scholarly journals Focal lesions of the cerebral white matter in patients with arterial hypertension as evidenced by 5-year prospective study

2004 ◽  
Vol 10 (1) ◽  
pp. 23-25
Author(s):  
V. F. Mordovin ◽  
N. L. Afanasyeva ◽  
P. I. Lukyanenok ◽  
G. V. Semke
Keyword(s):  
Magnetic Resonance Imaging ◽  
White Matter ◽  
Arterial Hypertension ◽  
Brain Magnetic Resonance Imaging ◽  
White Matter Lesions ◽  
Cerebral White Matter ◽  
Resonance Imaging ◽  
Focal Lesions ◽  
Cerebral White Matter Lesions ◽  
Baseline Values

Studies were conducted in 58 patients (33 males and 25 females) aged 36 to 59 years who had arterial hypertension. 24-hour blood pressure (BP) monitoring and brain magnetic resonance imaging were performed in all the patients before and 5 years after the studies. Focal cerebral white matter lesions (FCWML) that had been absent before was found to appear in 15 (25%) patients; FCWML showed no changes in 12 (21%) patients. There was an increase in the number of FCWML in 17 (30%). The patients in whom FCWML appeared had significantly higher baseline values of BP and its time indices and, on repeated examination, they had only significantly higher time indices of BP. The findings suggest that arterial hypertension is a factor that enhances the likelihood of GCWML and that the use of 24-hour BP monitoring permits identification of a group of patients having a high risk for their appearance.

Cognitive Functioning and Magnetic Resonance Imaging in Chronic Fatigue

1995 ◽  
Vol 167 (1) ◽  
pp. 86-94 ◽  
Author(s):  
Helen Cope ◽  
Amanda Pernet ◽  
Brian Kendall ◽  
Anthony David
Keyword(s):  
Magnetic Resonance Imaging ◽  
White Matter ◽  
Magnetic Resonance ◽  
Cognitive Dysfunction ◽  
White Matter Lesions ◽  
Chronic Fatigue ◽  
Depressive Illness ◽  
Cerebral White Matter ◽  
Resonance Imaging ◽  
Fatigue Syndrome

BackgroundThis study examines whether cognitive dysfunction in chronic fatigue may be accounted for by depression and anxiety or is due to brain pathology evident on magnetic resonance imaging (MRI).MethodTwenty-six subjects with chronic fatigue, with and without coexisting depression, and 18 age-matched normal controls were recruited from primary care following a presumed viral illness six months previously. Comparison was made with 13 psychiatric controls with depressive illness on standardised cognitive tests. MRI determined the presence of cerebral white-matter lesions.ResultsNo substantial differences in performance were shown between subjects with chronic fatigue, most of whom met the criteria for chronic fatigue syndrome, and controls. Subjective cognitive dysfunction increased with psychopathology. White-matter lesions were found in a minority from all groups. Improvement in fatigue and depression coincided with improved performance on cognitive measures.ConclusionsSubjective complaints of cognitive impairment are a prominent feature of chronic fatigue, but objective cognitive and MRI abnormalities are not. Such complaints probably reflect psychopathology rather than a post-viral process.

Breakthrough Disease While on Multiple Sclerosis Immunomodulatory Therapy

2021 ◽  
pp. 55-56
Author(s):  
Jonathan L. Carter
Keyword(s):  
Magnetic Resonance Imaging ◽  
Multiple Sclerosis ◽  
Spinal Cord ◽  
White Matter ◽  
Magnetic Resonance ◽  
Disease Activity ◽  
Brain Magnetic Resonance Imaging ◽  
White Matter Lesions ◽  
Dimethyl Fumarate ◽  
Resonance Imaging

A 36-year-old woman with a history of relapsing-remitting multiple sclerosis was evaluated for new multiple sclerosis symptoms accompanied by new, enhancing, white matter lesions on brain magnetic resonance imaging. Her multiple sclerosis presented with L’hermitte sign when she was 24 years old. She had onset of bilateral lower extremity and left upper extremity tingling at age 26 years. Magnetic resonance imaging and cerebrospinal fluid examination at the time were supportive of the diagnosis of multiple sclerosis, and disease-modifying therapy was recommended by her neurologist. She initiated therapy with dimethyl fumarate at age 30 years after several further relapses. Surveillance magnetic resonance imaging showed new gadolinium-enhancing lesions on brain magnetic resonance imaging on each of 3 consecutive yearly scans. Urine culture and sensitivity tests were performed to rule out occult urinary tract infection; results of this testing were negative. magnetic resonance imaging of the brain concurrently showed new enhancing white matter lesions. The patient was diagnosed with clinical and radiographic breakthrough disease activity while receiving therapy for multiple sclerosis. The patient was treated with 5 days of intravenous methylprednisolone for her relapse. After discussion with the patient, it was decided to transition therapy from dimethyl fumarate to ocrelizumab infusions for her breakthrough disease activity. This decision was further supported by the patient’s concerns that she might be entering an early progressive phase of the disease. In patients with spinal-predominant multiple sclerosis, or with symptoms potentially indicating new spinal cord involvement, it may be necessary to include spinal cord imaging to assess for new disease activity.

scholarly journals Brain Magnetic Resonance Imaging White Matter Lesions Are Frequent in HTLV-I Carriers and Do Not Discriminate from HAM/TSP

2007 ◽  
Vol 23 (12) ◽  
pp. 1499-1504 ◽  
Author(s):  
Daniel J. Morgan ◽  
Marina F. Caskey ◽  
Cristiane Abbehusen ◽  
Jamary Oliveira-Filho ◽  
Cesar Araujo ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
White Matter ◽  
Magnetic Resonance ◽  
Brain Magnetic Resonance Imaging ◽  
White Matter Lesions ◽  
Resonance Imaging
Sign in / Sign up

Export Citation Format

Share Document