scholarly journals Diagnostic Utility of Fine Needle Aspiration Cytology and Cell Block Technique in Thyroid Lesions

2020 ◽  
Vol 08 (07) ◽  
Author(s):  
Dr. Jasleenkaur S Oberoi ◽  
Keyword(s):  
Fine Needle Aspiration ◽  
Fine Needle Aspiration Cytology ◽  
Needle Aspiration ◽  
Diagnostic Utility ◽  
Cell Block ◽  
Aspiration Cytology ◽  
Fine Needle ◽  
Needle Aspiration Cytology ◽  
Thyroid Lesions

The diagnostic utility of cell block in fine needle aspiration cytology of palpable breast lesions in a Nigerian tertiary health institution

2020 ◽  
Vol 48 (12) ◽  
pp. 1300-1306
Author(s):  
Fred John Nnaemeka Obiajulu ◽  
Adetola Olubunmi Daramola ◽  
Charles Chidozie Anunobi ◽  
Nzechukwu Zimudo Ikeri ◽  
Fatimah Biade Abdulkareem ◽  
...  
Keyword(s):  
Fine Needle Aspiration ◽  
Fine Needle Aspiration Cytology ◽  
Needle Aspiration ◽  
Breast Lesions ◽  
Diagnostic Utility ◽  
Cell Block ◽  
Aspiration Cytology ◽  
Fine Needle ◽  
Palpable Breast ◽  
Needle Aspiration Cytology

scholarly journals Diagnostic Utility of Cell Block Technique as an Adjunct Technique to Cytological Smears in Evaluation of Thyroid Aspirates on Fine Needle Aspiration Cytology

1969 ◽  
Vol 11 (4) ◽  
pp. 217-222
Author(s):  
Amreek Lal ◽  
Siyab Ahmad ◽  
Waseem Khan ◽  
Liaqat Ali ◽  
Mian Anwar Zeb ◽  
...  
Keyword(s):  
Informed Consent ◽  
Fine Needle Aspiration ◽  
Fine Needle Aspiration Cytology ◽  
Needle Aspiration ◽  
Diagnostic Utility ◽  
Cell Block ◽  
Aspiration Cytology ◽  
Fine Needle ◽  
Significant Difference ◽  
Needle Aspiration Cytology

Background: Fine needle aspiration cytology is a standard screening technique for the diagnosis and assessment of thyroidnodules. However, this approach has some drawbacks, such as false negative or positive outcomes and high rates ofunsatisfactory results.Objective: To describe the utility of cell block technique as an adjunct to conventional smear in the cytodiagnosis of thyroidepithelial lesions.Material and Methods: This Descriptive Cross-sectional study was done at the Pathology department of Saidu Group of TeachingHospital Saidu Sharif Swat from 1st November 2017 to 31st April 2018. Fine needle aspirates for both the direct smear and cell blockwere collected simultaneously from 60 patients, through non- probability convenient sampling. All patients having clinicallyenlarged thyroid, solitary or dominant thyroid nodule were included in the study.All patients below 22 years old and patients who didnot give informed consent were excluded. Ethical clearance was obtained from the ethical research committee before carrying outthe study. Written informed consent was taken from all the participating patients.Cellularity, obscuring background material, morphological and architectural preservation as well as cytodiagnosis on direct smearand cell block technique were compared. Data were analyzed using SPSS software version 21. McNemar's chi-square test wasapplied for significant difference. P-value of = 0.05 was considered significant.Results: Male to Female ratio was 1:7.5, (13%: 87%). The age ranged from 22 to 81 years with a mean age of 44.9 and standarddeviation of ±14.5 years. The study showed that the cell block technique has high cellularity, minimal obscuring background, betterarchitectural preservation and poor morphological preservation on cell block in comparison to direct smear. The majority of thecases were benign on both techniques. The unsatisfactory rate was reduced in cell block technique and showed additionalinformation in 13 % cases.Conclusion: The study demonstrated no significant difference in the diagnostic utility of both techniques.Keywords: Cell Block Cytopathology, FNAC, Mair et al criteria

scholarly journals Diagnostic Efficacy of Fine Needle Aspiration Cytology and Cell Block Technique in Thyroid Lesions: A Hospital-based Study

