Lessons learned about appendiceal neuroendocrine neoplasms from data analysis of the Belgian Cancer Registry 2010-2015

Background and study aims : Appendiceal neuroendocrine neo-plasms (aNENs) are a diverse group of malignant neoplasms ofvarying biological behavior for which information about manage-ment and outcome is sparse, with the majority of available studiesbeing retrospective, including only a limited number of patients,and therefore not necessarily reflecting the reality in the community.In the present study clinical, epidemiological and pathological dataof appendiceal neuroendocrine neoplasms in Belgium is providedand compared with current literature. Methods : A population-based study was conducted by linkingdata of the Belgian Cancer Registry with medical procedures inthe Belgian Health Insurance database for patients diagnosed withaNEN between 2010 and 2015. Results : We found an aNEN incidence of 0.97/100.000 personyears in Belgium. Neuroendocrine carcinoma of the appendix arerare. Most appendiceal neuroendocrine tumors (aNETs) are smallG1 tumors. Positive lymph nodes are often found in tumors largerthan 2cm, especially aNET G2. Conclusion : A rapid uptake of changing classifications was seenin the community. However, systematic reporting of risk factorsfor small aNEN can still be improved and should be stimulated.In 9% of cases, reclassifications had to be made, pointing out thatin a retrospective analysis, original pathological reports should bechecked for specific parameters, before reliable conclusions can be drawn.

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Recent epidemiology of patients with Gastro-Entero-Pancreatic Neuroendocrine Neoplasms (GEP-NEN) in Japan: a population-based study

10.21203/rs.3.rs-18847/v2 ◽

2020 ◽

Author(s):

Toshihiko Masui ◽

Tetsuhide Ito ◽

Izumi Komoto ◽

Shinji Uemoto

Keyword(s):

Cancer Registry ◽

Population Data ◽

Population Based ◽

National Registry ◽

Neuroendocrine Neoplasms ◽

Population Based Study ◽

National Cancer Registry ◽

Exact Etiology ◽

Using Data ◽

Population Based Registry

Abstract Background: The worldwide prevalence and incidence of neuroendocrine neoplasms (NEN) have been increasing recently, although few studies have analyzed data on the current situation of NENs in Japan. Here, the Japan Neuroendocrine Tumor Society (JNETS) planned to investigate the recent incidence and distribution of these tumors using data from the national cancer registry started in 2016. This study examined the incidence and distribution of primary sites as well as disease progression from this population-based registry. Methods: A retrospective, population-based study using data from the national cancer registry in Japan (NCR) was conducted to evaluate patients with gastro-entero-pancreatic NEN (GEP-NEN) in 2016. Associated population data were used to determine annual age-adjusted incidences. Results: A total of 6735 individuals were diagnosed with GEP-NEN in Japan in 2016. Annual onset incidence was 0.70/100,000 for pancreatic NEN and 2.84/100,000 for gastrointestinal NEN. NEN in the ileum accounted for only 1% of total GEP-NENs in Japan. Most NENs in the esophagus or lungs were neuroendocrine carcinomas (NECs), while the majority of those in the duodenum, ileum, appendix and rectum were grade 1 neuroendocrine tumors (NETs). Median age at initial diagnosis was in between 60 to 65. Initial progression of the tumor was mostly limited to local for tumors in the duodenum, appendix and rectum, while those in the esophagus, stomach and colon tended to show distant metastasis. In Japan, initial treatment for GEP-NENs was resection even if the tumor was NEC.Conclusions: This is the first report of a national registry-based incidence and distribution of GEP-NEN in Japan. These data will serve as an important first step to determining the exact etiology and trends for this pathology in Japan.

