Studies on the Metabolic Fate of Amrubicin Hydrochloride (SM-5887), a Novel Antitumor Agent. (II): Blood Concentration, Distribution, Metabolism and Excretion after Repeated Intravenous Administration to Rats.

Shunji NAKAI; Kyoko AKAO; Masaki ITO; Hiroshi KANAMARU; Iwao NAKATSUKA

doi:10.2133/dmpk.13.78

Studies on the Metabolic Fate of Amrubicin Hydrochloride (SM-5887), a Novel Antitumor Agent. (II): Blood Concentration, Distribution, Metabolism and Excretion after Repeated Intravenous Administration to Rats.

Drug Metabolism and Pharmacokinetics ◽

10.2133/dmpk.13.78 ◽

1998 ◽

Vol 13 (2) ◽

pp. 78-90

Author(s):

Shunji NAKAI ◽

Kyoko AKAO ◽

Masaki ITO ◽

Hiroshi KANAMARU ◽

Iwao NAKATSUKA

Keyword(s):

Intravenous Administration ◽

Blood Concentration ◽

Concentration Distribution ◽

Antitumor Agent ◽

Metabolic Fate

Download Full-text

Studies on the Metabolic Fate of Amrubicin Hydrochloride (SM-5887), a Novel Antitumor Agent. (I): Blood Concentration, Distribution, Metabolism and Excretion after a Single Intravenous Administration to Rats.

Drug Metabolism and Pharmacokinetics ◽

10.2133/dmpk.13.61 ◽

1998 ◽

Vol 13 (2) ◽

pp. 61-77 ◽

Cited By ~ 1

Author(s):

Shunji NAKAI ◽

Kyoko AKAO ◽

Masaki ITO ◽

Yoshiko MIZUNO ◽

Setsuko KOMURO ◽

...

Keyword(s):

Intravenous Administration ◽

Blood Concentration ◽

Concentration Distribution ◽

Antitumor Agent ◽

Metabolic Fate ◽

Single Intravenous Administration

Download Full-text

Studies on the Metabolic Fate of Amrubicin Hydrochloride (SM-5887), a Novel Antitumor Agent. (III): Blood Concentration, Distribution, Metabolism and Excretion after a Single Intravenous Administration to Dogs.

Drug Metabolism and Pharmacokinetics ◽

10.2133/dmpk.13.91 ◽

1998 ◽

Vol 13 (2) ◽

pp. 91-99

Author(s):

Shunji NAKAI ◽

Kyoko AKAO ◽

Masaki ITO ◽

Setsuko KOMURO ◽

Hiroshi KANAMARU ◽

...

Keyword(s):

Intravenous Administration ◽

Blood Concentration ◽

Concentration Distribution ◽

Antitumor Agent ◽

Metabolic Fate ◽

Single Intravenous Administration

Download Full-text

Metabolic Fate of NKH477. (2). Blood Concentration, Distribution, Excretion and Effects on Drug-Metabolizing Enzyme System in Rats after Repeated Intravenous Administration.

Drug Metabolism and Pharmacokinetics ◽

10.2133/dmpk.13.221 ◽

1998 ◽

Vol 13 (3) ◽

pp. 221-228

Author(s):

Shin-ichi MATSUMOTO ◽

Tsuyoshi IRIE ◽

Toshiko EKI ◽

Kouwa YAMASHITA ◽

Hideaki SEKI ◽

...

Keyword(s):

Intravenous Administration ◽

Blood Concentration ◽

Concentration Distribution ◽

Enzyme System ◽

Metabolic Fate ◽

Drug Metabolizing Enzyme ◽

Metabolizing Enzyme

Download Full-text

Metabolic Fate of YM866, a Novel Fibrinolytic Agent (II). Plasma Concentration, Distribution, Metabolism and Excretion in Rats after Repeated Intravenous Administration.

Drug Metabolism and Pharmacokinetics ◽

10.2133/dmpk.11.11 ◽

1996 ◽

Vol 11 (1) ◽

pp. 11-29

Author(s):

Keishi OIKAWA ◽

Hidetaka KAMIMURA ◽

Takashi WATANABE ◽

Saburo HIGUCHI ◽

Satoshi KUROSAWA ◽

...

Keyword(s):

Plasma Concentration ◽

Intravenous Administration ◽

Concentration Distribution ◽

Metabolic Fate ◽

Fibrinolytic Agent

Download Full-text

Metabolic fate of recombinant human tissue plasminogen activator(rt-PA). (1): Blood or plasma concentration, distribution, metabolism and excretion in rats after single intravenous administration.

Drug Metabolism and Pharmacokinetics ◽

10.2133/dmpk.3.309 ◽

1988 ◽

Vol 3 (3) ◽

pp. 309-329 ◽

Cited By ~ 1

Author(s):

Seiu IIDA ◽

Masato IWAMOTO ◽

Masayuki SUZUKI ◽

Noriko HISANAGA ◽

Naoki TSUJII ◽

...