2020 ◽  
Author(s):  
Usha Kiran Raina ◽  
Jyotsna Suri ◽  
Subash Bhardwaj ◽  
Bhavna Sahni
Keyword(s):  
Fine Needle Aspiration ◽  
Predictive Value ◽  
Fine Needle Aspiration Cytology ◽  
Needle Aspiration ◽  
Cell Block ◽  
Aspiration Cytology ◽  
Diagnostic Efficacy ◽  
Fine Needle ◽  
Needle Aspiration Cytology ◽  
Thyroid Lesions

Introduction: Fine Needle Aspiration Cytology (FNAC) and Cell Block are very commonly used initial tests for triaging thyroid lesions and play a pivotal role in deciding subsequent clinical management of thyroid nodules. In most cases, after excision, the diagnosis remains unchanged, but at times discordance does occur when benign lesions are reported on FNAC and cell blocks are found to be malignant on final histopathology and vice-versa. Aim: To assess the diagnostic efficacy of both FNAC and Cell Block technique in the evaluation of thyroid lesions by comparing their respective results with final histopathological diagnosis (after excision) in case of malignancies and clinico- radiological follow-up in benign cases. Materials and Methods: An observational hospital-based study was conducted in the Department of Pathology in a Tertiary Care Teaching Institute from 1st November, 2016 to 31st October, 2017. A total of 100 cases of thyroid masses were subjected to both FNAC and Cell Block and the diagnostic efficacy of both the techniques was assessed using MedCalc Statistical Software. Results: Mean age of the patients was 42.75±15.75 years with a range of 12-75 years. Females constituted 88% of the sample with male to female ratio of 1:7.3. 88% lesions were benign, 8% were malignant and 4% suspicious of malignancy on conventional smears in comparison to cell block which showed 90% benign, 8% malignant and 2% suspicious lesions. The validity of FNAC in terms of sensitivity, specificity, Positive Predictive Value (PPV), Negative Predictive Value (NPV) and accuracy was found to be 100%, 95.65%, 66.67%, 100.00% and 96.00% respectively, whereas for cell blocks these statistics were 100%, 97.83%, 80%, 100% and 98% respectively. Conclusion: Cell block improved the overall diagnostic accuracy of FNAC when used as an adjunct leading to 100% diagnostic yield. The results of this study also establish that FNAC and Cell blocks are sensitive, specific, and accurate as preliminary diagnostic tests for evaluation of patients with thyroid swellings. Moreover, their combined use can reduce the diagnostic errors and to improve the overall reporting efficacy. It is thus advised to perform cell block for each case of FNAC in thyroid lesions.

Cell Block and Its Impact in the Diagnosis of Jaw Lesions over Fine Needle Aspiration Cytology

2021 ◽  
pp. 1-7
Author(s):  
Kaveri Hallikeri ◽  
Biji Babu ◽  
Archana Sudhakaran ◽  
Roshni Monteiro
Keyword(s):  
Fine Needle Aspiration ◽  
Fine Needle Aspiration Cytology ◽  
Dentigerous Cyst ◽  
Needle Aspiration ◽  
Histopathological Diagnosis ◽  
Cell Block ◽  
Aspiration Cytology ◽  
Fine Needle ◽  
Dentigerous Cysts ◽  
Needle Aspiration Cytology

