scholarly journals Recent epidemiology of patients with Gastro-Entero-Pancreatic Neuroendocrine Neoplasms (GEP-NEN) in Japan: a population-based study

2020 ◽  
Author(s):  
Toshihiko Masui ◽  
Tetsuhide Ito ◽  
Izumi Komoto ◽  
Shinji Uemoto
Keyword(s):  
Cancer Registry ◽  
Population Data ◽  
Population Based ◽  
National Registry ◽  
Neuroendocrine Neoplasms ◽  
Population Based Study ◽  
National Cancer Registry ◽  
Exact Etiology ◽  
Using Data ◽  
Population Based Registry

Abstract Background: The worldwide prevalence and incidence of neuroendocrine neoplasms (NEN) have been increasing recently, although few studies have analyzed data on the current situation of NENs in Japan. Here, the Japan Neuroendocrine Tumor Society (JNETS) planned to investigate the recent incidence and distribution of these tumors using data from the national cancer registry started in 2016. This study examined the incidence and distribution of primary sites as well as disease progression from this population-based registry. Methods: A retrospective, population-based study using data from the national cancer registry in Japan (NCR) was conducted to evaluate patients with gastro-entero-pancreatic NEN (GEP-NEN) in 2016. Associated population data were used to determine annual age-adjusted incidences. Results: A total of 6735 individuals were diagnosed with GEP-NEN in Japan in 2016. Annual onset incidence was 0.70/100,000 for pancreatic NEN and 2.84/100,000 for gastrointestinal NEN. NEN in the ileum accounted for only 1% of total GEP-NENs in Japan. Most NENs in the esophagus or lungs were neuroendocrine carcinomas (NECs), while the majority of those in the duodenum, ileum, appendix and rectum were grade 1 neuroendocrine tumors (NETs). Median age at initial diagnosis was in between 60 to 65. Initial progression of the tumor was mostly limited to local for tumors in the duodenum, appendix and rectum, while those in the esophagus, stomach and colon tended to show distant metastasis. In Japan, initial treatment for GEP-NENs was resection even if the tumor was NEC.Conclusions: This is the first report of a national registry-based incidence and distribution of GEP-NEN in Japan. These data will serve as an important first step to determining the exact etiology and trends for this pathology in Japan.

scholarly journals Recent epidemiology of patients with Gastro-Entero-Pancreatic Neuroendocrine Neoplasms (GEP-NEN) in Japan: a population-based study

2020 ◽  
Author(s):  
Toshihiko Masui ◽  
Tetsuhide Ito ◽  
Izumi Komoto ◽  
Shinji Uemoto ◽  
project study group
Keyword(s):  
Cancer Registry ◽  
Population Data ◽  
Population Based ◽  
National Registry ◽  
Neuroendocrine Neoplasms ◽  
Population Based Study ◽  
National Cancer Registry ◽  
Exact Etiology ◽  
Using Data ◽  
Population Based Registry

Abstract Background: The worldwide prevalence and incidence of neuroendocrine neoplasms (NEN) have been increasing recently, although few studies have analyzed data on the current situation of NENs in Japan. Here, the Japan Neuroendocrine Tumor Society (JNETS) planned to investigate the recent incidence and distribution of these tumors using data from the national cancer registry started in 2016. This study examined the incidence and distribution of primary sites as well as rate of advanced disease from this population-based registry.Methods: A retrospective, population-based study using data from the national cancer registry in Japan (NCR) was conducted to evaluate patients with gastro-entero-pancreatic NEN (GEP-NEN) in 2016. Associated population data were used to determine annual age-adjusted incidences.Results: A total of 6735 individuals were diagnosed with GEP-NEN in Japan in 2016. Annual onset incidence was 0.70/100,000 for pancreatic NEN and 2.84/100,000 for gastrointestinal NEN. NEN in the ileum accounted for only 1% of total GEP-NENs in Japan. Most NENs in the esophagus or lungs were neuroendocrine carcinomas (NECs), while the majority of those in the duodenum, ileum, appendix and rectum were grade 1 neuroendocrine tumors (NETs). Median age at initial diagnosis was in between 60 to 65. Tumors in the duodenum, appendix and rectum were mostly limited to local, while those in the esophagus, stomach and colon tended to show distant metastasis. In Japan, initial treatment for GEP-NENs was resection even if the tumor was NEC.Conclusions: This is the first report of a national registry-based incidence and distribution of GEP-NEN in Japan. These data will serve as an important first step to determining the exact etiology and trends for this pathology in Japan.

scholarly journals Recent epidemiology of patients with Gastro-Entero-Pancreatic Neuroendocrine Neoplasms (GEP-NEN) in Japan: a population-based study

