Evaluation of the Risk Factors for Postoperative Neurocognitive Disorder in Elderly Patients Following Coronary Artery Bypass Grafting.

Abstract Background The incidence and risk factors of postoperative neurocognitive disorder (PND) following coronary artery bypass grafting (CABG) is still controversial. Exploring an effective and reliable predictor of PND is essential to the prevention of PND. This prospective observational study aimed to find the incidence rate as well as possible risk factors of PND in CABG.Methods Patients who underwent CABG were included. A battery of neuropsychological tests was performed preoperatively and 7 days after surgery. We used the Z score to analyze and comprehensively evaluate PND. The clinical characteristics of the patients were recorded. The levels of TNF-α, IL-1 (interleukin-1), IL-6 (interleukin-6), S100β, MDA (malondialdehyde) and T-AOC (total antioxidant capacity) were measured at different time points.Results A total of 82 patients were enrolled in the study. The incidence of PND was 25.6% 7 days after surgery. Patients were divided into the control group (N = 61) and the PND group (N = 21). The average age of patients in the PND group was 68.1 years, which was 64 years in the control group (P < 0.05). The average years of education in the PND group were significantly shorter than those in the control group (P < 0.05). The serum levels of IL-6, MDA, Il-1, and S100β in the PND group were significantly lower than those in the control group 1 day after surgery, and the T-AOC level was higher than that in the control group (P < 0.05) 1 day after surgery. The concentration of S100β in the PND group significantly higher than that in the control group 3 days after surgery (P < 0.05). Age, years of education, IL6, TAOC, MDA, IL1, and S100B were included in the multiple regression to search for risk factors of PND. The results showed that higher age (95%CI = 0.776–0.984, P = 0.026), lower years of education (95%CI = 1.006–1.736, P = 0.045) and higher MDA level (95%CI = 0.304–0.964, P = 0.037) were risk factors for PND.Conclusions Older age, lower educational level and higher MDA might be risk factors for PND 7 days after surgery. More researches in the future on this field needs to be conducted to prevent PND effectively and timely.Trail registration: The trail has been registered to the Chinese Clinical Trail Registry (ID: ChiCTR1800015606) on April 11, 2018.

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Mortality Risk Factors in Chronic Renal Failure Patients after Coronary Artery Bypass Grafting

Renal Failure ◽

10.1080/08860220701573525 ◽

2007 ◽

Vol 29 (7) ◽

pp. 823-828 ◽

Cited By ~ 5

Author(s):

Beril Akman ◽

Ayse Bilgic ◽

Gulsah Sasak ◽

Siren Sezer ◽

Atilla Sezgin ◽

...

Keyword(s):

Risk Factors ◽

Renal Failure ◽

Coronary Artery ◽

Chronic Renal Failure ◽

Coronary Artery Bypass Grafting ◽

Coronary Artery Bypass ◽

Mortality Risk ◽

Artery Bypass ◽

Bypass Grafting ◽

Artery Bypass Grafting

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Perioperative risk factors for new‐onset postoperative atrial fibrillation among patients after isolated coronary artery bypass grafting: A retrospective study

Journal of Advanced Nursing ◽

10.1111/jan.15045 ◽

2021 ◽

Author(s):

Hong‐Jae Choi ◽

Eun Ji Seo ◽

Jae‐Sung Choi ◽

Se Jin Oh ◽

Youn‐Jung Son

Keyword(s):

Risk Factors ◽

Atrial Fibrillation ◽

Retrospective Study ◽

Coronary Artery ◽

Coronary Artery Bypass Grafting ◽

Coronary Artery Bypass ◽

Artery Bypass ◽

Bypass Grafting ◽

Artery Bypass Grafting ◽

New Onset

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Clinical Effectiveness of Intravenous Exenatide Infusion in Perioperative Glycemic Control after Coronary Artery Bypass Graft Surgery

Anesthesiology ◽

10.1097/aln.0000000000001838 ◽

2017 ◽

Vol 127 (5) ◽

pp. 775-787 ◽

Cited By ~ 13

Author(s):

Guillaume Besch ◽

Andrea Perrotti ◽

Frederic Mauny ◽

Marc Puyraveau ◽

Maude Baltres ◽

...

