A Novel Human Bone Infection Organ Model for Biomaterial Research

2021 ◽  
Author(s):  
Theodor Kuehling ◽  
Pia Schilling ◽  
Anke Bernstein ◽  
Hermann O. Mayr ◽  
Annerose Serr ◽  
...  
Keyword(s):  
Bone Infection ◽  
Human Bone ◽  
Organ Model

Anti-biofilm activity of dalbavancin against methicillin-resistant Staphylococcus aureus (MRSA) isolated from human bone infection

2021 ◽  
pp. 1-6
Author(s):  
Vanessa Silva ◽  
Carla Miranda ◽  
Mário Bezerra ◽  
H. Sofia Antão ◽  
João Guimarães ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Bone Infection ◽  
Human Bone ◽  
Methicillin Resistant

scholarly journals Propionibacterium namnetense sp. nov., isolated from a human bone infection

2016 ◽  
Vol 66 (9) ◽  
pp. 3393-3399 ◽  
Author(s):  
Guillaume Ghislain Aubin ◽  
Pascale Bémer ◽  
Stanimir Kambarev ◽  
Nisha B. Patel ◽  
Olivier Lemenand ◽  
...  
Keyword(s):  
Bone Infection ◽  
Human Bone

Buttiauxella massiliensis sp. nov., Isolated from a Human Bone Infection

2022 ◽  
Vol 79 (2) ◽  
Author(s):  
Rita Zgheib ◽  
Issam Hasni ◽  
Babacar Mbaye ◽  
Hussein Anani ◽  
Gabriel Haddad ◽  
...  
Keyword(s):  
Bone Infection ◽  
Human Bone

scholarly journals A Method for the Evaluation of Early Osseointegration of Implant Materials Ex Vivo: Human Bone Organ Model

Materials ◽  
2021 ◽  
Vol 14 (11) ◽  
pp. 3001
Author(s):  
Sergej Zankovic ◽  
Michael Seidenstuecker ◽  
Wolf C. Prall ◽  
Johannes Loos ◽  
Franziska Maderer ◽  
...  
Keyword(s):  
Culture Media ◽  
Ex Vivo ◽  
Human Bone ◽  
Cell Counting ◽  
In Vitro Tests ◽  
Implant Materials ◽  
Replacement Surgery ◽  
Organ Model ◽  
Total Knee

In the present work, an ex vivo organ model using human bone (explant) was developed for the evaluation of the initial osseointegration behavior of implant materials. The model was tested with additive manufactured Ti6Al4V test substrates with different 3D geometries. Explants were obtained from patients who underwent total knee replacement surgery. The tibial plateaus were used within 24 h after surgery to harvest bone cylinders (BC) from the anterior side using hollow burrs. The BCs were brought into contact with the test substrate and inserted into an agarose mold, then covered with cell culture media and subjected to the external load of 500 g. Incubation was performed for 28 days. After 28d the test substrate was removed for further analysis. Cells grown out BC onto substrate were immunostained with DAPI and with an antibody against Collagen-I and alkaline phosphatase (ALP) for visualization and cell counting. We show that cells stayed alive for up to 28d in our organ model. The geometry of test substrates influences the number of cells grown onto substrate from BCs. The model presented here can be used for testing implant materials as an alternative for in vitro tests and animal models.

Severe human bone infection due to methicillin-resistant Staphylococcus aureus carrying the novel mecC variant

2013 ◽  
Vol 68 (12) ◽  
pp. 2949-2950 ◽  
Author(s):  
O. Barraud ◽  
F. Laurent ◽  
B. Francois ◽  
M. Bes ◽  
P. Vignon ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Bone Infection ◽  
Human Bone ◽  
The Novel ◽  
Methicillin Resistant

The human bone marrow (BM) niche in acute leukaemia

2017 ◽  
Author(s):  
D Pal ◽  
H Blair ◽  
S Boyd ◽  
P Bakelis ◽  
A Elder ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Acute Leukaemia ◽  
Human Bone ◽  
Human Bone Marrow ◽  
Bm Niche

Author response for "Modelling the Human Bone‐Tumour Niche ‐ reducing and replacing the need for animal data"

2020 ◽  
Author(s):  
Srinivasa R. Rao ◽  
Claire M. Edwards ◽  
James R. Edwards
Keyword(s):  
Bone Tumour ◽  
Human Bone ◽  
Author Response ◽  
Animal Data
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