Journal of Medical Microbiology ◽

10.1099/00222615-42-1-10 ◽

1995 ◽

Vol 42 (1) ◽

pp. 10-19 ◽

Cited By ~ 36

Author(s):

R. D. Rolfe ◽

W. Song

Keyword(s):

Clostridium Difficile ◽

Human Milk ◽

Receptor Binding ◽

Toxin A ◽

Role of retinol in protecting epithelial cell damage induced by Clostridium difficile toxin A

Toxicon ◽

10.1016/j.toxicon.2007.07.010 ◽

2007 ◽

Vol 50 (8) ◽

pp. 1027-1040 ◽

Cited By ~ 19

Author(s):

Andressa A.F.L. Maciel ◽

Reinaldo B. Oriá ◽

Manuel B. Braga-Neto ◽

Andréa B. Braga ◽

Eunice B. Carvalho ◽

...

Keyword(s):

Epithelial Cell ◽

Clostridium Difficile ◽

Cell Damage ◽

Toxin A ◽

Effects of Clostridium difficile toxin A and toxin B on phospholipase D activation in human promyelocytic leukemic HL60 cells.

Infection and Immunity ◽

10.1128/iai.64.11.4433-4437.1996 ◽

1996 ◽

Vol 64 (11) ◽

pp. 4433-4437 ◽

Cited By ~ 16

Author(s):

K Ohguchi ◽

Y Banno ◽

S Nakashima ◽

N Kato ◽

K Watanabe ◽

...

Keyword(s):

Clostridium Difficile ◽

Phospholipase D ◽

Toxin A ◽

Toxin B ◽

Hl60 Cells ◽

Role of p38alpha/beta MAP Kinase in Cell Susceptibility to Clostridium sordellii Lethal Toxin and Clostridium difficile Toxin B

Toxins ◽

10.3390/toxins9010002 ◽

2016 ◽

Vol 9 (1) ◽

pp. 2 ◽

Cited By ~ 2

Author(s):

Ilona Schelle ◽

Janina Bruening ◽

Mareike Buetepage ◽

Harald Genth

Keyword(s):

Clostridium Difficile ◽

Map Kinase ◽

Lethal Toxin ◽

Toxin B ◽

Clostridium Sordellii ◽

Clostridium Difficile Toxin B

Comparison of Two Enzyme Immunoassay for Detection of Clostridium difficile Toxin A and Toxin B

Annals of Laboratory Medicine ◽

10.3343/kjlm.2009.29.2.122 ◽

2009 ◽

Vol 29 (2) ◽

pp. 122-126 ◽

Cited By ~ 5

Author(s):

Bo-Moon Shin ◽

Soo-Jin Yoo ◽

Hye Jun Oh

Keyword(s):

Clostridium Difficile ◽

Enzyme Immunoassay ◽

Toxin A ◽

Toxin B ◽

Role of the haem oxygenase/carbon monoxide pathway in Clostridium difficile toxin A-induced enteritis in mice

Journal of Medical Microbiology ◽

10.1099/jmm.0.028910-0 ◽

2011 ◽

Vol 60 (8) ◽

pp. 1146-1154 ◽

Cited By ~ 6

Author(s):

C. A. Medeiros ◽

C. A. Warren ◽

R. Freire ◽

C. A. Vieira ◽

B. B. Lima ◽

...

Keyword(s):

Carbon Monoxide ◽

Clostridium Difficile ◽

Toxin A ◽

Clostridium Difficile Toxin A ◽

Haem Oxygenase

140 Protective role of CX3CR1-medicated signal pathway in Clostridium difficile toxin A-induced enteritis

Cytokine ◽

10.1016/j.cyto.2008.07.182 ◽

2008 ◽

Vol 43 (3) ◽

pp. 269

Author(s):

Masanori Inui ◽

Yuko Ishida ◽

Akihiko Kimura ◽

Naofumi Mukaida ◽

Toshikazu Kondo

Keyword(s):

Clostridium Difficile ◽

Protective Role ◽

Signal Pathway ◽

Toxin A ◽