scholarly journals Carbamazepine Induced Steven Johnson Syndrome/Toxic Epidermal Necrolysis Overlap Treated Successfully with Oral Cyclosporin

2021 ◽  
Author(s):  
Raqiya Al Rajaibi ◽  
Thuraiya Al Rumhi ◽  
Al Mur Al Abri
Keyword(s):  
Case Report ◽  
Toxic Epidermal Necrolysis ◽  
Gold Standard ◽  
Standard Treatment ◽  
Off Label ◽  
Oral Cyclosporin ◽  
Johnson Syndrome ◽  
Life Threatening ◽  
Steven Johnson Syndrome ◽  
Supportive Management

Steven Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are acute life threatening mucocutaneous drug reactions. Several therapies have been used in the treatment of SJS/TEN but none of them have been established as the gold standard treatment, until now. Studies showed that cyclosporine (CsA) can be used off-label in TEN/SJS and has shown promising therapeutic effectiveness in such diseases. Here we report a 38 year-old woman who presented to Ar Rustaq Hospital, Rustaq, Oman in 2019 with SJS/TEN overlap and was treated successfully with CsA along with supportive management. This case report also includes a literature review on use of CsA in the treatment of SJS/TEN. Keywords: Steven Johnson Syndrome; Toxic epidermal necrolysis; Epidermal necrolysis; cyclosporine; Drug eruption; case report; Oman

scholarly journals Fatal case of toxic epidermal necrolysis induced by ciproflfl oxacin in a child

2021 ◽  
Vol 12 (Supp 1) ◽  
pp. 26-29
Author(s):  
Thomas Schiestel
Keyword(s):  
Case Report ◽  
Toxic Epidermal Necrolysis ◽  
Adverse Reactions ◽  
Pediatric Population ◽  
Fatal Case ◽  
Stevens Johnson Syndrome ◽  
Delayed Treatment ◽  
Drug Eruptions ◽  
Johnson Syndrome ◽  
Life Threatening

Bullous drug eruptions such as Toxic Epidermal Necrolysis (TEN) and Stevens-Johnson syndrome (SJS) are rare but known adverse reactions of fluoroquinolones. Although uncommon, TEN can be life-threatening for the patient, especially in the context of delayed treatment and in fragile patients such as the pediatric population. In the present case, TEN occurred in a 13-year-old girl with no medical history following initiation of ciprofloxacin treatment for an inguinal cyst. We hope that the case report will make interrogate the practices concerning the use of antibiotics, in particular fluoroquinolones in the context of an use not prescribed by the Marketing Authorization of the drug in children.

scholarly journals Stevens-Johnson syndrome induced by phenytoin: a case report

2016 ◽  
Vol 6 (1) ◽  
pp. 208
Author(s):  
Lalkota Prakash Bhanu ◽  
Kumara Swamy M. ◽  
Mohammed Nasiruddin ◽  
Naveen H. D. ◽  
Rajesh Venkataraman
Keyword(s):  
Adverse Reaction ◽  
Case Report ◽  
Toxic Epidermal Necrolysis ◽  
Antiepileptic Drugs ◽  
Stevens Johnson Syndrome ◽  
Drug Reactions ◽  
Cutaneous Adverse Reaction ◽  
Johnson Syndrome ◽  
Life Threatening ◽  
Grade 3

Stevens-Johnson syndrome (SJS) and Toxic epidermal necrolysis (TEN) are rare (one to two per 10,00,00 population per year) but life threatening adverse drug reactions. Antiepileptic drugs-induced Stevens-Johnson syndrome (SJS) is a life-threatening severe cutaneous adverse reaction, amongst anti-epileptics; carbamazepine and phenytoin are the major culprits. We report here a case of SJS due to phenytoin (CTC vs 2 Grade 3).

scholarly journals Stevens-Johnson Syndrome in a Child on Phenytoin, Exacerbated with Cefixime

2019 ◽  
Vol 39 (3) ◽  
pp. 193-196 ◽  
Author(s):  
Yam Bahadur Roka ◽  
Sabrina Shrestha ◽  
Narayani Roka ◽  
Mohan Karki
Keyword(s):  
Toxic Epidermal Necrolysis ◽  
Whole Body ◽  
Stevens Johnson Syndrome ◽  
Intravenous Fluids ◽  
Oral Ulceration ◽  
Topical Antibiotics ◽  
Johnson Syndrome ◽  
Life Threatening ◽  
History Of ◽  
Steven Johnson Syndrome