Keyword(s):

Plasma Concentration ◽

Plasminogen Activator ◽

Tissue Plasminogen Activator ◽

Intravenous Administration ◽

Human Tissue ◽

Concentration Distribution ◽

Metabolic Fate ◽

Tissue Plasminogen ◽

Single Intravenous Administration

Download Full-text

Metabolic Fate of a Novel Antiulcer Agent, T-593. (III). Blood Concentration, Distribution, Metabolism, Excretion and Effects on Hepatic Drug Metabolizing Enzyme System after Repeated Oral Administration to Rats.

Drug Metabolism and Pharmacokinetics ◽

10.2133/dmpk.13.459 ◽

1998 ◽

Vol 13 (5) ◽

pp. 459-471

Author(s):

Makoto ONODA ◽

Takumi KADOTA ◽

Shinsuke OOYAMA ◽

Hiroko MATSUTANI ◽

Hiroshi SAKAI ◽

...

Keyword(s):

Oral Administration ◽

Blood Concentration ◽

Concentration Distribution ◽

Enzyme System ◽

Metabolic Fate ◽

Hepatic Drug ◽

Drug Metabolizing Enzyme ◽

Antiulcer Agent ◽

Metabolizing Enzyme

Download Full-text

Metabolic Fate of 4-amino-1-hydroxybutylidene-1,1-bisphosphonate(alendronate). (II). Plasma Concentration, Distribution and Excretion after Repeated Intravenous Administration to 7-week Old Rats and after Single Intravenous Administration to 30-week Old Rats, and Transfer into the Fetus and Milk in Rats.

Drug Metabolism and Pharmacokinetics ◽

10.2133/dmpk.10.174 ◽

1995 ◽

Vol 10 (2) ◽

pp. 174-189 ◽

Cited By ~ 3

Author(s):

Tsutomu MOCHIZUKI ◽

Shin-ichi NISHIMURA ◽

Koichiro OKABE ◽

Yoshiaki AZUMA ◽

Shin UMEDA ◽

...

Keyword(s):

Plasma Concentration ◽

Intravenous Administration ◽

Concentration Distribution ◽

Metabolic Fate ◽

Old Rats ◽

Single Intravenous Administration

Download Full-text

Studies on the Metabolic Fate of Modified Recombinant Tissu-Type Plasminogen Activator (E6010) (2): Blood or Plasma Concentration, Distribution, Metabolism and Excretion in Rats after Repeated Intravenous Administration of 125I-E6010.

Drug Metabolism and Pharmacokinetics ◽

10.2133/dmpk.11.585 ◽

1996 ◽

Vol 11 (6) ◽

pp. 585-598

Author(s):

Hitoshi Mizuo ◽

Kiyomi KIKUCHI ◽

Mannen MISHIMA ◽

Masataka UEDA ◽

Teruaki YUZURIHA

Keyword(s):

Plasma Concentration ◽

Plasminogen Activator ◽

Intravenous Administration ◽

Concentration Distribution ◽

Metabolic Fate ◽

Type Plasminogen Activator

Download Full-text

Studies on the Metabolic Fate of M17055, a Novel Diuretic. (3): Plasma Concentration, Distribution and Excretion of Radioactivity in Male Rats after Repeated Daily Intravenous Administration of [14C]M17055.

Drug Metabolism and Pharmacokinetics ◽

10.2133/dmpk.16.325 ◽

2001 ◽

Vol 16 (4) ◽

pp. 325-332

Author(s):

Hiroyuki NAKAJIMA ◽

Takeshi NAKANISHI ◽

Hiroyasu NABA ◽

Keiichi IDA ◽

Nobuo OHZAWA

Keyword(s):

Plasma Concentration ◽

Intravenous Administration ◽

Concentration Distribution ◽

Male Rats ◽

Metabolic Fate

Download Full-text

Metabolic Fate of 4-amino-1-hydroxybutylidene-1,1-bisphosphonate(alendronate). (III). Plasma Concentration, Distribution in Bone and Excretion after Intravenous Administration to Beagle Dogs.

Drug Metabolism and Pharmacokinetics ◽

10.2133/dmpk.10.190 ◽

1995 ◽

Vol 10 (2) ◽

pp. 190-196

Author(s):

Tsutomu MOCHIZUKI ◽

Koichiro OKABE ◽

Shin UMEDA ◽

Satoshi KUDOH ◽

Noriko HARAKAWA ◽

...

Keyword(s):

Plasma Concentration ◽

Intravenous Administration ◽

Concentration Distribution ◽

Beagle Dogs ◽

Metabolic Fate

Download Full-text