scholarly journals Plasma membrane coenzyme Q: evidence for a role in autism

2014 ◽  
pp. 199 ◽  
Author(s):  
Anna Gvozdjáková ◽  
Hans Low ◽  
Iris Sun ◽  
Placido Navas ◽  
Frederick Crane
Keyword(s):  
Plasma Membrane ◽  
Coenzyme Q

scholarly journals Coenzyme Q reductase from liver plasma membrane: purification and role in trans-plasma-membrane electron transport.

1995 ◽  
Vol 92 (11) ◽  
pp. 4887-4891 ◽  
Author(s):  
J. M. Villalba ◽  
F. Navarro ◽  
F. Cordoba ◽  
A. Serrano ◽  
A. Arroyo ◽  
...  
Keyword(s):  
Plasma Membrane ◽  
Electron Transport ◽  
Coenzyme Q ◽  
Liver Plasma Membrane ◽  
Plasma Membrane Electron Transport ◽  
In Trans

NADH and NADPH-Dependent Reduction of Coenzyme Q at the Plasma Membrane

2000 ◽  
Vol 2 (2) ◽  
pp. 251-262 ◽  
Author(s):  
Antonio Arroyo ◽  
Valerian E. Kagan ◽  
Vladimir A. Tyurin ◽  
John R. Burgess ◽  
Rafael de Cabo ◽  
...  
Keyword(s):  
Plasma Membrane ◽  
Coenzyme Q

scholarly journals Coenzyme Q is irreplaceable by demethoxy-coenzyme Q in plasma membrane ofCaenorhabditis elegans

FEBS Letters ◽  
2006 ◽  
Vol 580 (7) ◽  
pp. 1740-1746 ◽  
Author(s):  
Antonio Arroyo ◽  
Carlos Santos-Ocaña ◽  
Macarena Ruiz-Ferrer ◽  
Sergio Padilla ◽  
Ángela Gavilán ◽  
...  
Keyword(s):  
Plasma Membrane ◽  
Coenzyme Q

A Phospholipid-Dependent NADH-Coenzyme Q Reductase from Liver Plasma Membrane

1995 ◽  
Vol 212 (1) ◽  
pp. 138-143 ◽  
Author(s):  
F. Navarro ◽  
J.M. Villalba ◽  
F.L. Crane ◽  
W.C. Mackellar ◽  
P. Navas
Keyword(s):  
Plasma Membrane ◽  
Coenzyme Q ◽  
Liver Plasma Membrane

Evidence for a relation between plasma membrane coenzyme Q and autism

10.2741/e680 ◽  
2013 ◽  
Vol E5 (3) ◽  
pp. 1011-1016 ◽  
Author(s):  
Frederick L Crane
Keyword(s):  
Plasma Membrane ◽  
Coenzyme Q

The importance of plasma membrane coenzyme Q in aging and stress responses

Mitochondrion ◽  
2007 ◽  
Vol 7 ◽  
pp. S34-S40 ◽  
Author(s):  
Plácido Navas ◽  
José Manuel Villalba ◽  
Rafael de Cabo
Keyword(s):  
Plasma Membrane ◽  
Stress Responses ◽  
Coenzyme Q

scholarly journals Requirement for coenzyme Q in plasma membrane electron transport.

1992 ◽  
Vol 89 (23) ◽  
pp. 11126-11130 ◽  
Author(s):  
I. L. Sun ◽  
E. E. Sun ◽  
F. L. Crane ◽  
D. J. Morre ◽  
A. Lindgren ◽  
...  
Keyword(s):  
Plasma Membrane ◽  
Electron Transport ◽  
Coenzyme Q ◽  
Plasma Membrane Electron Transport

Ceramide-dependent Caspase 3 Activation is Prevented by Coenzyme Q from Plasma Membrane in Serum-deprived Cells

2002 ◽  
Vol 36 (4) ◽  
pp. 369-374 ◽  
Author(s):  
P. Navas ◽  
D.M. Fernandez-Ayala ◽  
S.F. Martin ◽  
G. Lopez-Lluch ◽  
R. De Cabo ◽  
...  
Keyword(s):  
Plasma Membrane ◽  
Caspase 3 ◽  
Coenzyme Q

Surface oxidase and oxidative stress propagation in aging

2000 ◽  
Vol 203 (10) ◽  
pp. 1513-1521
Author(s):  
D.M. Morre ◽  
G. Lenaz ◽  
D.J. Morre
Keyword(s):  
Reactive Oxygen Species ◽  
Plasma Membrane ◽  
Cell Surface ◽  
Nadh Oxidase ◽  
Coenzyme Q ◽  
Reactive Oxygen ◽  
Terminal Oxidase ◽  
Oxygen Species ◽  
Transport Chain ◽  
Hydroquinone Oxidase

This report summarizes new evidence for a plasma-membrane-associated hydroquinone oxidase designated as CNOX (constitutive plasma membrane NADH oxidase) that functions as a terminal oxidase for a plasma membrane oxidoreductase (PMOR) electron transport chain to link the accumulation of lesions in mitochondrial DNA to cell-surface accumulations of reactive oxygen species. Previous considerations of plasma membrane redox changes during aging have lacked evidence for a specific terminal oxidase to catalyze a flow of electrons from cytosolic NADH to molecular oxygen (or to protein disulfides). Cells with functionally deficient mitochondria become characterized by an anaerobic metabolism. As a result, NADH accumulates from the glycolytic production of ATP. Elevated PMOR activity has been shown to be necessary to maintain the NAD(+)/NADH homeostasis essential for survival. Our findings demonstrate that the hyperactivity of the PMOR system results in an NADH oxidase (NOX) activity capable of generating reactive oxygen species at the cell surface. This would serve to propagate the aging cascade both to adjacent cells and to circulating blood components. The generation of superoxide by NOX forms associated with aging is inhibited by coenzyme Q and provides a rational basis for the anti-aging activity of circulating coenzyme Q.

Role of cytochrome b5 reductase on the antioxidant function of coenzyme Q in the plasma membrane

1997 ◽  
Vol 18 ◽  
pp. 7-13 ◽  
Author(s):  
J.M. Villalba ◽  
F. Navarro ◽  
C. Gómez-Díaz ◽  
A. Arroyo ◽  
R.I. Bello ◽  
...  
Keyword(s):  
Plasma Membrane ◽  
Coenzyme Q ◽  
Cytochrome B5 ◽  
Cytochrome B5 Reductase ◽  
Antioxidant Function
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