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Recent epidemiology of patients with Gastro-Entero-Pancreatic Neuroendocrine Neoplasms (GEP-NEN) in Japan: a population-based study

10.21203/rs.3.rs-18847/v4 ◽

2020 ◽

Author(s):

Toshihiko Masui ◽

Tetsuhide Ito ◽

Izumi Komoto ◽

Shinji Uemoto ◽

project study group

Keyword(s):

Cancer Registry ◽

Population Data ◽

Population Based ◽

National Registry ◽

Neuroendocrine Neoplasms ◽

Population Based Study ◽

National Cancer Registry ◽

Exact Etiology ◽

Using Data ◽

Population Based Registry

Abstract Background: The worldwide prevalence and incidence of neuroendocrine neoplasms (NEN) have been increasing recently, although few studies have analyzed data on the current situation of NENs in Japan. Here, the Japan Neuroendocrine Tumor Society (JNETS) planned to investigate the recent incidence and distribution of these tumors using data from the national cancer registry started in 2016. This study examined the incidence and distribution of primary sites as well as rate of advanced disease from this population-based registry.Methods: A retrospective, population-based study using data from the national cancer registry in Japan (NCR) was conducted to evaluate patients with gastro-entero-pancreatic NEN (GEP-NEN) in 2016. Associated population data were used to determine annual age-adjusted incidences.Results: A total of 6735 individuals were diagnosed with GEP-NEN in Japan in 2016. Annual onset incidence was 0.70/100,000 for pancreatic NEN and 2.84/100,000 for gastrointestinal NEN. NEN in the ileum accounted for only 1% of total GEP-NENs in Japan. Most NENs in the esophagus or lungs were neuroendocrine carcinomas (NECs), while the majority of those in the duodenum, ileum, appendix and rectum were grade 1 neuroendocrine tumors (NETs). Median age at initial diagnosis was in between 60 to 65. Tumors in the duodenum, appendix and rectum were mostly limited to local, while those in the esophagus, stomach and colon tended to show distant metastasis. In Japan, initial treatment for GEP-NENs was resection even if the tumor was NEC.Conclusions: This is the first report of a national registry-based incidence and distribution of GEP-NEN in Japan. These data will serve as an important first step to determining the exact etiology and trends for this pathology in Japan.

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Recent epidemiology of patients with Gastro-Entero-Pancreatic Neuroendocrine Neoplasms (GEP-NEN) in Japan: a population-based study

10.21203/rs.3.rs-18847/v5 ◽

2020 ◽

Author(s):

Toshihiko Masui ◽

Tetsuhide Ito ◽

Izumi Komoto ◽

Shinji Uemoto ◽

project study group

Keyword(s):

Cancer Registry ◽

Population Data ◽

Population Based ◽

National Registry ◽

Neuroendocrine Neoplasms ◽

Population Based Study ◽

National Cancer Registry ◽

Exact Etiology ◽

Using Data ◽

Population Based Registry

Abstract Background: The worldwide prevalence and incidence of neuroendocrine neoplasms (NEN) have been increasing recently, although few studies have analyzed data on the current situation of NENs in Japan. Here, the Japan Neuroendocrine Tumor Society (JNETS) planned to investigate the recent incidence and distribution of these tumors using data from the national cancer registry started in 2016. This study examined the incidence and distribution of primary sites as well as rate of advanced disease from this population-based registry.Methods: A retrospective, population-based study using data from the national cancer registry in Japan (NCR) was conducted to evaluate patients with gastro-entero-pancreatic NEN (GEP-NEN) in 2016. Associated population data were used to determine annual age-adjusted incidences.Results: A total of 6735 individuals were diagnosed with GEP-NEN in Japan in 2016. Annual onset incidence was 0.70/100,000 for pancreatic NEN and 2.84/100,000 for gastrointestinal NEN. NEN in the ileum accounted for only 1% of total GEP-NENs in Japan. Most NENs in the esophagus or lungs were neuroendocrine carcinomas (NECs), while the majority of those in the duodenum, ileum, appendix and rectum were grade 1 neuroendocrine tumors (NETs). Median age at initial diagnosis was in between 60 to 65. Tumors in the duodenum, appendix and rectum were mostly limited to local, while those in the esophagus, stomach and colon tended to show distant metastasis. In Japan, initial treatment for GEP-NENs was resection even if the tumor was NEC.Conclusions: This is the first report of a national registry-based incidence and distribution of GEP-NEN in Japan. These data will serve as an important first step to determining the exact etiology and trends for this pathology in Japan.

