scholarly journals Predictors of poorly developed coronary collateral circulation in patients with subclinical hypothyroidism suffered from chronic stable angina

2019 ◽  
Vol 2019 (2) ◽  
Author(s):  
Mohamed Khalfallah ◽  
Enas Draz ◽  
Khaled Shalaby ◽  
Yasser Mostafa Hafez
Keyword(s):  
Coronary Artery ◽  
Subclinical Hypothyroidism ◽  
Stable Angina ◽  
Collateral Circulation ◽  
Chronic Stable Angina ◽  
Multivariate Regression Analysis ◽  
Total Occlusion ◽  
Coronary Collateral Circulation ◽  
Coronary Collaterals ◽  
Coronary Collateral

Background: The development of coronary collaterals is variable among patients with coronary artery disease and remains incompletely understood. We aimed to demonstrate the predictors of poorly developed coronary collateral circulation (CCC) in patients with subclinical hypothyroidism suffered from chronic stable angina.Methods: The study was conducted on 226 patients with subclinical hypothyroidism suffered from chronic stable angina, coronary angiography documented total occlusion at any major coronary artery or coronary artery lumen diameter stenosis ˃90%. Patients were divided into two groups according to grade of CCC, group A: 138 patients with (good collaterals) and group B: 88 patients with (poor collaterals). To classify CCC, we used Rentrop’s classification.Results: Multivariate regression analysis was performed and identified the independent predictors of poor coronary collaterals: N/L ratio (OR 0.413, CI95% 0.172–0.993, p=0.048), and TSH (OR 2.511, CI95% 1.784– 3.534, p=0.001). The ROC analysis provided a cut-off value of >4.6 for N/L ratio, and >9 μIU/mL for TSH to predict poor coronary collaterals.Conclusion: An elevated level of N/L ratio ˃ 4.6 and TSH level ˃ 9 μIU/mL were the independent predictors of poorly developed CCC in patients with subclinical hypothyroidism suffered from chronic stable angina.

scholarly journals Study of Coronary Collaterals in Patients with Stable Angina

1970 ◽  
Vol 6 (2) ◽  
pp. 61-64
Author(s):  
Jahan Ara Arzu ◽  
Fazlur Rahman ◽  
KMHS Sirajul Haque ◽  
Md Abu Siddique ◽  
Md Khairul Anam ◽  
...  
Keyword(s):  
Angina Pectoris ◽  
Stable Angina ◽  
Collateral Circulation ◽  
Stable Angina Pectoris ◽  
Alternative Source ◽  
Coronary Collateral Circulation ◽  
Coronary Collaterals ◽  
Coronary Collateral ◽  
Group A ◽  
Group B

Background: Coronary collateral circulation is an alternative source of blood supply to the myocardium in coronary atherosclerotic disease. They provide adequate flow to the major epicardial branches of the coronary artery. Indicator of cardiac ischemia like stable angina pectoris may determine the presence of coronary collateral circulation.Methods and results: In this prospective observational cross sectional study, 150 patients with stable angina pectoris with or without MI (myocardial infarction) and or coronary intervention were enrolled. Presence of coronary collaterals in coronary angiogram was defined as Rentrop grade > 1. Patients were divided into two groups. Group A patients having Rentrop grade 0 and Group B patients are with collateral circulation, having Rentrop grade 1-3. Patients are compared in these groups. Total (63%) patients with stable angina were in Group B with coronary collateral circulation and only (37%) patients with stable angina pectoris were in Group A without collaterals.Conclusions: The incidence of development of coronary collaterals was significantly higher in patients with stable angina pectoris. DOI: 10.3329/uhj.v6i2.7245University Heart Journal Vol. 6, No. 2, July 2010 pp.61-64

Endocan Levels and Coronary Collateral Circulation in Stable Angina Pectoris: A Pilot Study

Angiology ◽  
2017 ◽  
Vol 69 (1) ◽  
pp. 43-48 ◽  
Author(s):  
Murat Gok ◽  
Harun Kundi ◽  
Emrullah Kiziltunc ◽  
Canan Topcuoglu ◽  
Ender Ornek
Keyword(s):  
Angina Pectoris ◽  
Stable Angina ◽  
Collateral Circulation ◽  
Chronic Stable Angina ◽  
Multivariate Logistic Regression Analysis ◽  
High Sensitivity ◽  
Enzyme Linked Immunosorbent Assay ◽  
Stable Angina Pectoris ◽  
Coronary Collateral Circulation ◽  
Coronary Collateral

We investigated the relationship between endocan (a marker of systemic inflammation) and the development of coronary collateral circulation (CCC) as evaluated by coronary angiography in patients with chronic stable angina pectoris. A total of 90 patients (32 poor CCC and 58 good CCC) were included in this study. Endocan levels were determined using a commercially available sandwich enzyme-linked immunosorbent assay kit with high sensitivity and specificity for detection of human endocan. In multivariate logistic regression analysis, low endocan levels were independently associated with good CCC ( P < .001). Moreover, low high-sensitivity C-reactive protein levels were also independently associated with good CCC ( P = .020). We found an optimal cutoff point for endocan of 1.7 ng/mL; it predicted the presence of good CCC with a sensitivity of 72.4% and specificity of 65.6% ( P < .001). The results of the present study suggest that measurement of endocan level may help clinicians to predict the development of CCC in patients with stable coronary artery disease.

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