<b><i>Objectives:</i></b> To determine the role and efficacy of fine needle aspiration cytology (FNAC) and cell block in diagnosis of jaw lesions and compare the agreement between FNAC and cell block to predict the diagnosis. <b><i>Method:</i></b> The sample comprised 51 cases, including 12 odontogenic keratocysts (OKCs), 8 ameloblastomas, 22 radicular cysts, 7 dentigerous cysts, and 1 each of intraosseous mucoepidermoid carcinoma (MEC) and adenomatoid odontogenic tumor (AOT). FNAC samples remaining after hematoxylin and eosin (H&amp;E)-stained cytosmear diagnosis were centrifuged at 3,000 rpm for 10 min. The supernatant was discarded and sediment mixed with 2–3 mL alcohol and filtered. To this, 10% formalin was added, filtered, taken for routine processing, and stained with H&amp;E. The result of FNAC smear and cell block was compared with histopathological diagnosis. <b><i>Results:</i></b> On cytological examination of the smears, 7 OKCs and 22 radicular cysts were diagnosed, whereas ameloblastomas, AOT, intraosseous MEC, and dentigerous cysts were not. This gave an agreement of 56.8% with the biopsy reports. Cell block sections stained with H&amp;E of 12 OKCs, 22 radicular cysts, 1 MEC, and 3 cases of ameloblastoma offered a diagnosis in accordance with the biopsies giving an agreement of 74.5%, while dentigerous cyst and AOT failed to do so. In comparison with FNAC, additionally 5 cases of OKC and 1 of MEC could be detected, and in ameloblastoma, out of 8 cases, only 3 yielded a concordant diagnosis through the cell block technique. <b><i>Conclusion:</i></b> In comparison with FNAC, the architectural pattern and the morphology of the cells were better preserved by the cell block technique. This substantiates that cell block could be used as an ancillary technique to aid in definitive diagnosis of head and neck swellings.

Cytopathological Evaluation of Thyroid Lesions Based on Bethesda System in Patients Attending Birat Medical College and Teaching Hospital

2020 ◽  
Vol 22 (4) ◽  
pp. 260-265
Author(s):  
Neeta Kafle ◽  
B Koirala ◽  
SU Kafle ◽  
M Singh ◽  
A Sinha
Keyword(s):  
Teaching Hospital ◽  
Fine Needle Aspiration ◽  
Fine Needle Aspiration Cytology ◽  
Needle Aspiration ◽  
Aspiration Cytology ◽  
Fine Needle ◽  
Medical College ◽  
Bethesda System ◽  
Needle Aspiration Cytology ◽  
Thyroid Lesions

More than 50% of the world’s population has at least a thyroid nodule. Detail clinical examination and radiology may help in diagnosing thyroid lesions but the management depends upon the cytopathological diagnosis. Optimum use of fine needle aspiration cytology (FNAC) and better understanding of cytomorphological characteristic of thyroid lesions by using Bethesda system, triaging of patients who are to be treated medically or surgically is more accurate. The objective of this present study is cytopathological evaluation of thyroid lesions based on Bethesda System in patients attending Birat Medical College and Teaching Hospital. The objective was also to correlate the cytological findings with histopathological findings where ever possible. A total of 104 patients with thyroid lesions underwent fine needle aspiration cytology in a period of a year (September 1, 2019 to August 31, 2020). Cytological features were evaluated and classified according to the Bethesda system. Histopathological features were evaluated and correlated wherever available. Among 104 patients with thyroid lesions 93 were female and 11 were male. Four cases turned out to be non diagnostic, 85 benign, three Atypia of undetermined significance, three Suspicious for follicular neoplasm and eight Suspicious of malignancy and one Malignant according to Bethesda system. Histopathology specimen was received in 31 patients out of whom 20 (64.5%) patients were reported as colloid nodule, two follicular adenoma, one Hurthle cell adenoma, six papillary carcinoma and two follicular carcinoma. Medullary carcinoma and anaplastic carcinoma were not seen in the patients evaluated. Specificity and sensitivity of fine needle aspiration cytology was 94.7% and 88.9% respectively. Thus reporting thyroid lesions FNAC with Bethesda system allow a more specific cytological diagnosis.

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