scholarly journals Multicomponent Analysis in Head and Neck Squamous Cancer: Based on Genome, Epigenome and Transcriptome

2020 ◽  
Author(s):  
Ming Wei ◽  
Jinyang Zheng ◽  
Xun Chen ◽  
Guancheng Liu ◽  
Gangcai Zhu ◽  
...  
Keyword(s):  
Head And Neck ◽  
Multicomponent Analysis ◽  
Squamous Cancer

scholarly journals CCTs as new biomarkers for the prognosis of head and neck squamous cancer

Open Medicine ◽  
2020 ◽  
Vol 15 (1) ◽  
pp. 672-688
Author(s):  
Yanbo Dong ◽  
Siyu Lu ◽  
Zhenxiao Wang ◽  
Liangfa Liu
Keyword(s):  
Head And Neck ◽  
Survival Data ◽  
Enrichment Analysis ◽  
Functional Enrichment Analysis ◽  
Functional Enrichment ◽  
Advanced Tumor Stage ◽  
Expression Levels ◽  
T Complex ◽  
Advanced Tumor ◽  
Squamous Cancer

AbstractThe chaperonin-containing T-complex protein 1 (CCT) subunits participate in diverse diseases. However, little is known about their expression and prognostic values in human head and neck squamous cancer (HNSC). This article aims to evaluate the effects of CCT subunits regarding their prognostic values for HNSC. We mined the transcriptional and survival data of CCTs in HNSC patients from online databases. A protein–protein interaction network was constructed and a functional enrichment analysis of target genes was performed. We observed that the mRNA expression levels of CCT1/2/3/4/5/6/7/8 were higher in HNSC tissues than in normal tissues. Survival analysis revealed that the high mRNA transcriptional levels of CCT3/4/5/6/7/8 were associated with a low overall survival. The expression levels of CCT4/7 were correlated with advanced tumor stage. And the overexpression of CCT4 was associated with higher N stage of patients. Validation of CCTs’ differential expression and prognostic values was achieved by the Human Protein Atlas and GEO datasets. Mechanistic exploration of CCT subunits by the functional enrichment analysis suggests that these genes may influence the HNSC prognosis by regulating PI3K-Akt and other pathways. This study implies that CCT3/4/6/7/8 are promising biomarkers for the prognosis of HNSC.

Immunological network analysis in HPV associated head and neck squamous cancer and implications for disease prognosis

2018 ◽  
Vol 96 ◽  
pp. 28-36 ◽  
Author(s):  
Xiaohang Chen ◽  
Bingqing Yan ◽  
Huihuang Lou ◽  
Zhenji Shen ◽  
Fangjia Tong ◽  
...  
Keyword(s):  
Network Analysis ◽  
Head And Neck ◽  
Disease Prognosis ◽  
Squamous Cancer

scholarly journals Clinical data analysis reveals the role of OGR1 (GPR68) in head and neck squamous cancer

2020 ◽  
Vol 3 (1) ◽  
pp. 55-61 ◽  
Author(s):  
Wenlong Zhang ◽  
Yong Han ◽  
Weisha Li ◽  
Lin Cao ◽  
Libo Yan ◽  
...  
Keyword(s):  
Data Analysis ◽  
Head And Neck ◽  
Clinical Data ◽  
Clinical Data Analysis ◽  
Squamous Cancer

FGFR-mediated reactivation of ERK signaling contributes to insensitivity of head and neck squamous cancer to MEK inhibition

2016 ◽  
Vol 69 ◽  
pp. S129
Author(s):  
Y.J. Yang ◽  
H.J. Na ◽  
M.J. Ban ◽  
H.K. Byeon ◽  
Y.W. Koh ◽  
...  
Keyword(s):  
Head And Neck ◽  
Erk Signaling ◽  
Mek Inhibition ◽  
Squamous Cancer

Interleukins 7 and 12 are expressed in head and neck squamous cancer

2001 ◽  
Vol 26 (4) ◽  
pp. 302-306 ◽  
Author(s):  
V. Paleri ◽  
A. Pulimood ◽  
G.R. Davies ◽  
M.A. Birchall
Keyword(s):  
Head And Neck ◽  
Squamous Cancer

scholarly journals Human rhomboid family‐1 gene RHBDF1 participates in GPCR‐mediated transactivation of EGFR growth signals in head and neck squamous cancer cells

2008 ◽  
Vol 23 (2) ◽  
pp. 425-432 ◽  
Author(s):  
Huafei Zou ◽  
Sufi M. Thomas ◽  
Zhen‐Wen Yan ◽  
Jennifer R. Grandis ◽  
Andreas Vogt ◽  
...  
Keyword(s):  
Head And Neck ◽  
Cancer Cells ◽  
Squamous Cancer

scholarly journals Head and neck squamous cancer progression is marked by CLIC4 attenuation in tumor epithelium and reciprocal stromal upregulation of miR-142-3p, a novel post-transcriptional regulator of CLIC4

Oncotarget ◽  
2019 ◽  
Vol 10 (68) ◽  
pp. 7251-7275 ◽  
Author(s):  
Brandi L. Carofino ◽  
Kayla M. Dinshaw ◽  
Pui Yan Ho ◽  
Christophe Cataisson ◽  
Aleksandra M. Michalowski ◽  
...  
Keyword(s):  
Head And Neck ◽  
Cancer Progression ◽  
Transcriptional Regulator ◽  
Squamous Cancer
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