2020 ◽  
Author(s):  
Toshihiko Masui ◽  
Tetsuhide Ito ◽  
Izumi Komoto ◽  
Shinji Uemoto ◽  
project study group
Keyword(s):  
Cancer Registry ◽  
Population Data ◽  
Population Based ◽  
National Registry ◽  
Neuroendocrine Neoplasms ◽  
Population Based Study ◽  
National Cancer Registry ◽  
Exact Etiology ◽  
Using Data ◽  
Population Based Registry

Abstract Background: The worldwide prevalence and incidence of neuroendocrine neoplasms (NEN) have been increasing recently, although few studies have analyzed data on the current situation of NENs in Japan. Here, the Japan Neuroendocrine Tumor Society (JNETS) planned to investigate the recent incidence and distribution of these tumors using data from the national cancer registry started in 2016. This study examined the incidence and distribution of primary sites as well as rate of advanced disease from this population-based registry.Methods: A retrospective, population-based study using data from the national cancer registry in Japan (NCR) was conducted to evaluate patients with gastro-entero-pancreatic NEN (GEP-NEN) in 2016. Associated population data were used to determine annual age-adjusted incidences.Results: A total of 6735 individuals were diagnosed with GEP-NEN in Japan in 2016. Annual onset incidence was 0.70/100,000 for pancreatic NEN and 2.84/100,000 for gastrointestinal NEN. NEN in the ileum accounted for only 1% of total GEP-NENs in Japan. Most NENs in the esophagus or lungs were neuroendocrine carcinomas (NECs), while the majority of those in the duodenum, ileum, appendix and rectum were grade 1 neuroendocrine tumors (NETs). Median age at initial diagnosis was in between 60 to 65. Tumors in the duodenum, appendix and rectum were mostly limited to local, while those in the esophagus, stomach and colon tended to show distant metastasis. In Japan, initial treatment for GEP-NENs was resection even if the tumor was NEC.Conclusions: This is the first report of a national registry-based incidence and distribution of GEP-NEN in Japan. These data will serve as an important first step to determining the exact etiology and trends for this pathology in Japan.

scholarly journals Recent epidemiology of patients with Gastro-Entero-Pancreatic Neuroendocrine Neoplasms (GEP-NEN) in Japan: a population-based study

2020 ◽  
Author(s):  
Toshihiko Masui ◽  
Tetsuhide Ito ◽  
Izumi Komoto ◽  
Shinji Uemoto
Keyword(s):  
Cancer Registry ◽  
Population Data ◽  
Population Based ◽  
National Registry ◽  
Neuroendocrine Neoplasms ◽  
Population Based Study ◽  
National Cancer Registry ◽  
Exact Etiology ◽  
Using Data ◽  
Population Based Registry

Abstract Background: The worldwide prevalence and incidence of neuroendocrine neoplasms (NEN) have been increasing recently, although few studies have analyzed data on the current situation of NENs in Japan. Here, the Japan Neuroendocrine Tumor Society (JNETS) planned to investigate the recent incidence and distribution of these tumors using data from the national cancer registry started in 2016. This study examined the incidence and distribution of primary sites as well as rate of advanced disease from this population-based registry. Methods: A retrospective, population-based study using data from the national cancer registry in Japan (NCR) was conducted to evaluate patients with gastro-entero-pancreatic NEN (GEP-NEN) in 2016. Associated population data were used to determine annual age-adjusted incidences. Results: A total of 6735 individuals were diagnosed with GEP-NEN in Japan in 2016. Annual onset incidence was 0.70/100,000 for pancreatic NEN and 2.84/100,000 for gastrointestinal NEN. NEN in the ileum accounted for only 1% of total GEP-NENs in Japan. Most NENs in the esophagus or lungs were neuroendocrine carcinomas (NECs), while the majority of those in the duodenum, ileum, appendix and rectum were grade 1 neuroendocrine tumors (NETs). Median age at initial diagnosis was in between 60 to 65. Tumors in the duodenum, appendix and rectum were mostly limited to local, while those in the esophagus, stomach and colon tended to show distant metastasis. In Japan, initial treatment for GEP-NENs was resection even if the tumor was NEC.Conclusions: This is the first report of a national registry-based incidence and distribution of GEP-NEN in Japan. These data will serve as an important first step to determining the exact etiology and trends for this pathology in Japan.

scholarly journals Recent epidemiology of patients with Gastro-Entero-Pancreatic Neuroendocrine Neoplasms (GEP-NEN) in Japan: a population-based study

