Infiuence of parameters of artificial pulmonary ventilation and microaspiration of gastric contents on the frequency of development of neonatal pneumonia

Author(s):  
E.Yu. Bryksina ◽  
◽  
A.V. Pochivalov ◽  
V.S. Bryksin ◽  
◽  
...  
2016 ◽  
Vol 71 (2) ◽  
pp. 128-140
Author(s):  
E. Y. Bryksina ◽  
V. S. Bryksin ◽  
A. V. Pochivalov

Today the influence of the digestive tract functional violations followed by microaspiration of gastric contents (MAGC) on the incidence, features and outcomes of bronchopulmonary dysplasia BPD) remains little studied. Focusing on this aspect makes the research actual.Objective: determination of the nature of influence of MAGC on the progress and course of BPD.Methods: 373 newborns exposed to artificial pulmonary ventilation (APV) in the neonatal period were examined. In a tracheobronchial aspirate (TBA) the marker of MAGC – pepsin –was determined. Its activity was measured by extinction value with subsequent analysis of the incidence and nature of the course of bronchopulmonary dysplasia (BPD) in patients against MAGC and without it. During the three years follow-up period outcomes of BPD and features of combined pathology were established.Results: it was revealed that in children suffered from MAGC the incidence of BPD was higher and grew in proportion to the increase of pepsin activity in TBA and the reduction of gestational age. The extinction increase in TBA values was followed by the increase in duration of APV and the subsequent oxygen therapy, and also the severity of BPD clinical course. By the end of 3 years clinical recovery was detected in 55,2% of children suffering from BPD without MAGC whereas in patients with BPD against MAGC this outcome occured only in 0,9% of cases.Conclusion: MAGC is clinically significant for the etiology, pathogenesis and pathomorphism of BPD. The proposed method of early detection of MAGC and algorithm of complex therapy can reduce its severity and improve the forecast accuracy of neonatal adaptation. 


2005 ◽  
Vol 3 (1) ◽  
pp. 0-0
Author(s):  
Kristina Vostrugina ◽  
Daiva Gudavičienė ◽  
Rytis Rimdeika

Kristina Vostrugina, Daiva Gudavičienė, Rytis RimdeikaKauno medicinos universiteto klinikųPlastinės chirurgijos ir nudegimų skyrius,Eivenių g. 2, LT-50009 KaunasEl paštas: [email protected] Tikslas Ištirti 1999–2003 m. Kauno medicinos universiteto klinikų Plastinės chirurgijos ir nudegimų skyriaus ligonių, kuriems patvirtinta bakteriemija, gydymo aspektus. Ligoniai ir metodai Atlikta retrospektyvi 82 nudegusių ligonių, kuriems patvirtinta bakteriemija, ligos istorijų analizė. Vertintas pacientų amžius, nudegimą sukėlę veiksniai, nudegimo plotas, kvėpavimo takų nudegimas. Analizuota, kokiam skaičiui pacientų reikėjo kateterizuoti centrines venas, prireikė dirbtinės plaučių ventiliacijos, enterinio ar parenterinio maitinimo, kokių radosi komplikacijų, kokie mikroorganizmai išaugo žaizdų pasėliuose ir toks jų sutapimas su kraujo pasėlių duomenimis, nagrinėti antibiotikų terapijos aspektai. Rezultatai Pacientų, kuriems patvirtinta bakteriemija, vidutinis amžius buvo 50 metų, standartinis nuokrypis – 16. Vyravo nudegimai liepsna (82%) ir skysčiais (8,5%). Vidutinis nudegusio kūno paviršiaus plotas buvo 29%, standartinis nuokrypis – 19. Centrines venas reikėjo kateterizuoti 78% pacientų. Dirbtinės plaučių ventiliacijos prireikė 13% pacientų. Enterinis maitinimas skirtas 48% pacientų, parenteriniu būdu maitinta 90% ligonių. Pneumonija nustatyta 29% pacientų, kardiovaskulinis nepakankamumas – 15%, dauginis organų funkcijos nepakankamumas – 13%, inkstų funkcijos nepakankamumas – 7% ligonių. Visais atvejais sutapo žaizdos ir kraujo pasėlių duomenys, kai iš kraujo išaugo Pseudomonas aeruginosa, 87% – kai išaugo meticilinui atsparus Staphylococcus aureus ir 74% – kai išaugo meticilinui jautrus S. aureus. Antibiotikais gydyta 80 ligonių, dažniausiai penicilinu, gentamicinu ir vankomicinu. Išvados Bakteriemija dažnai nustatoma didelius plotus nudegusiems ligoniams, kuriems tenka kateterizuoti centrines venas, skirti parenterinį maitinimą. Dažniausiai iš kraujo mėginių išauga tie mikroorganizmai, kurie auga žaizdų pasėliuose. Reikšminiai žodžiai: nudegimai, bakteriemija, antibiotikų terapija Treatment of burned patients with diagnosed bacteremia Kristina Vostrugina, Daiva Gudavičienė, Rytis RimdeikaKaunas University of Medicine Hospital,Department of Plastic Surgery and Burns,Eivenių str. 2, LT-50009 Kaunas, LithuaniaE-mail: [email protected] Objective The aim of the study was to investigate the aspects of treatment of burned patients with confirmed bacteremia treated at Kaunas University of Medicine Hospital Department of Plastic Surgery and Burns during 1999–2003. Patients and methods A retrospective analysis of case histories of 82 burned patients with confirmed bacteremia was performed. The evaluated factors included the patients’ age, factors that caused the burns, the burned area, and burns of the airways. We also analyzed how many patients required catheterization of the central veins, artificial pulmonary ventilation, enteral or parenteral feeding, and complications, as well as what microorganisms grew in wound crops, how many cases corresponded to the blood crop findings, and the aspects of antibiotic therapy. Results Mean age of patients with confirmed bacteremia was 50 years, standard deviation (SD) – 16. Flame burns (82%) and scalds (8.5%) predominated. Mean burned body surface area was 29%, SD – 19. 78% of patients required catheterization of central veins, and 13% – artificial pulmonary ventilation. 48% of patients were fed enterally, and 90% – parenterally. 29% of patients had pneumonia, 15% – cardiovascular insufficiency, 13% – multiple organ failure, and 7% – renal failure. The coincidence of the findings of wound and blood crops was 100% in cases of Pseudomonas aueruginosa growth, 87% – in cases of methicillin-resistant Staphylococcus aureus growth, and 74% – in cases of methicillin-sensitive Staphylococcus aureus growth. 80 patients received antibiotics, mostly penicillin, gentamicin, and vancomycin. Conclusions Bacteremia was very common among extensively burned patients requiring catheterization of the central veins and parenteral feeding. In most cases, microorganisms that grew in wound crops also grew in blood samples. Key words: burns, bacteremia, antibiotic therapy


2017 ◽  
Vol 86 (1) ◽  
pp. 36-41
Author(s):  
V. S. Isachenko ◽  
◽  
D. M. Il’yasov ◽  
A. M. Mel’nik ◽  
V. Yu. Ovchinnikov ◽  
...  

1973 ◽  
Vol 7 (3) ◽  
pp. 166-168
Author(s):  
A. B. Gruzman ◽  
V. M. Yurevich

Sign in / Sign up

Export Citation Format

Share Document