Continuously High Detection Sensitivity of Saliva, Viral Shedding in Salivary Glands and High Viral Load in Patients with COVID-19

Author(s):  
Fan Zhong ◽  
Yu-jie Liang ◽  
Jia-bin Xu ◽  
Mei Chu ◽  
Guo-fang Tang ◽  
...  
2020 ◽  
Author(s):  
Junliang Chen ◽  
Yanning Dai ◽  
Shuo Gao

Gait is closely associated with many chronic diseases. With the development of the Internet of Health Things (IoHT), long-term gait monitoring and corresponding analysis can be performed remotely, reducing a patient’s time and traffic cost, while providing doctors more valuable gait information. The presented work provides a feasible means for real-time, long-term, and accurate gait monitoring in an IoHT scenario. Through the experimental results, the high detection sensitivity of 54 mN and responsivity of 163 mV/N are achieved, thereby satisfying the need for analyzing various diseases. Furthermore, 16 hours continuous working time indicates its successful utilization during long-term gait monitoring.


2019 ◽  
Vol 43 (13) ◽  
pp. 5011-5019 ◽  
Author(s):  
Qinping Qiang ◽  
Yuhua Wang

In this study, to explore new phosphors for temperature sensing with high detection sensitivity, Yb3+/Ho3+/Mn2+ doped hexagonal NaGdF4 nanoparticles were designed.


2018 ◽  
Vol 12 (1) ◽  
pp. 4-14
Author(s):  
Kiyoshi Matsumoto ◽  
Isao Shimoyama ◽  
◽  

We have engaged in researching and developing a large number of sensor devices using piezo-resistive cantilevers. The important technical features of our sensor devices lie in their very high detection sensitivity that has been achieved by the use of cantilevers of a very thin structure: as a typical example, force-detection sensitivity of about 10 pN has been achieved by using cantilevers of 300-nm thickness. This paper presents our developed sensor devices and applications and their respective features: more specifically, devices to directly measure object-contacting forces, devices embedded in an elastic body to measure its deformations, devices to measure air flows and vibrations, devices to measure differential air pressure, devices to measure differential pressure between cavities and external environment, and devices with cantilevers arranged on the liquid interface.


Author(s):  
Ying Shen ◽  
Keith L. Mclaughlin ◽  
Junqi Gao ◽  
David Gray ◽  
Davresh Hasanyan ◽  
...  

2018 ◽  
Vol 6 (23) ◽  
pp. 3969-3978 ◽  
Author(s):  
Bin Luo ◽  
Xiaoxi Zhou ◽  
Peipei Jiang ◽  
Qiangying Yi ◽  
Fang Lan ◽  
...  

A novel polymer brush-functionalized magnetic composite nanosphere was successfully prepared, exhibiting large enrichment capacity, extremely high detection sensitivity, and high enrichment recovery in phosphorylated biomolecule enrichment.


Author(s):  
Ashish Goyal ◽  
Daniel B Reeves ◽  
E. Fabian Cardozo-Ojeda ◽  
Joshua T Schiffer ◽  
Bryan T. Mayer

SARS-CoV-2 is difficult to contain because many transmissions occur during the pre-symptomatic phase of infection. Moreover, in contrast to influenza, while most SARS-CoV-2 infected people do not transmit the virus to anybody, a small percentage secondarily infect large numbers of people. We designed mathematical models of SARS-CoV-2 and influenza which link observed viral shedding patterns with key epidemiologic features of each virus, including distributions of the number of secondary cases attributed to each infected person (individual R0) and the duration between symptom onset in the transmitter and secondarily infected person (serial interval). We identify that people with SARS-CoV-2 or influenza infections are usually contagious for fewer than one day congruent with peak viral load several days after infection, and that transmission is unlikely below a certain viral load. SARS-CoV-2 super-spreader events with over 10 secondary infections occur when an infected person is briefly shedding at a very high viral load and has a high concurrent number of exposed contacts. The higher predisposition of SARS-CoV-2 towards super-spreading events is not due to its 1-2 additional weeks of viral shedding relative to influenza. Rather, a person infected with SARS-CoV-2 exposes more people within equivalent physical contact networks than a person infected with influenza, likely due to aerosolization of virus. Our results support policies that limit crowd size in indoor spaces and provide viral load benchmarks for infection control and therapeutic interventions intended to prevent secondary transmission.


OSA Continuum ◽  
2020 ◽  
Vol 3 (5) ◽  
pp. 1274
Author(s):  
Keren Shemer ◽  
Gil Bashan ◽  
H. Hagai Diamandi ◽  
Yosef London ◽  
Tzur Raanan ◽  
...  

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