scholarly journals Perbandingan Efektivitas Cefazolin dan Ceftriaxone Sebagai Antibiotik Profilaksis Bedah Ortopedi Open Reduction Internal Fixation (ORIF) Fraktur Tertutup

Author(s):  
Nurul Latifah ◽  
Tri Murti Andayani ◽  
Zullies Ikawati

<p>Infeksi daerah operasi (IDO) merupakan infeksi yang terjadi hingga 30 hari setelah operasi atau satu tahun setelah operasi pada pasien yang menerima implan dan mempengaruhi sayatan atau jaringan dalam di lokasi operasi. Sefalosporin golongan pertama yaitu cefazolin merupakan antibiotik pilihan sebagai proflaksis bedah karena merupakan antibiotik spektrum luas, memiliki profil farmakokinetik yang baik, angka kejadian efek samping yang kecil, serta harga relatif murah. Pada praktek klinis, ceftriaxone banyak digunakan karena merupakan antibiotik yang lebih murah dibanding cefazolin. Tujuan penelitian ini adalah untuk mengetahui efektivitas dan keamanan cefazolin dibandingkan dengan ceftriaxone sebagai antibiotik profilaksis pasien bedah ortopedi <em>Open Reduction Internal Fixation </em>(ORIF) fraktur tertutup. Penelitian ini merupakan penelitian observasional analitik dengan rancangan kohort retrospektif dari rekam medis pasien yang menjalani ORIF fraktur tertutup periode 1 Januari hingga 31 Desember 2020 di sebuah rumah sakit swasta tipe B di Yogyakarta. Luaran klinis yang diamati dalam penelitian ini adalah kejadian IDO dan kejadian efek samping selama 90 hari sejak pasien dilakukan prosedur bedah<em>. </em>Terdapat 59 pasien yang menjalani ORIF yang masuk kriteria inklusi pada penelitian ini yang terbagi mejadi dua kelompok yaitu pasien yang mendapat antibiotik profilaksis cefazolin (n=25) dan ceftriaxone (n=34). Hasil dari penelitian ini menunjukkan bahwa angka kejadian IDO pada pasien yang menjalani ORIF fraktur tertutup sebesar 5,08% dari total subjek atau 8,82% dari  yang diberikan ceftriaxone dan 0% dari pasien yang diberikan cefazolin. Perbedaan probabilitas kejadian IDO pada pemberian ceftriaxone sebagai antibiotik profilaksis tidak berbeda bermakna dengan pemberian cefazolin (RR = 1,097; 95% CI = 0,988 – 1,218; p = 0,064).</p>

Author(s):  
Michelle Zeidan ◽  
Andrew R. Stephens ◽  
Chong Zhang ◽  
Angela P. Presson ◽  
Andrew R. Tyser ◽  
...  

2017 ◽  
Vol 2017 ◽  
pp. 1-7 ◽  
Author(s):  
Wei Zhao ◽  
Yuhui Zhang ◽  
Dongni Johansson ◽  
Xingyu Chen ◽  
Fang Zheng ◽  
...  

Objective. The study aims to compare minimally invasive percutaneous plate osteosynthesis (MIPO) and open reduction internal fixation (ORIF) in the treatment of proximal humeral fracture in elder patients. Method. PubMed, Medline, EMbase, Ovid, Cochrane Library, China National Knowledge Infrastructure (CNKI), Wangfang, and VIP Database for Chinese Technical Periodicals were searched to identify all relevant studies from inception to October 2016. Data were analyzed with Cochrane Collaboration’s Review Manage 5.2. Results. A total of 630 patients from 8 publications were included in the systematic review and meta-analysis. The pooled results showed that MIPO was superior to ORIF in the treatment of proximal humeral fracture in elder patients. It was reflected in reducing blood loss, operation time, postoperative pain, or fracture healing time of the surgery and in improving recovery of muscle strength. Concerning complications, no significant difference was seen between MIPO and ORIF. Conclusion. The MIPO was more suitable than ORIF for treating proximal humeral fracture in elder patients.


2018 ◽  
Vol 3 (3) ◽  
pp. 2473011418S0013
Author(s):  
Ming-Zhu Zhang ◽  
Guang-rong Yu ◽  
Mark Myerson

Category: Trauma Introduction/Purpose: The first tarsometatarsal (TMT) joint is very crucial for midfoot stability. To address its importance, retrospective analyses of treatment for the first TMT joint dislocation with Lisfranc injury was performed in a multi-center manner. Comparison of open reduction internal fixation (ORIF) and primary arthrodesis was conducted for the injury. Methods: This multi-center study was involved ten clinical institutions in different area of China. .From January 2003 to June 2015, 126 Lisfranc injuries with first TMT joint dislocation underwent surgical intervention. Of this group, forty one (32.5%) feet were first TMT joint dislocation only. Eighty five feet were first TMT joint dislocation and fractures. They were 76 males (60.3%) and 50 females (39.7%) with a mean age of 45.5 (range, 20-87) years. The duration from injury to surgery is 11.7 (range, 4-26) days. Two groups were divided by surgery methods as open reduction internal fixation (ORIF) group and primary arthrodesis group. Ninety two patients were performed by ORIF, while primary arthrodesis group including 34 cases. Outcome measures included clinical examination, radiographs, AOFAS ankle-hindfoot scores, visual analogue scale (VAS) and SF-36 scores. Complications and revision rate were analyzed as well. Results: 126 patients were followed up for 29.5 months. At 1.5 years postoperatively, the AOFAS score was 79 and 85 in ORIF group and arthrodesis group.The VAS score was 3.1 separately in two groups.The mean Physical Functioning sores of SF-36 was 80.3 points and 83.5• points. The Bodily Pain score of SF-36 was 76.1 points and 84.6• points.Redislocation of first tarsometarsal joint were observed in 16 cases among ORIF group.36 patients in ORIF group had pain in midfoot, eight of them had persistent pain with the development of deformity or osteoarthrosis.No redislocation and no hardware failure was identified in arthrodesis group Conclusion: Primary stable arthrodesis of the first ray gives a better short and medium term outcome than open reduction and internal fixation for Lisfranc injury with the first ray dislocation. Possible complication and revision could be avoided by primary arthrodesis for dislocated first ray injuries.


Sign in / Sign up

Export Citation Format

Share Document