scholarly journals Establishment and Evaluation of a Risk-prediction Model for HBP in Elderly Patients With NAFLD From a Health Management Perspective

Author(s):  
Xin Luo ◽  
An Zhang ◽  
Hong Pan ◽  
Xinxin Shen ◽  
Baocheng Liu ◽  
...  

Abstract Objective: Elderly patients with nonalcoholic fatty liver disease (NAFLD) are at a higher risk of developing high blood pressure (HBP) and having a low quality of life. This study established an effective, individualised, early HBP risk-prediction model and proposed health management advice for the ³60 patients with NAFLD in Shanghai, China.Methods: Questionnaire surveys, physical examinations, and biochemical tests were conducted on 7,319 cases of sample data. Risk factors were screened using the least absolute shrinkage and selection operator (Lasso) model and random forest (RF) model. A risk-prediction model was established using logistic regression analysis and dynamic nomogram was drawn. The model was evaluated for discrimination, calibration, and clinical applicability using receiver operating characteristic curves (ROC), calibration curves, decision curve analysis (DCA), net reclassification index (NRI), and external validation.Results: The results suggested the model showed moderate predictive ability. The area under curve (AUC) of internal validation was 0.707 (95% CI: 0.688-0.727), the external validation AUC was 0.688 (95% CI: 0.672-0.705). The calibration plots showed good calibration, the risk threshold of the decision curve was 30-56%, and the NRI value was 0.109.Conclusion: This HBP risk factor model may be used in clinical practice to predict the HBP risk in NAFLD patients.

2017 ◽  
Vol 128 (5) ◽  
pp. 1140-1145 ◽  
Author(s):  
Japke F. Petersen ◽  
Martijn M. Stuiver ◽  
Adriana J. Timmermans ◽  
Amy Chen ◽  
Hongzhen Zhang ◽  
...  

Authorea ◽  
2020 ◽  
Author(s):  
Evangelia Christodoulou ◽  
Shabnam Bobdiwala ◽  
Christopher Kyriacou ◽  
Jessica Farren ◽  
Nicola Mitchell Jones ◽  
...  

2016 ◽  
Vol 19 (3) ◽  
pp. 97-101
Author(s):  
Hyo Jung Ko ◽  
Ki Hyun Kim ◽  
Si Hak Lee ◽  
Cheol Woong Choi ◽  
Su Jin Kim ◽  
...  

2013 ◽  
Vol 16 (3) ◽  
pp. A12
Author(s):  
T. Matsuda ◽  
I. Tonnu-Mihara ◽  
Y. Yuan ◽  
P. Hines ◽  
S.L. Saab ◽  
...  

2021 ◽  
Author(s):  
Yi Du ◽  
Hanxue Wang ◽  
Wenjuan Cui ◽  
Hengshu Zhu ◽  
Yunchang Guo ◽  
...  

BACKGROUND Foodborne disease is one of the common threats to human health worldwide, leading to millions of deaths every year. Thus, the accurate prediction of future foodborne disease risk is very urgent and of great significance for public health management. OBJECTIVE We aimed to design a spatial temporal risk prediction model suitable for foodborne diseases to predict the future foodborne disease risks in various regions, so as to provide guidance for the prevention and control of foodborne diseases. METHODS We design a novel end-to-end framework to predict the foodborne disease risk by using a multi-graph structural LSTM neural network, which can utilize the encoder-decoder structure to achieve multi-step prediction. In particular, to capture the multiple spatial correlations, we divide regions by administrative area and construct the adjacent graph with different metrics, including the proximity of regions, the similarity of historical data, the similarity of regional function and the similarity of foodborne disease exposure food. Furthermore, we also integrate the attention mechanism in both spatial and temporal dimensions and external factors to refine the prediction accuracy. RESULTS We validate our model with extensive experiments on a long-term real-world foodborne disease dataset, ranging from 2015 to 2019 in multiple provinces of China, where the experimental results clearly demonstrate that our approach can outperform other state-of-the-art baselines with a significant margin. CONCLUSIONS Our proposed spatial temporal risk prediction model of foodborne diseases can take into account the spatial temporal characteristics of foodborne disease data and provide a certain degree of precision for future disease spatial temporal risk prediction, thereby providing support for the prevention and risk assessment of foodborne disease.


2016 ◽  
Vol 19 (7) ◽  
pp. A809
Author(s):  
SR Dorajoo ◽  
V See ◽  
CT Chan ◽  
ZY Tan ◽  
N Koomanan ◽  
...  

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