scholarly journals Coexistent molar pregnancy with a normal fetus-a rare presentation of gestational trophoblastic disease

2021 ◽  
Vol 10 (10) ◽  
pp. 3962
Author(s):  
Catarina J. Nascimento ◽  
Mariana Veiga ◽  
Ana Rita Silva ◽  
Joana Cominho
Keyword(s):  
Twin Pregnancy ◽  
Hydatidiform Mole ◽  
Healthy Woman ◽  
Clinical Approach ◽  
Molar Pregnancy ◽  
Complete Hydatidiform Mole ◽  
Consensus Protocol ◽  
Rare Presentation ◽  
Normal Fetus ◽  
Increased Risk

A coexistent molar pregnancy with a normal fetus is rare, with an incidence of 1 in 22.000 to 100.000 pregnancies-only 200 cases reported in the last two decades. The ultrasound is essential for an earlier diagnosis, and the management of these cases is challenging due to the increased risk of obstetrics complications and the possibility of posterior gestational trophoblastic neoplasia. Here we describe a 33-year-old healthy woman with a first-trimester twin pregnancy, presented with a normal fetus and a heterogeneous and vacuolar structure suggestive of complete hydatidiform mole. The pregnancy was interrupted, and a histological diagnosis confirmed complete hydatidiform mole in dichorionic/diamniotic twin pregnancy at 14 weeks. Molar twin pregnancy is a rare condition, and do not exist any consensus protocol to guide the clinical approach, so the decision to continue the pregnancy depends on the couple’s desire and maternal and fetal complications.

scholarly journals Hydatidiform mole coexisting with normal foetus: A rare presentation of a case report from University of Maiduguri Teaching Hospital

2018 ◽  
Vol 1 (1) ◽  
Author(s):  
Abba Kabir ◽  
Abdulkarim A. Kullima ◽  
Adamu I. Adamu ◽  
Anna Peter ◽  
Abba Z. Bukar ◽  
...  
Keyword(s):  
Case Report ◽  
Twin Pregnancy ◽  
Hydatidiform Mole ◽  
Close Monitoring ◽  
Ultrasound Scan ◽  
Complete Hydatidiform Mole ◽  
Intrauterine Pregnancy ◽  
Rare Presentation ◽  
Increased Risk ◽  
Normal Foetus

A twin pregnancy comprising a complete hydatidiform mole coexisting with a foetus is a rare obstetric condition with an incidence of 1 in 22,000 to 1 in 100,000 pregnancies. The management of such case is challenging due to the associated risk of maternal and foetal complications. We report a case of a 25-year-old woman, gravida 2, para 1 with a normal intrauterine pregnancy coexisting with complete hydatidiform mole. An ultrasound scan demonstrated normal foetus and placenta along with coexistent intrauterine echogenic mass with features of hydatidiform mole. The microscopic examination of the abnormal placenta confirmed complete hydatidiform mole. Although twin pregnancy with complete hydatidiform mole and coexistent foetus is associated with increased risk of developing maternal and foetal complications, continuation of pregnancy may be an acceptable option under close monitoring to detect early signs of complications.

scholarly journals Expectant Management of a Twin Pregnancy with Complete Hydatidiform Mole and Coexistent Normal Fetus

2019 ◽  
Vol 2019 ◽  
pp. 1-3
Author(s):  
Colin Johnson ◽  
Caroline Davitt ◽  
Rachel Harrison ◽  
Meredith Cruz
Keyword(s):  
Twin Pregnancy ◽  
Hydatidiform Mole ◽  
Expectant Management ◽  
Fetal Monitoring ◽  
Molar Pregnancy ◽  
Complete Hydatidiform Mole ◽  
Normal Fetus ◽  
Healthy Female ◽  
Negative Woman ◽  
Inpatient Management

Twin pregnancies complicated by complete hydatidiform mole coexisting with a viable fetus are rare and may result in significant complications. We describe the expectant management and our surgical approach in a 27-year-old Rh-negative woman presenting with recurrent episodes of vaginal bleeding and a twin pregnancy consisting of a molar pregnancy coexisting with a normal fetus. Inpatient management was undertaken with close maternal and fetal monitoring until cesarean delivery of a healthy female infant and histopathologically confirmed complete hydatidiform molar pregnancy (karyotype 46XX) at 34 weeks with no evidence of malignancy.

Uterine Rupture in Twin Pregnancy with Normal Fetus and Complete Hydatidiform Mole

2014 ◽  
Vol 77 (2) ◽  
pp. 127-133 ◽  
Author(s):  
María Luisa Sánchez-Ferrer ◽  
Florentina Hernández-Martínez ◽  
Francisco Machado-Linde ◽  
Belén Ferri ◽  
Pablo Carbonel ◽  
...  
Keyword(s):  
Uterine Rupture ◽  
Twin Pregnancy ◽  
Hydatidiform Mole ◽  
Complete Hydatidiform Mole ◽  
Normal Fetus

scholarly journals Partial hydatidiform mole and coexistent live fetus: a case report and review of the literature

Open Medicine ◽  
2019 ◽  
Vol 14 (1) ◽  
pp. 843-846
Author(s):  
Chengying Zeng ◽  
Yanbi Chen ◽  
Lijuan Zhao ◽  
Bo Wan
Keyword(s):  
Case Report ◽  
Pregnant Woman ◽  
Peripheral Blood ◽  
Twin Pregnancy ◽  
Hydatidiform Mole ◽  
Molar Pregnancy ◽  
Review Of The Literature ◽  
Partial Hydatidiform Mole ◽  
Normal Fetus ◽  
Live Fetus