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Recent epidemiology of patients with Gastro-Entero-Pancreatic Neuroendocrine Neoplasms (GEP-NEN) in Japan: a population-based study

10.21203/rs.3.rs-18847/v1 ◽

2020 ◽

Author(s):

Toshihiko Masui ◽

Tetsuhide Ito ◽

Izumi Komoto ◽

Shinji Uemoto

Keyword(s):

Cancer Registry ◽

Population Data ◽

Population Based ◽

National Registry ◽

Neuroendocrine Neoplasms ◽

Population Based Study ◽

National Cancer Registry ◽

Exact Etiology ◽

Using Data ◽

Neuroendocrine Carcinomas

Abstract Background The worldwide prevalence and incidence of neuroendocrine neoplasms (NEN) have been increasing recently, although few studies have analyzed data on the current situation of NENs in Japan. Here, the Japan Neuroendocrine Tumor Society (JNETS) planned to investigate the recent incidence and distribution of these tumors using data from the national cancer registry started in 2016. This study examined the incidence and distribution of primary sites as well as disease progression from this population-based registry.Methods A retrospective, population-based study using data from the national cancer registry in Japan (NCR) was conducted to evaluate patients with gastro-entero-pancreatic NEN (GEP-NEN) in 2016. Associated population data were used to determine annual age-adjusted incidences.Results A total of 6735 individuals were diagnosed with GEP-NEN in Japan in 2016. Annual onset incidence was 0.70/100,000 for pancreatic NEN and 2.84/100,000 for gastrointestinal NEN. NEN in the ileum accounted for only 1% of total GEP-NENs in Japan. Most NENs in the esophagus or lungs were neuroendocrine carcinomas (NECs), while the majority of those in the duodenum, ileum, appendix and rectum were grade 1 neuroendocrine tumors (NETs). Median age at initial diagnosis was in between 60 to 65. Initial progression of the tumor was mostly limited to local for tumors in the duodenum, appendix and rectum, while those in the esophagus, stomach and colon tended to show distant metastasis. In Japan, initial treatment for GEP-NENs was resection even if the tumor was NEC.Conclusions This is the first report of a national registry-based incidence and distribution of GEP-NEN in Japan. These data will serve as an important first step to determining the exact etiology and trends for this pathology in Japan.

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Recent epidemiology of patients with Gastro-Entero-Pancreatic Neuroendocrine Neoplasms (GEP-NEN) in Japan: a population-based study

10.21203/rs.3.rs-18847/v3 ◽

2020 ◽

Author(s):

Toshihiko Masui ◽

Tetsuhide Ito ◽

Izumi Komoto ◽

Shinji Uemoto

Keyword(s):

Cancer Registry ◽

Population Data ◽

Population Based ◽

National Registry ◽

Neuroendocrine Neoplasms ◽

Population Based Study ◽

National Cancer Registry ◽

Exact Etiology ◽

Using Data ◽

Population Based Registry

Abstract Background: The worldwide prevalence and incidence of neuroendocrine neoplasms (NEN) have been increasing recently, although few studies have analyzed data on the current situation of NENs in Japan. Here, the Japan Neuroendocrine Tumor Society (JNETS) planned to investigate the recent incidence and distribution of these tumors using data from the national cancer registry started in 2016. This study examined the incidence and distribution of primary sites as well as rate of advanced disease from this population-based registry. Methods: A retrospective, population-based study using data from the national cancer registry in Japan (NCR) was conducted to evaluate patients with gastro-entero-pancreatic NEN (GEP-NEN) in 2016. Associated population data were used to determine annual age-adjusted incidences. Results: A total of 6735 individuals were diagnosed with GEP-NEN in Japan in 2016. Annual onset incidence was 0.70/100,000 for pancreatic NEN and 2.84/100,000 for gastrointestinal NEN. NEN in the ileum accounted for only 1% of total GEP-NENs in Japan. Most NENs in the esophagus or lungs were neuroendocrine carcinomas (NECs), while the majority of those in the duodenum, ileum, appendix and rectum were grade 1 neuroendocrine tumors (NETs). Median age at initial diagnosis was in between 60 to 65. Tumors in the duodenum, appendix and rectum were mostly limited to local, while those in the esophagus, stomach and colon tended to show distant metastasis. In Japan, initial treatment for GEP-NENs was resection even if the tumor was NEC.Conclusions: This is the first report of a national registry-based incidence and distribution of GEP-NEN in Japan. These data will serve as an important first step to determining the exact etiology and trends for this pathology in Japan.