Steven Johnson syndrome and toxic epidermal necrolysis are rare but potentially life threatening muco-cutaneous disorders. Their incidence ranges from 1.2 to six per million patient-years for Steven Johnson syndrome and 0.4 to 1.2 per million patient-years for toxic epidermal necrolysis. Drugs are the primary cause for these syndromes in majority cases. They might also be due to infections with Mycoplasma Pneumoniae or Herpes Simplex. The mortality ranges from five to 40% in these cases. We report a 10-year old girl who presented with history of multiple skin eruptions involving whole body and oral ulceration for five days. She was a known case of seizure disorder on phenytoin and had been prescribed Cefexime for fever. She was managed with intravenous fluids, corticosteroids, opiates, antacids and topical antibiotics. We want to highlight the possibility of Steven Johnson syndrome following the combination of these two drugs.

scholarly journals Lamotrigine induced Steven Johnson syndrome: A case report in Al Batool teaching hospital in Diyala governorate

2021 ◽  
Vol 20 (2) ◽  
pp. 94-99
Author(s):  
Sura Qais Mahmood Almaroof ◽  
◽  
Issam Tariq Abdul Wahaab
Keyword(s):  
Case Report ◽  
Toxic Epidermal Necrolysis ◽  
Hypersensitive Reaction ◽  
The Body ◽  
Immune Mediated ◽  
Johnson Syndrome ◽  
Mucous Membranes ◽  
The Face ◽  
Systemic Manifestations ◽  
Steven Johnson Syndrome

Background: Steven Johnson syndrome (SJS) is a rare disease that is characterized by acute cutaneous manifestation represented by eruptions of the skin and the mucosal membranes. SJS is an immune-mediated disease, a hypersensitive reaction, characterized by hyperpigmentation of the mucous membranes, rash on the skin and multiple bullae and erosions scattered all over the body especially the face, trunk, and the extremities. Many studies reported that the incidence rate of the SJS was about 1.2 – 6 cases/ million each year and it is more common among males while the toxic epidermal necrolysis (TEN) is more common among females. In addition to the cutaneous manifestations.SJS might show multiple systemic manifestations including the liver, lungs and kidneys. In this case we reported the development of Steven Johnson syndrome in relation to the use of lamotrigine antiepileptic drug.

scholarly journals Cotrimoxazole Induced Steven Johnson Syndrome: A Case Report

2020 ◽  
Vol 58 (229) ◽  
Author(s):  
Ayushma Acharya ◽  
Shreedhar Prasad Acharya ◽  
Tulsi Bhattarai
Keyword(s):  
Target Lesion ◽  
Burning Sensation ◽  
The Body ◽  
Drug Reactions ◽  
Broad Spectrum Antibiotic ◽  
Johnson Syndrome ◽  
Threatening Condition ◽  
Life Threatening ◽  
Steven Johnson Syndrome ◽  
Supportive Management

Steven Johnson syndrome and toxic epidermal necrolysis are severe and rare adverse drug reactions usually caused by drugs like antiepileptics, penicillin and allopurinol and sometimes also due to infections, malignancy or idiopathic in some cases. Here we are reporting a case of a 50 years female who came with complaint of a burning sensation on the upper half of the body with atypical flat target lesion that later coalesced involving her face, chest and bilateral upper limbs. On examination, positive nikolsky sign and tenderness with <10% body surface area involvement was noticed. The diagnosis of cotrimoxazole induced Steven Johnson syndrome was made. Patient was shifted to ICU and given supportive care along with prophylactic teicoplanin, itraconazole and dexamethasone. The mechanism of eruptions in our patient was due to cotrimoxazole. Cotrimoxazole induced Steven Johnson syndrome is rare and the supportive management with broad spectrum antibiotic and the corticosteroid was enough to beat this life-threatening condition.

scholarly journals Toxic epidermal necrolysis in a 5-year-old boy - case report

2016 ◽  
Vol 19 (4) ◽  
pp. 114
Author(s):  
Pavan Puri ◽  
Sana Shaikh ◽  
Adesh Kakade ◽  
Rajiv Desai ◽  
Rahul Rahinj ◽  
...  
Keyword(s):  
Case Report ◽  
Toxic Epidermal Necrolysis ◽  
Varicella Zoster Virus ◽  
Etiological Agent ◽  
Stevens Johnson Syndrome ◽  
Varicella Zoster ◽  
Johnson Syndrome ◽  
Life Threatening

<p>Toxic epidermal necrolysis (TEN) and Stevens-Johnson syndrome (SJS) are considered a spectrum of acute life-threatening mucocutaneous reaction that differ only in severity, often induced by drugs. Varicella-zoster virus has been rarely reported as an etiological agent in TEN. Our case report highlights the association of varicella-zoster virus and TEN in a 5-year-old boy.</p><p><strong>Keywords: </strong>Life-threatening, Toxic epidermal necrolysis (TEN), Varicella-zoster virus.</p>

scholarly journals A CASE REPORT ON AMOXICILLIN INDUCED STEVENS- JOHNSON SYNDROME

