Association study between polymorphisms of XRCC1, hOGG1 in DNA repair gene and the risk of endometrial carcinoma: a meta-analysis

Abstract Objective The association of DNA repair gene XRCC1, hOGG1 polymorphisms with susceptibility to endometrial carcinoma (EC) have been extensively studied with inconsistent results. The objective of this study was to clarify this issue by a comprehensive review and meta-analysis. Methods English (PubMed, Medline, Embase) and Chinese (CNKI, wanfang) electric databases were searched to collect a case-control study on the association between XRCC1 or hOGG1 gene polymorphisms and endometrial carcinoma. The retrieval time was from the database until may 1th, 2019. According to inclusion and exclusion criteria, relevant data of the final included literature were extracted and STATA 11.0 software was used for meta analysis. Results A total of 8 references meeting the inclusion criteria were included for analysis from the 243 retrieved literatures. The Arg399Gln polymorphism at the XRCC1 gene was associated with increased susceptibility to endometrial carcinoma (OR=1.36, 95%CI=1.23~1.51, P<0.001) in the overall population, the same results were shown in the subgroup analysis of Caucasians (OR=1.44, 95%CI=1.29~1.61, P<0.001). Ser326Cys polymorphism of the hOGG1 gene also increases the risk of endometrial carcinoma in Caucasians (OR=1.54, 95%CI=1.34~1.76, P=0.001). No publication bias was detected in this meta-analysis. Conclusions This meta-analysis provided evidence that the Arg399Gln polymorphism of DNA repair gene XRCC1 may increase risk of endometrial carcinoma, especially in the Caucasian. Moreover, Ser326Cys polymorphism of hOGG1 increase endometrial carcinoma risk in the Caucasian.

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The Association Between the XRCC1 Arg399Gln Polymorphism and the Risk of Head and Neck Cancer: An Updated Meta-Analysis Including 14586 Subjects

Technology in Cancer Research & Treatment ◽

10.1177/15330338211033060 ◽

2021 ◽

Vol 20 ◽

pp. 153303382110330

Author(s):

Shitong Xia ◽

Sihai Wu ◽

Minghao Wang

Keyword(s):

Dna Repair ◽

Head And Neck Cancer ◽

Head And Neck ◽

Neck Cancer ◽

Meta Analysis ◽

Repair Gene ◽

Xrcc1 Arg399gln ◽

Dna Repair Gene ◽

Subgroup Analyses ◽

Arg399gln Polymorphism

Background: Accumulated evidence shows that DNA repair gene X-ray repair cross complementing group 1 (XRCC1) may determine individual susceptibility to head and neck cancer (HNC) as a major DNA repair gene. However, the results from previous studies have been conflictive and inconsistent. In order to more accurately estimate and integrate the association between XRCC1 Arg399Gln polymorphism and HNC risk, we conducted a meta-analysis including 14586 subjects. Methods: In this meta-analysis, literatures were collected up until September 15, 2020 through multifarious retrieval strategies by searching through electronic databases of PubMed, Cochrane Library, EMBASE, Medline, Web of Science and CNKI. The association between the XRCC1 Arg399Gln polymorphism and HNC was analyzed through calculating summary odds ratios (OR) and 95% confidence intervals (CI). Results: Thirty-one studies consisting of 6025 cases and 8561 controls were identified and analyzed. No significant association between XRCC1 Arg399Gln polymorphisms and HNC risk was found under the allelic (OR = 0.94, 95% CI: 0.82-1.07, P = 0.35), homozygous (OR = 0.99, 95% CI: 0.81-1.21, P = 0.91), heterozygous (OR = 1.01, 95% CI: 0.90-1.13, P = 0.91), dominant (OR = 1.05, 95% CI: 0.85-1.29, P = 0.67) or recessive (OR = 0.93, 95% CI: 0.80-1.08, P = 0.35) genetic models in the overall comparison. In addition, subgroup analyses according to tumor site also displayed no significant association between XRCC1 Arg399Gln polymorphisms and HNC risk. However, subgroup analyses based on ethnicity indicated that HNC risk was significantly related to Arg399Gln genetic heterozygous model (OR = 1.21, 95%CI: 1.04-1.42, P = 0.02) and dominant model (OR = 1.27, 95%CI: 1.02-1.60, P = 0.04) in Caucasians populations. Conclusion: The results from this meta-analysis suggest that the XRCC1 Arg399Gln variants (Arg/Gln and Arg/Arg+Arg/Gln) may contribute to high HNC risk among Caucasians. Further well-designed studies and larger sample sizes are needed to validate our findings.

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