AbstractTwin pregnancy of a hydatidiform mole with a coexistent live fetus is very rare, and complete molar pregnancy is involved in most cases. A partial molar pregnancy almost always ends in miscarriage due to a triploid fetus. Here, we report a case of a 32-year-old Chinese woman with ultrasound diagnosis of a partial molar pregnancy. Amniocentesis suggested mosaicism, but the fetus was morphologically normal. The woman chose to continue the pregnancy after fully understanding the risk. The infant was delivered prematurely, and the presence of a large single placenta with molar changes. The baby’s peripheral blood chromosomes were diploid, and the pregnant woman had no serious complications. The diagnosis, management, and monitoring of this condition will remain challenging because of its rarity. Partial hydatidiform mole combined with pregnancy can result in delivering of a normal fetus and live birth under proper management.

Management of a Dichorionic Twin Pregnancy with a Normal Fetus and an Androgenetic Diploid Complete Hydatidiform Mole

2013 ◽  
Vol 33 (3) ◽  
pp. 194-200 ◽  
Author(s):  
María Luisa Sánchez-Ferrer ◽  
Francisco Machado-Linde ◽  
Alicia Martínez-Espejo Cerezo ◽  
Carolina Peñalver Parres ◽  
Belén Ferri ◽  
...  
Keyword(s):  
Twin Pregnancy ◽  
Hydatidiform Mole ◽  
Complete Hydatidiform Mole ◽  
Normal Fetus

scholarly journals Delivery of Euthyroid Baby following Hyperthyroidism in Twin Gestation with Coexisting Complete Hydatidiform Mole

2019 ◽  
Vol 2019 ◽  
pp. 1-6
Author(s):  
Rishi Raj ◽  
Edilfavia Mae Uy ◽  
Matthew Hager ◽  
Kamyar Asadipooya
Keyword(s):  
Twin Pregnancy ◽  
Molecular Mimicry ◽  
Rare Complication ◽  
Hydatidiform Mole ◽  
Gestational Trophoblastic Disease ◽  
Thyroid Stimulating Hormone ◽  
Dose Titration ◽  
Molar Pregnancy ◽  
Trophoblastic Disease ◽  
Normal Fetus

Context. Gestational trophoblastic disease (GTD) is a rare complication of pregnancy, ranging from molar pregnancy to choriocarcinoma. Twin pregnancies with GTD and coexisting normal fetus are extremely rare with an estimated incidence of 1 case per 22,000–100,000 pregnancies. Molecular mimicry between human chorionic gonadotrophin (hCG) and thyroid-stimulating hormone (TSH) leads to gestational trophoblastic hyperthyroidism (GTH) which is further associated with increased maternal and fetal complications. This is the first reported case in literature describing the delivery of a baby with biochemical euthyroid status following a twin pregnancy with hydatidiform mole (HM) associated with gestational trophoblastic hyperthyroidism (GTH). Case Description. A 24-year-old G4 P3 Caucasian female with twin gestation was admitted to hospital for gestation trophoblastic hyperthyroidism. She was later diagnosed to have twin pregnancy with complete mole and coexisting normal fetus complicated by gestational trophoblastic hyperthyroidism (GTH). Despite the risk associated with the continuation of molar pregnancy, per patient request, pregnancy was continued till viability of the fetus. The patient underwent cesarean section due to worsening preeclampsia and delivered a euthyroid baby at the 24th week of gestation. Conclusions. Twin pregnancy with gestational trophoblastic disease and coexisting normal fetus is associated with high risk of hyperthyroidism, and careful monitoring of the thyroid function test along with dose titration of thionamides is of utmost importance throughout the gestation. If normal thyroid hormone levels are maintained during the pregnancy, euthyroidism could be successfully achieved in the baby.

scholarly journals Cell-Free DNA as an Addition to Ultrasound for Screening of a Complete Hydatidiform Mole and Coexisting Normal Fetus Pregnancy: A Case Report

2020 ◽  
Vol 10 (02) ◽  
pp. e176-e178
Author(s):  
Martina G. Gabra ◽  
Maritza G. Gonzalez ◽  
Holly N. Bullock ◽  
Meghan G. Hill
Keyword(s):  
Hydatidiform Mole ◽  
Uniparental Disomy ◽  
Chorionic Villus ◽  
Chorionic Villus Sampling ◽  
Molar Pregnancy ◽  
Complete Hydatidiform Mole ◽  
Cell Free Dna ◽  
Normal Fetus ◽  
Free Dna ◽  
Pathological Evaluation

Abstract Background Complete hydatidiform mole and coexisting normal fetus pregnancies (CHMCF) are rare and can be life-threatening to the mother. Definitive diagnosis can be made with chorionic villus sampling or amniocentesis. However invasive procedures carry a risk of bleeding. We present the case of a twin molar pregnancy where a cell-free DNA screening test was utilized to evaluate for CHMCF pregnancy. Case A patient presented at 15-week gestational age with suspected CHMCF pregnancy. Ultrasound revealed a normal-appearing pregnancy abutting a multicystic lesion concerning for a complete mole. Cell-free DNA was obtained and was suggestive of complete paternal uniparental disomy. Pathological evaluation of the products of conception confirmed the diagnosis of CHMCF. Conclusion In atypical cases, cell-free DNA may be useful in evaluation of molar pregnancy.

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