Pharmacological Management of Acute Spinal Cord Injury: Overlooked Opportunities to Enhance Long-Term Neurological Function

2019 ◽  
Author(s):  
Catherine Jutzeler ◽  
Bobo Tong ◽  
Eric Bailey ◽  
Noam Y. Harel ◽  
Fred Geisler ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Neurological Function ◽  
Acute Spinal Cord Injury ◽  
Pharmacological Management ◽  
Cord Injury

scholarly journals Role of methyleprednisolone succinate in the management of acute spinal cord injury

1970 ◽  
Vol 9 (3) ◽  
pp. 168-172
Author(s):  
NK Karn ◽  
BP Shrestha ◽  
GP Khanal ◽  
R Rijal ◽  
P Chaudhary ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Neurological Status ◽  
Acute Spinal Cord Injury ◽  
Cord Injury ◽  
And Gender ◽  
One Year

Objective: To see the role of methyleprednisolone succinate in the management of acute spinal cord injury. Methods: A randomized control trial was done including the patients with acute spinal cord injury. They were divided into age and gender matched two groups. Patients with presence of active infection, associated open fracture, those on long term steroid and those who did not give consent to participate in the trial were excluded. One group received methyleprednisolone succinate within 8 hours of injury and another group did not receive the drug. Both the groups were managed nonoperatively. The neurological status of the patients was assessed at presentation, once spinal shock was over, at 6th week and 6th month and after one year according to ASIA scoring. Frankel grading was also assessed in every follow up. Conclusion: Methylprednisolone succinct prevents secondary cord injury to a great extent and hence its administration within 8 hours of injury results in a better functional (motor and sensory) outcome. Keywords: acute spinal cord injury; methyleprednisolone succinate DOI: http://dx.doi.org/10.3126/hren.v9i3.5585   HR 2011; 9(3): 168-172

Early Administration of l-Arginine in Experimental Acute Spinal Cord Injury Impairs Long-Term Motor Function Recovery

2011 ◽  
Vol 70 (5) ◽  
pp. 1198-1202 ◽  
Author(s):  
Abdieel Esquivel-Aguilar ◽  
Gilberto Castañeda-Hernández ◽  
Angelina Martínez-Cruz ◽  
Rebecca E. Franco-Bourland ◽  
Ignacio Madrazo ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Motor Function ◽  
Acute Spinal Cord Injury ◽  
Early Administration ◽  
Function Recovery ◽  
Cord Injury

scholarly journals Journal Club: Long-term functional outcome in patients with acquired infections after acute spinal cord injury

Neurology ◽  
2017 ◽  
Vol 89 (7) ◽  
pp. e76-e78 ◽  
Author(s):  
Freda M. Warner ◽  
Bobo Tong ◽  
Catherine R. Jutzeler ◽  
Jacquelyn J. Cragg ◽  
Paulina S. Scheuren ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Functional Outcome ◽  
Journal Club ◽  
Acute Spinal Cord Injury ◽  
Cord Injury

scholarly journals Urological Sequelae to Acute Spinal Cord Injury in Pet Dogs: A Natural Disease Model of Neuropathic Bladder Dysfunction

2019 ◽  
Vol 25 (3) ◽  
pp. 205-213
Author(s):  
Laurie Cook ◽  
Julie Byron ◽  
Sarah Moore
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Disease Model ◽  
Acute Spinal Cord Injury ◽  
Cost Of Treatment ◽  
Urine Retention ◽  
Cord Injury ◽  
Disc Extrusion

The authors review urologic dysfunction, including urine retention, incontinence, and recurrent and resistant urinary tract infection, in dogs as a sequela to acute spinal cord injury. Urologic sequelae to acute spinal cord injury (SCI) pose significant complications in human and canine patients impacting quality of life and long-term cost of treatment. Dogs with intervertebral disc extrusion may serve as a natural disease model of acute SCI for investigating translational interventions, both prophylactic and therapeutic, for urologic dysfunction in human SCI patients.

scholarly journals Meglumine cyclic adenylate improves neurological function following acute spinal cord injury in rats

2014 ◽  
Vol 10 (3) ◽  
pp. 1225-1230 ◽  
Author(s):  
JINGWU LIAO ◽  
JINGMING XIE ◽  
DAQIANG LIN ◽  
NING LU ◽  
LIMIN GUO ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Neurological Function ◽  
Acute Spinal Cord Injury ◽  
Cord Injury
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