Interplay of CREB and ATF2 in Ionizing Radiation-Induced Neuroendocrine Differentiation of Prostate Cancer Cells

2009 ◽  
Author(s):  
Chang-Deng Hu
Keyword(s):  
Prostate Cancer ◽  
Ionizing Radiation ◽  
Cancer Cells ◽  
Neuroendocrine Differentiation ◽  
Prostate Cancer Cells ◽  
Radiation Induced

scholarly journals Zerumbone Regulates DNA Repair Responding to Ionizing Radiation and Enhances Radiosensitivity of Human Prostatic Cancer Cells

2017 ◽  
Vol 17 (2) ◽  
pp. 292-298 ◽  
Author(s):  
Pai-Kai Chiang ◽  
Wei-Kung Tsai ◽  
Marcelo Chen ◽  
Wun-Rong Lin ◽  
Yung-Chiong Chow ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Dna Damage ◽  
Ionizing Radiation ◽  
Cancer Cells ◽  
Prostatic Cancer ◽  
Radiation Sensitivity ◽  
Human Prostate Cancer ◽  
Prostate Cancer Cells ◽  
Damage Repair ◽  
Radiation Induced

Introduction. Radiation therapy using ionizing radiation is widely used for the treatment of prostate cancer. The intrinsic radiation sensitivity of cancer cells could be enhanced by modulating multiple factors including the capacity to repair DNA damage, especially double-strand breaks (DSBs). We aimed to examine the effect of zerumbone on radiation sensitivity and its protective effects against ionizing radiation–induced DSB in human prostate cancer cells. Materials and Methods. The human prostate cancer PC3 and DU145 cell lines were used. A colony formation assay was performed to analyze the radiation survival of cells. DNA histogram and generation of reactive oxygen species (ROS) were examined using flow cytometry. Western blotting was used to examine the expression of regulatory molecules related to DNA damage repair. Results. Pretreatment with zerumbone enhanced the radiation effect on prostate cancer cells. Zerumbone delayed the abrogation of radiation-induced expression of γ-H2AX, an indicator of DNA DSB. Zerumbone pretreatment markedly reduced ionizing radiation–induced upregulated expression of phosphorylated ATM (ataxia telangiectasia-mutated), which was partially reversed by the ATM agonist methyl methanesulfonate. Ionizing radiation augmented and zerumbone pretreatment reduced the expression of Jak2 and Stat3, which are involved in DNA damage repair signaling. No significant effect on the generation of ROS and expression of ATR was noted after zerumbone treatment. Conclusion: Zerumbone sensitized DU145 and PC3 prostatic cancer cells to ionizing radiation by modulating radiation-induced ATM activation during repair of DNA DSBs.

scholarly journals Radiation-induced HIF-1α cell survival pathway is inhibited by soy isoflavones in prostate cancer cells

2009 ◽  
Vol 124 (7) ◽  
pp. 1675-1684 ◽  
Author(s):  
Vinita Singh-Gupta ◽  
Hao Zhang ◽  
Sanjeev Banerjee ◽  
Dejuan Kong ◽  
Julian J. Raffoul ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cell Survival ◽  
Cancer Cells ◽  
Soy Isoflavones ◽  
Prostate Cancer Cells ◽  
Survival Pathway ◽  
Radiation Induced

scholarly journals Overexpression of an α1H(Cav3.2) T-type Calcium Channel during Neuroendocrine Differentiation of Human Prostate Cancer Cells

2002 ◽  
Vol 277 (13) ◽  
pp. 10824-10833 ◽  
Author(s):  
Pascal Mariot ◽  
Karine Vanoverberghe ◽  
Nathalie Lalevée ◽  
Michel F. Rossier ◽  
Natalia Prevarskaya
Keyword(s):  
Prostate Cancer ◽  
Calcium Channel ◽  
Cancer Cells ◽  
Neuroendocrine Differentiation ◽  
Human Prostate ◽  
Human Prostate Cancer ◽  
Prostate Cancer Cells

scholarly journals Androgen Deprivation Followed by Acute Androgen Stimulation Selectively Sensitizes AR-Positive Prostate Cancer Cells to Ionizing Radiation

2016 ◽  
Vol 22 (13) ◽  
pp. 3310-3319 ◽  
Author(s):  
Mohammad Hedayati ◽  
Michael C. Haffner ◽  
Jonathan B. Coulter ◽  
Raju R. Raval ◽  
Yonggang Zhang ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Ionizing Radiation ◽  
Cancer Cells ◽  
Androgen Deprivation ◽  
Prostate Cancer Cells
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