2020 ◽  
Author(s):  
Toshihiko Masui ◽  
Tetsuhide Ito ◽  
Izumi Komoto ◽  
Shinji Uemoto ◽  
JNETS project study group
Keyword(s):  
Cancer Registry ◽  
Population Data ◽  
Population Based ◽  
National Registry ◽  
Neuroendocrine Neoplasms ◽  
Population Based Study ◽  
National Cancer Registry ◽  
Exact Etiology ◽  
Using Data ◽  
Population Based Registry

Abstract Background: The worldwide prevalence and incidence of neuroendocrine neoplasms (NEN) have been increasing recently, although few studies have analyzed data on the current situation of NENs in Japan. Here, the Japan Neuroendocrine Tumor Society (JNETS) planned to investigate the recent incidence and distribution of these tumors using data from the national cancer registry started in 2016. This study examined the incidence and distribution of primary sites as well as rate of advanced disease from this population-based registry.Methods: A retrospective, population-based study using data from the national cancer registry in Japan (NCR) was conducted to evaluate patients with gastro-entero-pancreatic NEN (GEP-NEN) in 2016. Associated population data were used to determine annual age-adjusted incidences.Results: A total of 6735 individuals were diagnosed with GEP-NEN in Japan in 2016. Annual onset incidence was 0.70/100,000 for pancreatic NEN and 2.84/100,000 for gastrointestinal NEN. NEN in the ileum accounted for only 1% of total GEP-NENs in Japan. Most NENs in the esophagus or lungs were neuroendocrine carcinomas (NECs), while the majority of those in the duodenum, ileum, appendix and rectum were grade 1 neuroendocrine tumors (NETs). Median age at initial diagnosis was in between 60 to 65. Tumors in the duodenum, appendix and rectum were mostly limited to local, while those in the esophagus, stomach and colon tended to show distant metastasis. In Japan, initial treatment for GEP-NENs was resection even if the tumor was NEC.Conclusions: This is the first report of a national registry-based incidence and distribution of GEP-NEN in Japan. These data will serve as an important first step to determining the exact etiology and trends for this pathology in Japan.

scholarly journals Recent epidemiology of patients with gastro-entero-pancreatic neuroendocrine neoplasms (GEP-NEN) in Japan: a population-based study

BMC Cancer ◽  
2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Toshihiko Masui ◽  
◽  
Tetsuhide Ito ◽  
Izumi Komoto ◽  
Shinji Uemoto
Keyword(s):  
Cancer Registry ◽  
Population Data ◽  
Population Based ◽  
National Registry ◽  
Neuroendocrine Neoplasms ◽  
Population Based Study ◽  
National Cancer Registry ◽  
Exact Etiology ◽  
Using Data ◽  
Population Based Registry

Abstract Background The worldwide prevalence and incidence of neuroendocrine neoplasms (NEN) have been increasing recently, although few studies have analyzed data on the current situation of NENs in Japan. Here, the Japan Neuroendocrine Tumor Society (JNETS) planned to investigate the recent incidence and distribution of these tumors using data from the national cancer registry started in 2016. This study examined the incidence and distribution of primary sites as well as rate of advanced disease from this population-based registry. Methods A retrospective, population-based study using data from the national cancer registry in Japan (NCR) was conducted to evaluate patients with gastro-entero-pancreatic NEN (GEP-NEN) in 2016. Associated population data were used to determine annual age-adjusted incidences. Results A total of 6735 individuals were diagnosed with GEP-NEN in Japan in 2016. Annual onset incidence was 0.70/100,000 for pancreatic NEN and 2.84/100,000 for gastrointestinal NEN. NEN in the ileum accounted for only 1% of total GEP-NENs in Japan. Most NENs in the esophagus or lungs were neuroendocrine carcinomas (NECs), while the majority of those in the duodenum, ileum, appendix and rectum were grade 1 neuroendocrine tumors (NETs). Median age at initial diagnosis was in between 60 to 65. Tumors in the duodenum, appendix and rectum were mostly limited to local, while those in the esophagus, stomach and colon tended to show distant metastasis. In Japan, initial treatment for GEP-NENs was resection even if the tumor was NEC. Conclusions This is the first report of a national registry-based incidence and distribution of GEP-NEN in Japan. These data will serve as an important first step to determining the exact etiology and trends for this pathology in Japan.

scholarly journals Recent epidemiology of patients with Gastro-Entero-Pancreatic Neuroendocrine Neoplasms (GEP-NEN) in Japan: a population-based study

