Optimization of CNN Model With Hyper Parameter Tuning for Enhancing Sturdiness in Classification of Histopathological Images

AbstractDiagnosis of different breast cancer stages using histopathology whole slide images is the gold standard in grading the tissue metastasis. Traditional diagnosis involves labor intensive procedures and is prone to human errors. Computer aided diagnosis assists medical experts as a second opinion tool in early detection which prevents further proliferation. Computing facilities have emerged to an extent where algorithms can attain near human accuracy in prediction of diseases, offering better treatment to curb further proliferation. The work introduced in the paper provides an interface in mobile platform, which enables the user to input histopathology image and obtain the prediction results with its class probability through embedded web-server. The trained deep convolutional neural networks model is deployed into a microcomputer-based embedded system after hyper-parameter tuning, offering congruent performance. The implementation results show that the embedded platform with custom-trained CNN model is suitable for medical image classification, as it takes less execution time and mean prediction time. It is also noticed that customized CNN classifier model outperforms pre-trained models when used in embedded platforms for prediction and classification of histopathology images. This work also emphasizes the relevance of portable and flexible embedded device in real time clinical applications.

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A Study on Multi Class Classification from Breast Cancer Images using Ensemble Network and Transfer Learning

Recent Patents on Engineering ◽

10.2174/1872212114999201109205421 ◽

2020 ◽

Vol 14 ◽

Author(s):

Lahari Tipirneni ◽

Rizwan Patan

Keyword(s):

Breast Cancer ◽

Neural Network ◽

Convolutional Neural Network ◽

Binary Classification ◽

Disease Diagnosis ◽

Feature Descriptors ◽

Histopathological Images ◽

Viable Approach ◽

Multi Class Classification

Abstract:: Millions of deaths all over the world are caused by breast cancer every year. It has become the most common type of cancer in women. Early detection will help in better prognosis and increases the chance of survival. Automating the classification using Computer-Aided Diagnosis (CAD) systems can make the diagnosis less prone to errors. Multi class classification and Binary classification of breast cancer is a challenging problem. Convolutional neural network architectures extract specific feature descriptors from images, which cannot represent different types of breast cancer. This leads to false positives in classification, which is undesirable in disease diagnosis. The current paper presents an ensemble Convolutional neural network for multi class classification and Binary classification of breast cancer. The feature descriptors from each network are combined to produce the final classification. In this paper, histopathological images are taken from publicly available BreakHis dataset and classified between 8 classes. The proposed ensemble model can perform better when compared to the methods proposed in the literature. The results showed that the proposed model could be a viable approach for breast cancer classification.

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Time-frequency time-space long short-term memory networks for image classification of histopathological tissue

Scientific Reports ◽

10.1038/s41598-021-93160-5 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Tuan D. Pham

Keyword(s):

Image Analysis ◽

Short Term Memory ◽

Disease Diagnosis ◽

Short Term ◽

Term Memory ◽

Time Frequency ◽

Time Space ◽

Histopathological Images ◽

Long Short Term Memory

AbstractImage analysis in histopathology provides insights into the microscopic examination of tissue for disease diagnosis, prognosis, and biomarker discovery. Particularly for cancer research, precise classification of histopathological images is the ultimate objective of the image analysis. Here, the time-frequency time-space long short-term memory network (TF-TS LSTM) developed for classification of time series is applied for classifying histopathological images. The deep learning is empowered by the use of sequential time-frequency and time-space features extracted from the images. Furthermore, unlike conventional classification practice, a strategy for class modeling is designed to leverage the learning power of the TF-TS LSTM. Tests on several datasets of histopathological images of haematoxylin-and-eosin and immunohistochemistry stains demonstrate the strong capability of the artificial intelligence (AI)-based approach for producing very accurate classification results. The proposed approach has the potential to be an AI tool for robust classification of histopathological images.

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Deep Learning for the Classification of Non-Hodgkin Lymphoma on Histopathological Images

Cancers ◽

10.3390/cancers13102419 ◽

2021 ◽

Vol 13 (10) ◽

pp. 2419

Author(s):

Georg Steinbuss ◽

Mark Kriegsmann ◽

Christiane Zgorzelski ◽

Alexander Brobeil ◽

Benjamin Goeppert ◽

...

Keyword(s):

Deep Learning ◽

Hodgkin Lymphoma ◽

Expert Knowledge ◽

B Cell Lymphoma ◽

High Accuracy ◽

Lymphocytic Leukemia ◽

Non Hodgkin Lymphoma ◽

Image Patches ◽

Histopathological Images

The diagnosis and the subtyping of non-Hodgkin lymphoma (NHL) are challenging and require expert knowledge, great experience, thorough morphological analysis, and often additional expensive immunohistological and molecular methods. As these requirements are not always available, supplemental methods supporting morphological-based decision making and potentially entity subtyping are required. Deep learning methods have been shown to classify histopathological images with high accuracy, but data on NHL subtyping are limited. After annotation of histopathological whole-slide images and image patch extraction, we trained and optimized an EfficientNet convolutional neuronal network algorithm on 84,139 image patches from 629 patients and evaluated its potential to classify tumor-free reference lymph nodes, nodal small lymphocytic lymphoma/chronic lymphocytic leukemia, and nodal diffuse large B-cell lymphoma. The optimized algorithm achieved an accuracy of 95.56% on an independent test set including 16,960 image patches from 125 patients after the application of quality controls. Automatic classification of NHL is possible with high accuracy using deep learning on histopathological images and routine diagnostic applications should be pursued.

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