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Recent epidemiology of patients with Gastro-Entero-Pancreatic Neuroendocrine Neoplasms (GEP-NEN) in Japan: a population-based study

10.21203/rs.3.rs-18847/v6 ◽

2020 ◽

Author(s):

Toshihiko Masui ◽

Tetsuhide Ito ◽

Izumi Komoto ◽

Shinji Uemoto ◽

JNETS project study group

Keyword(s):

Cancer Registry ◽

Population Data ◽

Population Based ◽

National Registry ◽

Neuroendocrine Neoplasms ◽

Population Based Study ◽

National Cancer Registry ◽

Exact Etiology ◽

Using Data ◽

Population Based Registry

Abstract Background: The worldwide prevalence and incidence of neuroendocrine neoplasms (NEN) have been increasing recently, although few studies have analyzed data on the current situation of NENs in Japan. Here, the Japan Neuroendocrine Tumor Society (JNETS) planned to investigate the recent incidence and distribution of these tumors using data from the national cancer registry started in 2016. This study examined the incidence and distribution of primary sites as well as rate of advanced disease from this population-based registry.Methods: A retrospective, population-based study using data from the national cancer registry in Japan (NCR) was conducted to evaluate patients with gastro-entero-pancreatic NEN (GEP-NEN) in 2016. Associated population data were used to determine annual age-adjusted incidences.Results: A total of 6735 individuals were diagnosed with GEP-NEN in Japan in 2016. Annual onset incidence was 0.70/100,000 for pancreatic NEN and 2.84/100,000 for gastrointestinal NEN. NEN in the ileum accounted for only 1% of total GEP-NENs in Japan. Most NENs in the esophagus or lungs were neuroendocrine carcinomas (NECs), while the majority of those in the duodenum, ileum, appendix and rectum were grade 1 neuroendocrine tumors (NETs). Median age at initial diagnosis was in between 60 to 65. Tumors in the duodenum, appendix and rectum were mostly limited to local, while those in the esophagus, stomach and colon tended to show distant metastasis. In Japan, initial treatment for GEP-NENs was resection even if the tumor was NEC.Conclusions: This is the first report of a national registry-based incidence and distribution of GEP-NEN in Japan. These data will serve as an important first step to determining the exact etiology and trends for this pathology in Japan.

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Recent epidemiology of patients with gastro-entero-pancreatic neuroendocrine neoplasms (GEP-NEN) in Japan: a population-based study

BMC Cancer ◽

10.1186/s12885-020-07581-y ◽

2020 ◽

Vol 20 (1) ◽

Author(s):

Toshihiko Masui ◽

◽

Tetsuhide Ito ◽

Izumi Komoto ◽

Shinji Uemoto

Keyword(s):

