scholarly journals Prognostic role of DEK in human solid tumors: a meta-analysis

Oncotarget ◽  
2017 ◽  
Vol 8 (58) ◽  
pp. 98985-98992
Author(s):  
Gang Liu ◽  
Disheng Xiong ◽  
Junjie Zeng ◽  
Guoxing Xu ◽  
Rui Xiao ◽  
...  
Keyword(s):  
Solid Tumors ◽  
Meta Analysis ◽  
Prognostic Role ◽  
Human Solid Tumors

scholarly journals Prognostic significance of NEK2 in human solid tumors: a systematic review and meta-analysis

2019 ◽  
Vol 39 (1) ◽  
Author(s):  
Xichen Wang ◽  
Kang Chen ◽  
Haipeng Liu ◽  
Zeping Huang ◽  
Xiao Chen ◽  
...  
Keyword(s):  
Solid Tumors ◽  
Meta Analysis ◽  
Prognostic Significance ◽  
Disease Free Survival ◽  
Pooled Analysis ◽  
Prognostic Role ◽  
Free Survival ◽  
Hazard Ratios ◽  
Human Solid Tumors

AbstractA consensus about the prognostic role of NIMA-related kinase 2 (NEK2) expression in various solid tumors has not been made yet. Thus, this meta-analysis aimed to systematically assess the prognostic role of NEK2 expression in patients with solid tumors. The eligible studies were identified through searching PubMed, Web of Science, and EMBASE. The hazard ratios (HRs) with their corresponding 95% confidence intervals (CIs) were used to evaluate the link between NEK2 overexpression and overall survival (OS) and disease-free survival/recurrence-free survival (DFS/RFS) of patients with solid tumors. A total of 17 studies with 4897 patients were included in this meta-analysis. Among these studies, all of them explored the association between NEK2 expression and OS of patients with solid tumors. Our pooled analysis indicated that NEK2 overexpression was significantly related to adverse OS (HR = 1.66; 95% CI: 1.38–2.00; P = 0.001). Additionally, there were six studies with 854 patients that investigated the association between NEK2 expression and DFS/RFS. Our pooled result indicated that there was a substantial relationship between NEK2 overexpression and poorer DFS/RFS (HR = 2.00; 95% CI: 1.61–2.48; P = 0.003). In conclusion, our meta-analysis indicated that NEK2 may be a useful predictor of prognosis and an effective therapeutic target in solid tumors. Nevertheless, more high-quality studies are warranted to further support our conclusions because of several limitations in our meta-analysis.

Prognostic role of high Bmi-1 expression in Asian and Caucasian patients with solid tumors: A meta-analysis

2014 ◽  
Vol 68 (8) ◽  
pp. 969-977 ◽  
Author(s):  
Yingjie Shao ◽  
Yiting Geng ◽  
Wendong Gu ◽  
Zhonghua Ning ◽  
Jingting Jiang ◽  
...  
Keyword(s):  
Solid Tumors ◽  
Meta Analysis ◽  
Prognostic Role ◽  
Caucasian Patients ◽  
High Bmi

scholarly journals Prognostic role of tumor-infiltrating CD57-positive lymphocytes in solid tumors: a meta-analysis

Oncotarget ◽  
2017 ◽  
Vol 9 (8) ◽  
pp. 8111-8119 ◽  
Author(s):  
Guoming Hu ◽  
Shimin Wang
Keyword(s):  
Solid Tumors ◽  
Meta Analysis ◽  
Prognostic Role

scholarly journals The Prognostic Role of Ribosomal Protein S6 Kinase 1 Pathway in Patients With Solid Tumors: A Meta-Analysis

2019 ◽  
Vol 9 ◽  
Author(s):  
Shuo Zhang ◽  
Binwu Hu ◽  
Xiao Lv ◽  
Songfeng Chen ◽  
Weijian Liu ◽  
...  
Keyword(s):  
Ribosomal Protein ◽  
Solid Tumors ◽  
Meta Analysis ◽  
Prognostic Role ◽  
S6 Kinase ◽  
Ribosomal Protein S6 ◽  
Ribosomal Protein S6 Kinase

scholarly journals Prognostic role of STAT3 in solid tumors: a systematic review and meta-analysis