2021 ◽  
Vol 12 (7) ◽  
pp. 22-24
Author(s):  
Rispa Darabadi ◽  
Karasani Harini
Keyword(s):  
Case Report ◽  
Mucous Membrane ◽  
Case Reports ◽  
The Body ◽  
Stevens Johnson Syndrome ◽  
Johnson Syndrome ◽  
Oral Consumption ◽  
Life Threatening ◽  
Steven Johnson Syndrome

Steven-Johnson syndrome (SJS) is a rare, serious disorder of the skin and mucous membrane that is usually a reaction to medication. It usually starts with flu-like symptoms, followed by a painful rash that spreads and blisters. Other symptoms include Fever, sore mouth and throat, Fatigue, burning eyes, extensive skin and mucous membrane lesions (i.e., mouth, nose, esophagus, anus, and genitalia), epidermis detachment, and acute skin blisters. In 95% of case reports, drugs were identified to be an important cause for the development of SJS. The below is a case report of A 37-year-old male patient hospitalized with rashes over the body and fever, after oral consumption of Amoxicillin drug for cough and sore throat through OTC prescription. The patient has taken three doses of Amoxicillin and due to lack of awareness on Adverse drug reactions, the patient ignored the rashes that were developed after the first dose. This case study discusses the possibility of serious hypersensitivity reactions with Amoxicillin that rarely occur and can be extremely harmful and life threatening, brief knowledge on Stevens-Johnson syndrome and also some of the preventive measures to control the adverse reactions due to drugs.

Self-medication of Ayurvedic Medicine Associated with Fatal Toxic Epidermal Necrolysis: A Case Report

2020 ◽  
Vol 6 (3) ◽  
pp. 250-255
Author(s):  
Manjeet Singh Jangra ◽  
Manik Chhabra ◽  
Akshaya Srikanth Bhagavathula
Keyword(s):  
Case Report ◽  
Toxic Epidermal Necrolysis ◽  
World Health ◽  
Ayurvedic Medicine ◽  
Self Medication ◽  
Synthetic Drugs ◽  
Johnson Syndrome ◽  
Steven Johnson Syndrome ◽  
Health Organization ◽  
Present Case Study

Introduction: Ayurveda is one of the most renowned traditional systems of medicine and is widely practiced in India. Self-medication of these ayurvedic medicines (AM’s) may elicit more or less similar type of adverse reactions as synthetic drugs. Methods: We present a case report on toxic epidermal necrolysis due to self-medication of ayurvedic medicine. Case Report: The present case is of a patient who used Singhnad Guggulu for 20 days and developed Steven-Johnson Syndrome (SJS) followed by toxic epidermal necrolysis (TEN). The patient was treated with steroids and antihistamines. The patient recovered completely following seven days of treatment and discharged. Results: After ruling out the provisional diagnosis, the patient was diagnosed with druginduced SJS/TEN. The World Health Organization-Uppsala Monitoring Center (WHOUMC) causality assessment scale was used by taking into consideration the temporal relationship and other relevant parameters and adverse drug reaction (ADR) was found to be ‘certain’. Conclusion: To our knowledge, the present case study is the first report of SJS/TEN that was caused by “Singhnad Guggulu” suggesting clinicians to be vigilant about the possibility of SJS/TEN occurrences with AM. Also, consumers should be advised to use these drugs only on the prescription of the institutionally qualified ayurvedic practitioners.

scholarly journals Phenytoin induced Stevens-Johnson syndrome: a case report

2018 ◽  
Vol 7 (3) ◽  
pp. 573
Author(s):  
Shambhavi Kulkarni ◽  
A. N. Dattatri
Keyword(s):  
Case Report ◽  
Toxic Epidermal Necrolysis ◽  
Adverse Drug Reactions ◽  
Stevens Johnson Syndrome ◽  
Drug Reactions ◽  
Johnson Syndrome ◽  
Life Threatening ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Toxic epidermal necrolysis (TEN) and Stevens-Johnson syndrome (SJS) are rare but potentially life threatening cutaneous adverse drug reactions. Drugs commonly implicated are anti-microbials, anti-epileptics and non-steroidal anti-inflammatory drugs (NSAIDs). Amongst anti-epileptics, carbamazepine and phenytoin are the most common offending drugs. We report here a case of SJS due to phenytoin.

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