Environmental Impact of the Reported Chromatographic Methods for the Determination of the First FDA-Approved Therapy for COVID-19 Patients, Remdesivir: A Comparative Study

2021 ◽  
Author(s):  
Amal B. Ahmed ◽  
Mohammed Gamal ◽  
Ibrahim A. Naguib ◽  
Hazim Ali ◽  
Fatma F. Abdallah
Keyword(s):  
Environmental Impact ◽  
Comparative Study ◽  
Chromatographic Methods

Comparative study of liquid chromatographic methods for the determination of cefadroxil

1993 ◽  
Vol 634 (2) ◽  
pp. 257-261 ◽  
Author(s):  
C. Hendrix ◽  
Yongxin Zhu ◽  
C. Wijsen ◽  
E. Roets ◽  
J. Hoogmartens
Keyword(s):  
Comparative Study ◽  
Chromatographic Methods ◽  
Liquid Chromatographic

scholarly journals Combined Approach to the Choice of Chromatographic Methods for Routine Determination of Hederacoside C in Ivy Leaf Extracts, Capsules, and Syrup

2020 ◽  
Vol 88 (2) ◽  
pp. 24 ◽  
Author(s):  
Ivan Bezruk ◽  
Alla Kotvitska ◽  
Iuliia Korzh ◽  
Anna Materiienko ◽  
Svitlana Gubar ◽  
...  
Keyword(s):  
Environmental Impact ◽  
Solid Phase ◽  
Economic Cost ◽  
Leaf Extracts ◽  
Green Method ◽  
Chromatographic Methods ◽  
Analytical Accuracy ◽  
Acquity Uplc ◽  
Anhydrous Formic Acid

Developed methods for routine analysis of medicines should be considered in terms of analytical efficiency, economic cost, as well as their environmental impact. Different chromatographic methods for the routine quantitative analysis of hederacoside C in ivy leaf extract and its original dosage forms (capsules and syrup) are developed. The performance of HPLC and UPLC methods should be done using ACE C18 (150 mm × 4.6 mm, 5.0 μm) and ACQUITY UPLC BEH C18 (50 mm × 2.1 mm, 1.7 μm) columns, respectively, and both of them require a mixture of water and acetonitrile in the ratio 71/29 as a mobile phase. The HPTLC procedure is carried out using the stationary phase pre-coated silica gel 60 F254 glass sheets and a mixture of anhydrous formic acid/acetone/methanol/ethyl acetate (4:20:20:30 v/v). The most suitable conditions of preparation for each sample are established, for instance, the solid-phase extraction (SPE) for the analysis of syrup is applied. Analytical methods are compered by analytical accuracy, calculation of expenses, and assessment of their influence on ecology. All methods are recognized as accurate, precise, and reliable. However, the assessment of the environmental impact shows that HPTLC is the less green method. On the another hand, it is found to be the cheapest, the costs of performing HPTLC are 2.3 and 1.6 times lower than for HPLC and UPLC, respectively.

Determination of trace amounts of sulfur in hydrotreated naphthas: comparative study using Raney nickel, Houston Atlas and gas chromatographic methods

The Analyst ◽  
1995 ◽  
Vol 120 (5) ◽  
pp. 1577 ◽  
Author(s):  
Mohamed M. Abdillahi ◽  
Khurshid Alam ◽  
Abdul Bari ◽  
M. Siddiqui ◽  
Mohammed A. Ali
Keyword(s):  
Comparative Study ◽  
Raney Nickel ◽  
Chromatographic Methods
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