Oncotarget ◽  
2016 ◽  
Vol 7 (15) ◽  
pp. 19863-19883 ◽  
Author(s):  
Pin Wu ◽  
Dang Wu ◽  
Lufeng Zhao ◽  
Lijian Huang ◽  
Gang Shen ◽  
...  
Keyword(s):  
Systematic Review ◽  
Solid Tumors ◽  
Meta Analysis ◽  
Prognostic Role

Prognostic role of PD-L1 in malignant solid tumors: a meta-analysis

2016 ◽  
pp. 0-0 ◽  
Author(s):  
Jung-Soo Pyo ◽  
Guhyun Kang ◽  
Jung Yeon Kim
Keyword(s):  
Solid Tumors ◽  
Meta Analysis ◽  
Prognostic Role

scholarly journals Tumor-Infiltrating Podoplanin+ Fibroblasts Predict Worse Outcome in Solid Tumors

2018 ◽  
Vol 51 (3) ◽  
pp. 1041-1050 ◽  
Author(s):  
Guoming Hu ◽  
Shimin Wang ◽  
Feng Xu ◽  
Qiannan Ding ◽  
Wei Chen ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Solid Tumors ◽  
Solid Tumor ◽  
Meta Analysis ◽  
Disease Free Survival ◽  
Clinicopathological Features ◽  
Immunohistochemical Method ◽  
Hazard Ratios ◽  
Human Solid Tumors

Background/Aims: Tumor-infiltrating fibroblasts are a heterogeneous population, and different subpopulations play differential roles in tumor microenvironment. However, the prognostic role of podoplanin+ fibroblasts in human solid tumors still remains controversial. Therefore, we performed the meta-analysis to better understand the role of this subpopulation in prognosis prediction for patients with solid tumor. Methods: We searched PubMed and EBSCO to identify the studies evaluating the association of intratumoral podoplanin+ fibroblast density detected by immunohistochemical method and overall survival (OS) and/or disease-free survival (DFS) in patients with solid tumor, then computed extracted data into hazard ratios for OS, DFS and clinicopathological features with STATA 12.0. Results: A total of 4883 patients from 29 published studies were incorporated into this meta-analysis. We found that podoplanin+ fibroblast infiltration significantly decreased OS and DFS in all types of solid tumors. In stratified analyses, podoplanin+ fibroblast infiltration was significantly associated with worse OS in cholangiocarcinoma, breast, lung and pancreatic cancer. And these cells were inversely associated with DFS in breast, lung and pancreatic cancer. In addition, high density of these cells significantly correlated with unfavorable clinicopathological features such as lymph node metastasis, TNM stage, lymphatic and vascular invasion of solid tumor. Conclusion: Podoplanin+ fibroblast infiltration leads to worse clinical outcome in solid tumors, implicating that it is a valuable prognostic biomarker and targeting it may have a potential for effective treatment.

scholarly journals Prognostic role of galectin-3 expression in patients with solid tumors: a meta-analysis of 36 eligible studies

2018 ◽  
Vol 18 (1) ◽  
Author(s):  
Yi Wang ◽  
Shiwei Liu ◽  
Ye Tian ◽  
Yamin Wang ◽  
Qijie Zhang ◽  
...  
Keyword(s):  
Solid Tumors ◽  
Meta Analysis ◽  
Prognostic Role ◽  
Galectin 3

scholarly journals Prognostic Role of Neutrophil-to-Lymphocyte Ratio in Solid Tumors: A Systematic Review and Meta-Analysis

2014 ◽  
Vol 106 (6) ◽  
Author(s):  
Arnoud J. Templeton ◽  
Mairéad G. McNamara ◽  
Boštjan Šeruga ◽  
Francisco E. Vera-Badillo ◽  
Priya Aneja ◽  
...  
Keyword(s):  
Systematic Review ◽  
Solid Tumors ◽  
Meta Analysis ◽  
Neutrophil To Lymphocyte Ratio ◽  
Prognostic Role ◽  
Lymphocyte Ratio

Prognostic role of pretreatment plasma fibrinogen in patients with solid tumors: A systematic review and meta-analysis

2015 ◽  
Vol 41 (10) ◽  
pp. 960-970 ◽  
Author(s):  
C. Perisanidis ◽  
A. Psyrri ◽  
E.E. Cohen ◽  
J. Engelmann ◽  
G. Heinze ◽  
...  
Keyword(s):  
Systematic Review ◽  
Solid Tumors ◽  
Meta Analysis ◽  
Plasma Fibrinogen ◽  
Prognostic Role
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