Cancer Registry ◽

Population Data ◽

Population Based ◽

National Registry ◽

Neuroendocrine Neoplasms ◽

Population Based Study ◽

National Cancer Registry ◽

Exact Etiology ◽

Using Data ◽

Population Based Registry

Abstract Background The worldwide prevalence and incidence of neuroendocrine neoplasms (NEN) have been increasing recently, although few studies have analyzed data on the current situation of NENs in Japan. Here, the Japan Neuroendocrine Tumor Society (JNETS) planned to investigate the recent incidence and distribution of these tumors using data from the national cancer registry started in 2016. This study examined the incidence and distribution of primary sites as well as rate of advanced disease from this population-based registry. Methods A retrospective, population-based study using data from the national cancer registry in Japan (NCR) was conducted to evaluate patients with gastro-entero-pancreatic NEN (GEP-NEN) in 2016. Associated population data were used to determine annual age-adjusted incidences. Results A total of 6735 individuals were diagnosed with GEP-NEN in Japan in 2016. Annual onset incidence was 0.70/100,000 for pancreatic NEN and 2.84/100,000 for gastrointestinal NEN. NEN in the ileum accounted for only 1% of total GEP-NENs in Japan. Most NENs in the esophagus or lungs were neuroendocrine carcinomas (NECs), while the majority of those in the duodenum, ileum, appendix and rectum were grade 1 neuroendocrine tumors (NETs). Median age at initial diagnosis was in between 60 to 65. Tumors in the duodenum, appendix and rectum were mostly limited to local, while those in the esophagus, stomach and colon tended to show distant metastasis. In Japan, initial treatment for GEP-NENs was resection even if the tumor was NEC. Conclusions This is the first report of a national registry-based incidence and distribution of GEP-NEN in Japan. These data will serve as an important first step to determining the exact etiology and trends for this pathology in Japan.

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Time trends in treatment strategies and survival of older versus younger patients with synchronous metastasized melanoma – a population-based study in the Netherlands Cancer Registry

Journal of Geriatric Oncology ◽

10.1016/s1879-4068(21)00336-2 ◽

2021 ◽

Vol 12 (8) ◽

pp. S5

Author(s):

D. van der Ziel ◽

M. Derks ◽

E. Kapiteijn ◽

E. Bastiaannet ◽

M. Louwman ◽

...

Keyword(s):

The Netherlands ◽

Cancer Registry ◽

Time Trends ◽

Treatment Strategies ◽

Population Based ◽

Population Based Study ◽

Younger Patients ◽

Netherlands Cancer Registry

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Conditional Survival and Cure of Patients With Colon or Rectal Cancer: A Population-Based Study

Journal of the National Comprehensive Cancer Network ◽

10.6004/jnccn.2020.7568 ◽

2020 ◽

Vol 18 (9) ◽

pp. 1230-1237 ◽

Cited By ~ 1

Author(s):

Seyed M. Qaderi ◽

Paul W. Dickman ◽

Johannes H.W. de Wilt ◽

Rob H.A. Verhoeven

Keyword(s):

Rectal Cancer ◽

Colon Cancer ◽

Population Based ◽

Stage I ◽

Stage Iii ◽

Disease Stage ◽

Conditional Survival ◽

Population Based Study ◽

Pathologic Stage ◽

Number Of Patients

Background: The increasing number of colorectal cancer (CRC) survivors need survival estimates that account for the time already survived. The aim of this population-based study was to determine conditional survival, cure proportions, and time-to-cure (TTC) of patients with colon or rectal cancer. Materials and Methods: All patients with pathologic stage I–III CRC treated with endoscopy or surgery, diagnosed and registered in the Netherlands Cancer Registry between 1995 and 2016, and aged 18 to 99 years were included. Conditional survival was calculated for those diagnosed before and after 2007. Cure proportions were calculated using flexible parametric models. Results: A total of 175,384 patients with pathologic stage I (25%), II (38%), or III disease (37%) were included. Conditional 5-year survival of patients with stage I, II, and III colon cancer having survived 5 years was 98%, 94%, and 92%, respectively. For patients with stage I–III rectal cancer, this was 96%, 89%, and 85%, respectively. Statistical cure in patients with colon cancer was reached directly after diagnosis (stage I) to 6 years (stage III) after diagnosis depending on age, sex, and disease stage. Patients with rectal cancer reached cure 0.5 years after diagnosis (stage I) to 9 years after diagnosis (stage III). In 1995, approximately 42% to 46% of patients with stage III colon or rectal cancer, respectively, were considered cured, whereas in 2016 this percentage increased to 73% to 78%, respectively. Conclusions: The number of patients with CRC reaching cure has increased substantially over the years. This study’s results provide valuable insights into trends of CRC patient survival and are important for patients, clinicians, and policymakers.

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