2020 ◽  
Author(s):  
Toshihiko Masui ◽  
Tetsuhide Ito ◽  
Izumi Komoto ◽  
Shinji Uemoto
Keyword(s):  
Cancer Registry ◽  
Population Data ◽  
Population Based ◽  
National Registry ◽  
Neuroendocrine Neoplasms ◽  
Population Based Study ◽  
National Cancer Registry ◽  
Exact Etiology ◽  
Using Data ◽  
Neuroendocrine Carcinomas

Abstract Background The worldwide prevalence and incidence of neuroendocrine neoplasms (NEN) have been increasing recently, although few studies have analyzed data on the current situation of NENs in Japan. Here, the Japan Neuroendocrine Tumor Society (JNETS) planned to investigate the recent incidence and distribution of these tumors using data from the national cancer registry started in 2016. This study examined the incidence and distribution of primary sites as well as disease progression from this population-based registry.Methods A retrospective, population-based study using data from the national cancer registry in Japan (NCR) was conducted to evaluate patients with gastro-entero-pancreatic NEN (GEP-NEN) in 2016. Associated population data were used to determine annual age-adjusted incidences.Results A total of 6735 individuals were diagnosed with GEP-NEN in Japan in 2016. Annual onset incidence was 0.70/100,000 for pancreatic NEN and 2.84/100,000 for gastrointestinal NEN. NEN in the ileum accounted for only 1% of total GEP-NENs in Japan. Most NENs in the esophagus or lungs were neuroendocrine carcinomas (NECs), while the majority of those in the duodenum, ileum, appendix and rectum were grade 1 neuroendocrine tumors (NETs). Median age at initial diagnosis was in between 60 to 65. Initial progression of the tumor was mostly limited to local for tumors in the duodenum, appendix and rectum, while those in the esophagus, stomach and colon tended to show distant metastasis. In Japan, initial treatment for GEP-NENs was resection even if the tumor was NEC.Conclusions This is the first report of a national registry-based incidence and distribution of GEP-NEN in Japan. These data will serve as an important first step to determining the exact etiology and trends for this pathology in Japan.

scholarly journals Development of a National Cancer Registry in a Low Resourced Country: The Case of Kenya National Cancer Registry Programme

2018 ◽  
Vol 4 (Supplement 2) ◽  
pp. 216s-216s
Author(s):  
A. Korir ◽  
R. Gakunga ◽  
N. Okerosi ◽  
A. Karagu ◽  
N. Buziba ◽  
...  
Keyword(s):  
Cancer Registry ◽  
Hpv Vaccination ◽  
Cancer Registries ◽  
Population Based ◽  
National Registry ◽  
Cancer Registration ◽  
National Cancer Registry ◽  
Background Population ◽  
Geographical Regions ◽  
Entire Country

Background: Population-based cancer registration represents the gold standard for the provision of information on cancer incidence in a defined population (Bray F, et. al, IARC Technical Report No. 43). In Kenya, the incidence and prevalence of cancer has not been well documented. The existing population-based cancer registries (PBCRs) cover less than 10% of Kenya's population. Kenya is made up of 47 administrative counties and has a population of over 45 million people. Aim: To establish a National Cancer Registry Program that will compile national data on incidence, mortality and trends of cancer in Kenya over time. Methods: Three functional PBCRs have been in existence covering 3 counties: Nairobi, Eldoret and Kisumu. Needs assessment was conducted in the 3 registries. Additional support and resources were provided. New registries were set up in different geographical regions of Kenya. A centralized office to host the national registry was established and equipped at the Centre for Clinical Research, Kenya Medical Research Institute. Sensitization and awareness activities targeting the leaders in the selected counties were undertaken. Similarly trainings and technical support of the regional registries were conducted. Data were collected on to case registration forms, coded using the International Classification of Diseases for Oncology (ICD-O); data entry, validation and analysis done using IARC software CanReg5. Results: Variations in cancer occurrence in the different counties were noted. However the leading cancers were somewhat similar in the 8 counties with prostate and esophageal cancers being the leading in men while breast and cervical cancer being top among women. These variations could provide understanding on causation of certain types of cancers. Data highlights the need to develop and expand intervention programs like HPV vaccination, screenings, early detection and early treatment. Governments' allocation of resources to cancer registries and surveillance programs is important as well as building partnerships. Conclusion: In countries with limited resources it is expensive to develop a national cancer registry covering the entire country. Our program demonstrates that a national cancer registry program can be established by setting up regional population-based cancer registries that covers a reasonable population of the entire country and aggregating the data in a centralized system. Population-based cancer registries are critical in generating data on burden of cancer in specified populations. These data should be used to inform effective cancer control programs and research.

Mass screening and age-specific incidence of neuroblastoma in Saitama Prefecture, Japan.