Keyword(s):

Blood Glucose ◽

Coronary Artery ◽

Coronary Artery Bypass Grafting ◽

Coronary Artery Bypass ◽

Artery Bypass ◽

Blood Glucose Control ◽

Target Range ◽

Control Group ◽

Bypass Grafting ◽

Artery Bypass Grafting

Abstract Background We aimed to assess the clinical effectiveness of intravenous exenatide compared to insulin in perioperative blood glucose control in coronary artery bypass grafting surgery patients. Methods Patients more than 18 yr old admitted for elective coronary artery bypass grafting were included in a phase II/III nonblinded randomized superiority trial. Current insulin use and creatinine clearance of less than 60 ml/min were exclusion criteria. Two groups were compared: the exenatide group, receiving exenatide (1-h bolus of 0.05 µg/min followed by a constant infusion of 0.025 µg/min), and the control group, receiving insulin therapy. The blood glucose target range was 100 to 139 mg/dl. The primary outcome was the proportion of patients who spent at least 50% of the study period within the target range. The consumption of insulin (Cinsulin) and the time to start insulin (Tinsulin) were compared between the two groups. Results In total, 53 and 51 patients were included and analyzed in the exenatide and control groups, respectively (age: 70 ± 9 vs. 68 ± 11 yr; diabetes mellitus: 12 [23%] vs. 10 [20%]). The primary outcome was observed in 38 (72%) patients in the exenatide group and in 41 (80%) patients in the control group (odds ratio [95% CI] = 0.85 [0.34 to 2.11]; P = 0.30). Cinsulin was significantly lower (60 [40 to 80] vs. 92 [63 to 121] U, P < 0.001), and Tinsulin was significantly longer (12 [7 to 16] vs. 7 [5 to 10] h, P = 0.02) in the exenatide group. Conclusions Exenatide alone at the dose used was not enough to achieve adequate blood glucose control in coronary artery bypass grafting patients, but it reduces overall consumption of insulin and increases the time to initiation of insulin.

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Risk factors for the return of mitral regurgitation after coronary artery bypass grafting and mitral valve reconstruction in patients with ischemic cardiomyopathy

10.22541/au.161522486.60013565/v1 ◽

2021 ◽

Author(s):

Iuliia Kareva ◽

Vidadiue Efendiev ◽

Alexey Nesmachnyy ◽

Sardor Rakhmonov ◽

Alexander Chernyavskiy ◽

...

Keyword(s):

Risk Factors ◽

Coronary Artery ◽

Coronary Artery Bypass Grafting ◽

Mitral Valve ◽

Mitral Regurgitation ◽

Coronary Artery Bypass ◽

Artery Bypass ◽

Mitral Insufficiency ◽

Bypass Grafting ◽

Artery Bypass Grafting

Background and Aim: We aimed to identify risk factors for recurrent mitral regurgitation in two surgical treatment groups: isolated coronary artery bypass grafting (CABG) and CABG combined with mitral valve (MV) repair in patients with moderate ischemic mitral regurgitation (IMR). Methods: A single-centre, prospective, randomised study, which included 76 patients with ICM and moderate mitral regurgitation (MR). Study included two groups: isolated CABG and CABG with MV repair (MVR). Isolated annuloplasty was used to correct mitral insufficiency in the CABG + MVR group. Results: Isolated CABG or CABG combined with MVR in patients with ICM does not lead to a statistically significant decreasing of MR in the long-term period compared to baseline values. However, in one year after surgery, the degree of MR after combined surgery is lower than the initial values. The identification of predictors of the progression of IMR in ICM made it possible to determine the threshold values for the effectiveness of MVR, and the assessment of echocardiographic predictors for annuloplasty helps to choose the right surgical tactic of patients. Conclusions: Coronary revascularization with surgical of IMR in patients with ICM does not increase the number of complications in the early postoperative period compared to the group of isolated CABG. In patients with ICM and moderate MR after isolated CABG, the progression of MR (MR of the 3rd degree, initially 0%, after 12 months 31%, after 36 months 71%; p <0.001) was observed even with an initially moderate expansion of the fibrous ring of the MV.

