Performance and Feasibility of Therapeutic Vibrating Mesh Nebulizer for Ventilation Lung Scan

Abstract This study aimed to evaluate the performance of a therapeutic vibrating mesh-type nebulizer for the pulmonary delivery of radioaerosols for lung scintigraphy in healthy subjects. Six healthy subjects (mean age of 28.7 ± 6.2 y) inhaled 2 mL of Tc-99m diethylenetriaminepentaacetic acid (DTPA) and normal saline solution (20 mCi) via the therapeutic vibrating mesh nebulizer (DK010, DELBio, Taipei, Taiwan). The nebulizer’s mass median aerodynamic diameter (MMAD) is between 2.3 μm and 5.0 μm (3.47 ± 0.37 μm) and the nebulization rate is greater than 0.2 ml/min. Scintigraphy was performed to count radioaerosols in the regions of interest to determine the total and regional lung deposition and extrathoracic airway deposition of aerosols, penetration of aerosols, and radioactivity count balance. The total lung deposition of aerosols was 21.2 ± 5.2% (% ex-valve dose), 27.4 ± 8.0% (% ex-device dose) and 13.8 ± 4.1% (% initial dose) in nebulizer. The extrathoracic airway deposition was 4.8 ± 1.1%. The radioactivity count balance was 5.4 ± 3.0%. The ratio of outer vs inner lung deposition (O/I ratio, or penetration index) was 1.89 ± 0.55. The delivery efficiency and the penetration of aerosols to the peripheral lung achieved by the DELBio DK010 vibrating mesh-type nebulizer are similar to the commercialized jet-type nebulizers dedicated for radioaerosol lung scintigraphy nebulizer. The therapeutic vibrating mesh-type nebulizer (DELBio DK010) is feasible for radionuclide lung ventilation scintigraphy.

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Lung Deposition of the Dry Powder Fixed Combination Beclometasone Dipropionate Plus Formoterol Fumarate Using NEXThaler® Device in Healthy Subjects, Asthmatic Patients, and COPD Patients

Journal of Aerosol Medicine and Pulmonary Drug Delivery ◽

10.1089/jamp.2016.1359 ◽

2018 ◽

Vol 31 (5) ◽

pp. 269-280 ◽

Cited By ~ 2

Author(s):

Johann Christian Virchow ◽

Gianluigi Poli ◽

Christiane Herpich ◽

Claudius Kietzig ◽

Hilke Ehlich ◽

...

Keyword(s):

Healthy Subjects ◽

Fixed Combination ◽

Lung Deposition ◽

Dry Powder ◽

Asthmatic Patients ◽

Copd Patients ◽

Formoterol Fumarate

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Effects of positive expiratory pressure on pulmonary clearance of aerosolized technetium-99m-labeled diethylenetriaminepentaacetic acid in healthy individuals

Jornal Brasileiro de Pneumologia ◽

10.1590/s1806-37562015000000320 ◽

2016 ◽

Vol 42 (6) ◽

pp. 404-408

Author(s):

Isabella Martins de Albuquerque ◽

◽

Dannuey Machado Cardoso ◽

Paulo Ricardo Masiero ◽

Dulciane Nunes Paiva ◽

...

Keyword(s):

Membrane Permeability ◽

Spontaneous Breathing ◽

Healthy Subjects ◽

Diethylenetriaminepentaacetic Acid ◽

Healthy Individuals ◽

Lung Scintigraphy ◽

Technetium 99M ◽

Pulmonary Clearance ◽

Two Stages ◽

Positive Expiratory Pressure

ABSTRACT Objective: To evaluate the effects of positive expiratory pressure (PEP) on pulmonary epithelial membrane permeability in healthy subjects. Methods: We evaluated a cohort of 30 healthy subjects (15 males and 15 females) with a mean age of 28.3 ± 5.4 years, a mean FEV1/FVC ratio of 0.89 ± 0.14, and a mean FEV1 of 98.5 ± 13.1% of predicted. Subjects underwent technetium-99m-labeled diethylenetriaminepentaacetic acid (99mTc-DTPA) radioaerosol inhalation lung scintigraphy in two stages: during spontaneous breathing; and while breathing through a PEP mask at one of three PEP levels-10 cmH2O (n = 10), 15 cmH2O (n = 10), and 20 cmH2O (n = 10). The 99mTc-DTPA was nebulized for 3 min, and its clearance was recorded by scintigraphy over a 30-min period during spontaneous breathing and over a 30-min period during breathing through a PEP mask. Results: The pulmonary clearance of 99mTc-DTPA was significantly shorter when PEP was applied-at 10 cmH2O (p = 0.044), 15 cmH2O (p = 0.044), and 20 cmH2O (p = 0.004)-in comparison with that observed during spontaneous breathing. Conclusions: Our findings indicate that PEP, at the levels tested, is able to induce an increase in pulmonary epithelial membrane permeability and lung volume in healthy subjects.

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