Complete tumor response in a patient with locally advanced lung large cell neuroendocrine carcinoma treated with Sintilimab plus platinum-based chemotherapy: a case report

Abstract Background pulmonary large-cell neuroendocrine carcinoma (LCNEC) is a rare subset of lung cancer with a poor prognosis. As LCNEC is an uncommon malignancy, the optimal treatment for LCNEC has not been established. Case presentation : we report a case of a 66-year-old man diagnosed with unresectable, locally advanced LCNEC who presented a partial radiographic response to immunotherapy combined with chemotherapy. Salvage surgery was performed after 4 cycles of docetaxel and cisplatin (DP) regimen plus sintilimab, which is a highly selective, fully human antiprogrammed death-ligand 1 monoclonal antibody. Moreover, a pathologic analysis of the resected piece revealed the absence of residual viable tumor cells. Conclusion this case suggests that patients with locally advanced LCNEC may benefit from neoadjuvant chemo-immunotherapy, it is worthy for further study.

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Complete tumor response of a locally advanced lung large-cell neuroendocrine carcinoma after palliative thoracic radiotherapy and immunotherapy with nivolumab

Lung Cancer ◽

10.1016/j.lungcan.2018.12.006 ◽

2019 ◽

Vol 128 ◽

pp. 53-56 ◽

Cited By ~ 8

Author(s):

Charlotte Mauclet ◽

Fabrice Duplaquet ◽

Lionel Pirard ◽

Benoît Rondelet ◽

Michael Dupont ◽

...

Keyword(s):

Neuroendocrine Carcinoma ◽

Tumor Response ◽

Locally Advanced ◽

Large Cell ◽

Large Cell Neuroendocrine Carcinoma ◽

Thoracic Radiotherapy ◽

Complete Tumor

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Complete remission of combined pulmonary large cell neuroendocrine carcinoma: a case report

Journal of International Medical Research ◽

10.1177/03000605211055387 ◽

2021 ◽

Vol 49 (11) ◽

pp. 030006052110553

Author(s):

Jian Xu ◽

Qi Feng ◽

Yong Chen ◽

Xiu-lan Liu ◽

Ou Jiang

Keyword(s):

Complete Remission ◽

Maintenance Therapy ◽

Neuroendocrine Carcinoma ◽

Locally Advanced ◽

Large Cell ◽

Large Cell Neuroendocrine Carcinoma ◽

Chest Tightness ◽

Lung Cancers ◽

Concurrent Radiotherapy ◽

Platinum Based Chemotherapy

Pulmonary large cell neuroendocrine carcinoma (LCNEC), which accounts for approximately 1% of all lung cancers, is a rare and highly aggressive malignancy with a poor prognosis. Therefore, it is important to devise an effective treatment strategy. In the treatment of locally advanced complex LCNEC, it is unique to first administer radiotherapy combined with albumin-bound paclitaxel plus carboplatin, followed by durvalumab for immune maintenance treatment after concurrent radiotherapy and chemotherapy to achieve complete remission. We report a 54-year-old man who smoked and who felt chest tightness for 2 weeks and was diagnosed as having combined pulmonary LCNEC. For patients with locally advanced pulmonary LCNEC, chemoradiotherapy increases overall survival. After surgical resection and chemoradiotherapy, our patient achieved complete remission. Durvalumab was then started to consolidate the treatment. After six courses of immune maintenance therapy, the patient developed grade 2 immune-related pneumonitis and took prednisone orally until the symptoms resolved, and then reached complete remission again. The patient achieved complete remission, which was a challenge with this rare carcinoma, through albumin-bound paclitaxel plus platinum-based chemotherapy combined with radiotherapy and durvalumab for immune maintenance therapy. This approach may provide a treatment option for locally advanced combined pulmonary LCNEC.

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Immunohistochemical studies of pulmonary large cell neuroendocrine carcinoma: A possible association between staining patterns with neuroendocrine markers and tumor response to chemotherapy

Journal of Thoracic and Cardiovascular Surgery ◽

10.1016/j.jtcvs.2012.03.036 ◽

2013 ◽

Vol 145 (3) ◽

pp. 839-846 ◽

Cited By ~ 17

Author(s):

Yugo Tanaka ◽

Hiroyuki Ogawa ◽

Kazuya Uchino ◽

Chiho Ohbayashi ◽

Yoshimasa Maniwa ◽

...

Keyword(s):

Neuroendocrine Carcinoma ◽

Tumor Response ◽

Large Cell ◽

Large Cell Neuroendocrine Carcinoma ◽

Neuroendocrine Markers ◽

Response To Chemotherapy ◽

Immunohistochemical Studies

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Large Cell Neuroendocrine Carcinoma of the Cervix with Sequential Metastasis to Different Sites: A Case Report

Case Reports in Oncology ◽

10.1159/000493912 ◽

2018 ◽

Vol 11 (3) ◽

pp. 665-670

Author(s):

Eunhyun Lee ◽

Yong-Il Ji

Keyword(s):

Case Report ◽

Effective Treatment ◽

Neuroendocrine Carcinoma ◽

Radical Surgery ◽

Large Cell ◽

Chemoradiation Therapy ◽

Large Cell Neuroendocrine Carcinoma ◽

Adjuvant Chemoradiation ◽

Platinum Based Chemotherapy

Neuroendocrine carcinoma of the cervix is rare, and prognosis is very poor. Because of its rarity, effective treatment of neuroendocrine carcinoma of the cervix has not been established. It has distinct patterns of metastasis, but can be successfully treated with radical surgery and platinum-based chemotherapy. We report a 50-year-old woman who was diagnosed with large cell neuroendocrine carcinoma of the cervix and underwent radical surgery followed by adjuvant chemoradiation therapy. She experienced recurrence several times and to different sites, with sequential metastasis to the lung, breast, and retroperitoneum, but nevertheless survived more than 5 years.

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