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Risk factors of using intraoperative intraaortic balloon pumping in patients undergoing isolated off-pump coronary artery bypass grafting

Journal of the Japanese Coronary Association ◽

10.7793/jcoron.22.16-00015 ◽

2016 ◽

Vol 23 (1) ◽

pp. 12-16

Author(s):

Tatsuya Seki ◽

Toshihito Yoshida

Keyword(s):

Risk Factors ◽

Coronary Artery ◽

Coronary Artery Bypass Grafting ◽

Coronary Artery Bypass ◽

Artery Bypass ◽

Bypass Grafting ◽

Intraaortic Balloon ◽

Artery Bypass Grafting ◽

Off Pump ◽

Pump Coronary Artery Bypass

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Risk Factors for Late Stroke After Coronary Artery Bypass Grafting

ACC Current Journal Review ◽

10.1016/j.accreview.2005.11.077 ◽

2005 ◽

Vol 14 (12) ◽

pp. 48-49

Author(s):

T. Schachner ◽

A. Zimmer ◽

G. Nagele ◽

G. Laufer ◽

J. Bonatti

Keyword(s):

Risk Factors ◽

Coronary Artery ◽

Coronary Artery Bypass Grafting ◽

Coronary Artery Bypass ◽

Artery Bypass ◽

Bypass Grafting ◽

Artery Bypass Grafting

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Prevalence of leg wound complications after coronary artery bypass grafting: determination of risk factors

American Journal of Critical Care ◽

10.4037/ajcc1999.8.3.149 ◽

1999 ◽

Vol 8 (3) ◽

pp. 149-153 ◽

Cited By ~ 22

Author(s):

MA Goldsborough ◽

MH Miller ◽

J Gibson ◽

S Creighton-Kelly ◽

CA Custer ◽

...

Keyword(s):

Risk Factors ◽

Coronary Artery ◽

Coronary Artery Bypass Grafting ◽

Coronary Artery Bypass ◽

Artery Bypass ◽

Wound Complications ◽

Bypass Grafting ◽

Community Settings ◽

Artery Bypass Grafting

BACKGROUND: The reported prevalence of leg wound complications after coronary artery bypass grafting is 2% to 24%. Decreased length of hospital stay for patients who have this surgical procedure poses new care requirements in both acute care and community settings. OBJECTIVE: To determine the prevalence of postoperative leg wound complications in patients undergoing coronary artery bypass grafting and the risk factors associated with these complications. METHOD: In this prospective, observational study, 547 consecutive patients who had coronary artery bypass grafting alone or in combination with other cardiac surgical procedures were examined for evidence of leg wound complications each day after surgery during hospitalization. After discharge, problems were detected by home care nurses. RESULTS: The prevalence of leg wound complications was 6.8%. Factors significant by multiple logistic regression included preoperative hospitalization, use of an Ace elastic bandage in the operating room, the length of time the leg incision remained open in the operating room, and administration of nicardipine intravenously in the intensive care unit. Odds ratios were calculated for each variable. Premorbid factors such as diabetes or peripheral vascular disease were not predictive of complications. On average, most problems occurred on postoperative day 10, when many patients were at home. CONCLUSIONS: The results highlight the need to detect complications early, in both the hospital and the community settings. The determination of factors related to poor outcomes may assist clinicians in improving healthcare delivery.

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