1995 ◽  
Vol 13 (8) ◽  
pp. 2033-2038 ◽  
Author(s):  
K Yamamoto ◽  
Y Hayashi ◽  
R Hanada ◽  
A Kikuchi ◽  
M Ichikawa ◽  
...  
Keyword(s):  
Incidence Rate ◽  
Mass Screening ◽  
Cancer Registry ◽  
Homovanillic Acid ◽  
Quantitative Measurement ◽  
Population Data ◽  
Population Based ◽  
National Registry ◽  
Qualitative Assessment ◽  
Vanillylmandelic Acid

PURPOSE To provide the population-based incidence rate of neuroblastoma and to determine the effect of mass screening on the annual age-specific incidence of the tumor in Saitama Prefecture, Japan, from 1981 to 1992. METHODS Data on screened infants and patients detected by the screening were obtained from the records of the Prefectural Screening Center. Data on neuroblastomas in this area were obtained from the Children's Cancer Registry of the Saitama Prefectural Government (Prefectural Registry) and from the Japan Children's Cancer Registry (National Registry). Population data were obtained from the Prefectural Census. Mass screening for 6-month-old infants was performed by qualitative assessment of urinary vanillylmandelic acid (VMA) from June 1981 to September 1989 and by quantitative measurement of VMA/creatinine (Cre) and homovanillic acid (HVA)/Cre from October 1989 to December 1992. RESULTS Between 1981 and 1992, 199 cases of neuroblastoma, which include 74 cases detected by mass screening, were identified in Saitama Prefecture. The incidence rate for children under 15 years of age increased from 6.4/10(6) to 20.1/10(6), that for children 0 to 4 years of age increased from 17.0/10(6) to 64.1/10(6), and that for infants under 1 year of age increased from 27.9/10(6) to 260.4/10(6) during these 12 years. No significant reduction in the incidence rate was observed for children over 1 year of age. CONCLUSION The incidence rate for children under 15 years of age increased with mass screening. The rate for infants was sharply increased, with no corresponding decrease in the rate for children at older ages. These data suggest that there is a subset of neuroblastoma that can be detected by mass screening at 6 months of age but would not be diagnosed later clinically.

scholarly journals Temporal trends in the proportion cured for cancer of the colon and rectum: A population-based study using data from the Finnish Cancer Registry

2007 ◽  
Vol 121 (9) ◽  
pp. 2052-2059 ◽  
Author(s):  
Paul C. Lambert ◽  
Paul W. Dickman ◽  
Pia Österlund ◽  
Therese Andersson ◽  
Risto Sankila ◽  
...  
Keyword(s):  
Cancer Registry ◽  
Temporal Trends ◽  
Population Based ◽  
Population Based Study ◽  
Colon And Rectum ◽  
Using Data

scholarly journals Lessons learned about appendiceal neuroendocrine neoplasms from data analysis of the Belgian Cancer Registry 2010-2015

2021 ◽  
Vol 84 (3) ◽  
Author(s):  
S Ribeiro ◽  
F De Maeyer ◽  
M De Man ◽  
S Carton ◽  
P.J. Cuyle ◽  
...  
Keyword(s):  
Cancer Registry ◽  
Population Based ◽  
Lessons Learned ◽  
Biological Behavior ◽  
Neuroendocrine Neoplasms ◽  
Malignant Neoplasms ◽  
Medical Procedures ◽  
Population Based Study ◽  
Number Of Patients ◽  
Insurance Database

Background and study aims : Appendiceal neuroendocrine neo-plasms (aNENs) are a diverse group of malignant neoplasms ofvarying biological behavior for which information about manage-ment and outcome is sparse, with the majority of available studiesbeing retrospective, including only a limited number of patients,and therefore not necessarily reflecting the reality in the community.In the present study clinical, epidemiological and pathological dataof appendiceal neuroendocrine neoplasms in Belgium is providedand compared with current literature. Methods : A population-based study was conducted by linkingdata of the Belgian Cancer Registry with medical procedures inthe Belgian Health Insurance database for patients diagnosed withaNEN between 2010 and 2015. Results : We found an aNEN incidence of 0.97/100.000 personyears in Belgium. Neuroendocrine carcinoma of the appendix arerare. Most appendiceal neuroendocrine tumors (aNETs) are smallG1 tumors. Positive lymph nodes are often found in tumors largerthan 2cm, especially aNET G2. Conclusion : A rapid uptake of changing classifications was seenin the community. However, systematic reporting of risk factorsfor small aNEN can still be improved and should be stimulated.In 9% of cases, reclassifications had to be made, pointing out thatin a retrospective analysis, original pathological reports should bechecked for specific parameters, before reliable conclusions can be drawn.

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