SURGICAL OUTCOME OF TYPE I TYMPANOPLASTY WITH OR WITHOUT    MASTOIDECTOMY IN DRY MUCOSAL CHRONIC OTITIS MEDIA:    A RANDOMIZED CONTROLLED TRIAL

Abstract Background Interorgan communication networks established during exercise in several different tissues can be mediated by several exercise-induced factors. Therefore, the present study aimed to investigate the effects of resistance-type training using elastic band-induced changes of myomiRs (i.e., miR-206 and miR-133), vitamin D, CTX-I, ALP, and FRAX® score in elderly women with osteosarcopenic obesity (OSO). Methods In this randomized controlled trial, 63 women (aged 65–80 years) with Osteosarcopenic Obesity were recruited and assessed, using a dual-energy X-ray absorptiometry instrument. The resistance-type training via elastic bands was further designed three times per week for 12-weeks. The main outcomes were Fracture Risk Assessment Tool score, bone mineral content, bone mineral density, vitamin D, alkaline phosphatase, C-terminal telopeptides of type I collagen, expression of miR-206 and miR-133. Results There was no significant difference between the study groups in terms of the Fracture Risk Assessment Tool score (p = 0.067), vitamin D (p = 0.566), alkaline phosphatase (p = 0.334), C-terminal telopeptides of type I collagen (p = 0.067), microR-133 (p = 0.093) and miR-206 (p = 0.723). Conclusion Overall, the results of this study illustrated 12-weeks of elastic band resistance training causes a slight and insignificant improvement in osteoporosis markers in women affected with Osteosarcopenic Obesity. Trial registration Randomized controlled trial (RCT) (Iranian Registry of Clinical Trials, trial registration number: IRCT20180627040260N1. Date of registration: 27/11/2018.

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Comparative Study Between Trans-perineal Repair With or Without Limited Internal Sphincterotomy in the Treatment of Type I Anterior Rectocele: a Randomized Controlled Trial

Journal of Gastrointestinal Surgery ◽

10.1007/s11605-016-3299-4 ◽

2016 ◽

Vol 21 (2) ◽

pp. 380-388 ◽

Cited By ~ 9

Author(s):

Mohamed Youssef ◽

Sameh Hany Emile ◽

Waleed Thabet ◽

Hossam Ayman Elfeki ◽

Alaa Magdy ◽

...

Keyword(s):

Randomized Controlled Trial ◽

Comparative Study ◽

Controlled Trial ◽

Type I ◽

Internal Sphincterotomy ◽

Perineal Repair ◽

Randomized Controlled ◽

Anterior Rectocele

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Efficacy of 10-valent pneumococcal non-typeable Haemophilus influenzae protein D conjugate vaccine against acute otitis media and nasopharyngeal carriage in Panamanian children – A randomized controlled trial

Human Vaccines & Immunotherapeutics ◽

10.1080/21645515.2017.1287640 ◽

2017 ◽

Vol 13 (6) ◽

pp. 1213-1228 ◽

Cited By ~ 15

Author(s):

Xavier Sáez-Llorens ◽

Stella Rowley ◽

Digna Wong ◽

Mirna Rodríguez ◽

Arlene Calvo ◽

...

Keyword(s):

Randomized Controlled Trial ◽

Haemophilus Influenzae ◽

Otitis Media ◽

Conjugate Vaccine ◽

Controlled Trial ◽

Acute Otitis Media ◽

Nasopharyngeal Carriage ◽

Randomized Controlled

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Low frequency maintenance therapy with imiglucerase in adult type I Gaucher disease: a prospective randomized controlled trial

Haematologica ◽

10.3324/haematol.10635 ◽

2007 ◽

Vol 92 (2) ◽

pp. 215-221 ◽

Cited By ~ 17

Author(s):

M. de Fost ◽

J. M.F.G. Aerts ◽

J. E.M. Groener ◽

M. Maas ◽

E. M. Akkerman ◽

...

Keyword(s):

Randomized Controlled Trial ◽

Maintenance Therapy ◽

Gaucher Disease ◽

Controlled Trial ◽

Low Frequency ◽

Type I ◽

Adult Type ◽

Randomized Controlled ◽

Prospective Randomized Controlled Trial

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A Randomized, Controlled Trial Comparing Autologous Matrix-Induced Chondrogenesis (AMIC®) to Microfracture: Analysis of 1- and 2-Year Follow-Up Data of 2 Centers

The Open Orthopaedics Journal ◽

10.2174/1874325001307010133 ◽

2013 ◽

Vol 7 (1) ◽

pp. 133-143 ◽

Cited By ~ 73

Author(s):

Sven Anders ◽

Martin Volz ◽

Hubert Frick ◽

Jörg Gellissen

Keyword(s):

Randomized Controlled Trial ◽

Clinical Outcomes ◽

Controlled Trial ◽

Collagen Type I ◽

Cartilage Defects ◽

Type I ◽

Randomized Controlled ◽

First Results ◽

Post Operation

Microfracture (MFx) is currently the recommended option for the treatment of small cartilage defects but is not regarded as suitable for the treatment of defects larger than 2.5 cm2. To extent its applicability to medium-sized defects MFx has been combined with a collagen type I/III matrix (Chondro-Gide®). This technique is called Autologous Matrix-Induced Chondrogenesis (AMIC®) and meanwhile a clinically established treatment option for localized full-thickness small- to medium-sized cartilage defects. Despite its more spreading clinical use, clinical data published so far are limited to mainly case report series.In this study, we report the first results of a randomized, controlled trial assessing the efficacy and safety of AMIC®versus MFx. Patients enrolled in 2 centers were included in this analysis. 38 patients (aged 21-50 years, mean defect size 3.4 cm2) were randomized and treated either with MFx, with sutured AMIC®or glued AMIC®. Clinical outcomes (modified Cincinnati and ICRS score) could be assessed in 30 patients at 1-year and 27 patients at 2-years post-operation. Improvements in both scores were seen at 1-and 2-years post-operation, irrespective of the technique used. MRI assessment revealed a satisfactory and homogenous defect filling in the majority of patients. No treatment-related adverse events were reported.This interim analysis confirms the mid-term results for AMIC®reported in literature. It demonstrates clearly that clinical outcomes at 1-year post-operation are maintained at 2-years. Therefore we consider enhancing MFx with Chondro-Gide®is a valid and safe cartilage repair option for small- to medium-sized cartilage defects of the knee.

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