Changes of Macular Vessel Density in Primary Open Angle Glaucoma

Abstract Purpose: To evaluate the relationship between structure and function in moderate and advanced primary open-angle glaucoma (POAG) and to determine the accuracy of structure and vasculature for discriminating moderate from advanced POAG.Methods: In this cross-sectional study 25 eyes with moderate and 40 eyes with advanced POAG were enrolled. All eyes underwent measurement of the thickness of circumpapillary retinal nerve fiber layer (cpRNFL) and macular ganglion cell complex (GCC), and optical coherence tomography angiography (OCTA) of the optic nerve head (ONH) and macula. Visual field (VF) was evaluated by Swedish interactive threshold algorithm and 24-2 and 10-2 patterns. The correlation between structure and vasculature and the mean deviation (MD) of the VFs was evaluated by a partial correlation coefficient. The area under the receiver operating characteristic curve (AUC) was applied for assessing the power of variables for discrimination moderate from advanced POAG.Results: Superior cpRNFL, superior GCC, whole image vessel density (wiVD) of the ONH area, and vessel density in inferior quadrant of perifovea had the strongest correlation with the mean deviation (MD) of the VF 24-2 (r= .351, .558, .649 and .397; p< .05). The greatest AUCs belonged to inferior cpRNFL (.789), superior GCC (.818), vessel density of the inferior hemifield of ONH area (.886), and vessel density in inferior quadrant of perifovea (.833) without statistically significant difference in pairwise comparison.Conclusion: Vasculature has a stronger correlation than the structure with MD in moderate and advanced POAG and is as accurate as structure in discrimination moderate from advanced POAG.

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Correlations Between Macula Vessel Density and Macula Thickness in Early Stage of Primary Open-Angle Glaucoma

Nigerian Journal of Ophthalmology ◽

10.4103/njo.njo_31_18 ◽

2019 ◽

Vol 27 (1) ◽

pp. 22

Author(s):

UsmanBosso Abubakar ◽

MarchenkoLudmilla Nikolaevna ◽

DzhumovaMarina Fedrovna ◽

KachanTatsiana Vladimerovna ◽

DalidovichAnastasiya Aleksandrovna ◽

...

Keyword(s):

Primary Open Angle Glaucoma ◽

Early Stage ◽

Open Angle Glaucoma ◽

Vessel Density ◽

Open Angle

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Comparison of vessel density in macular and peripapillary regions between primary open-angle glaucoma and pseudoexfoliation glaucoma using OCTA

International Ophthalmology ◽

10.1007/s10792-020-01564-5 ◽

2020 ◽

Author(s):

Sevgi Subasi ◽

Nursen Yuksel ◽

Ece Basaran ◽

Dilara Pirhan

Keyword(s):

Primary Open Angle Glaucoma ◽

Open Angle Glaucoma ◽

Vessel Density ◽

Open Angle ◽

Pseudoexfoliation Glaucoma

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Optical coherence tomography angiography vessel density parameters in primary open-angle glaucoma

Annals of Medicine and Surgery ◽

10.1016/j.amsu.2021.102671 ◽

2021 ◽

pp. 102671

Author(s):

Oumayma Khayrallah ◽

Ahmed Mahjoub ◽

Nadia Ben abdesslam ◽

Anis Mahjoub ◽

Mohamed Ghorbel ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Optical Coherence Tomography Angiography ◽

Primary Open Angle Glaucoma ◽

Open Angle Glaucoma ◽

Vessel Density ◽

Optical Coherence ◽

Open Angle

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A comparison of the diagnostic ability of vessel density and structural measurements of optical coherence tomography in primary open angle glaucoma

PLoS ONE ◽

10.1371/journal.pone.0173930 ◽

2017 ◽

Vol 12 (3) ◽

pp. e0173930 ◽

Cited By ~ 47

Author(s):

Harsha L. Rao ◽

Zia S. Pradhan ◽

Robert N. Weinreb ◽

Mohammed Riyazuddin ◽

Srilakshmi Dasari ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Primary Open Angle Glaucoma ◽

Open Angle Glaucoma ◽

Vessel Density ◽

Optical Coherence ◽

Open Angle ◽

Diagnostic Ability

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Diurnal fluctuations of macular vessel density in patients with primary open-angle glaucoma and healthy subjects

International Ophthalmology ◽

10.1007/s10792-020-01408-2 ◽

2020 ◽

Vol 40 (9) ◽

pp. 2257-2266

Author(s):

Xiaojie Wang ◽

Juanjuan Chen ◽

Shaodan Zhang ◽

Xiao Shang ◽

Kun Zhou ◽

...

Keyword(s):

Healthy Subjects ◽

Primary Open Angle Glaucoma ◽

Open Angle Glaucoma ◽

Vessel Density ◽

Open Angle ◽

Diurnal Fluctuations

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Macular vessel density versus ganglion cell complex thickness for detection of early primary open-angle glaucoma

BMC Ophthalmology ◽

10.1186/s12886-020-1304-x ◽

2020 ◽

Vol 20 (1) ◽

Author(s):

Yiwei Wang ◽

Chen Xin ◽

Meng Li ◽

David L. Swain ◽

Kai Cao ◽

...

Keyword(s):

Ganglion Cell ◽

Primary Open Angle Glaucoma ◽

Open Angle Glaucoma ◽

Case Series ◽

Cell Complex ◽

Vessel Density ◽

Ganglion Cell Complex ◽

Open Angle ◽

Percent Reduction ◽

Healthy Eyes

Abstract Background To evaluate the macular vessel density (VD) and ganglion cell complex (GCC) thickness in pre-perimetric (PPG) and early perimetric primary open-angle glaucoma (PG) eyes, and to compare the diagnostic ability of the two measurements to discriminate PPG and early PG eyes from healthy eyes. Methods Seventy-nine eyes in 72 subjects (31 normal, 26 PPG, and 22 early PG eyes) were included in the consecutive case series. Macular VD and GCC thickness were acquired simultaneously using the 6 × 6 mm2 high-density AngioRetina scanning mode. Diagnostic abilities were assessed using the area under the receiver operating characteristic curve (AUROC). Results Compared to healthy eyes, whole image VD (wiVD) and GCC thickness were significantly lower in PPG and early PG eyes (all P < 0.025). The percent reduction of wiVD was lower than that of GCC thickness in early PG eyes (P < 0.05), while they were similar in PPG eyes (P > 0.05). Regionally, greater VD attenuation and GCC thinning were identified in the perifovea than in the parafovea in both groups (all P < 0.05). Moreover, the percent reduction of VD was less than that of GCC thickness in the perifoveal region in PPG eyes (P < 0.05). The AUROCs for wiVD and GCC thickness were 0.824 and 0.881, respectively, in PPG eyes (P > 0.05), and 0.918 and 0.977, respectively, in early PG eyes (P > 0.05). Conclusions Macular VD and GCC thickness significantly decreased in PPG and early PG eyes. The perifoveal region appeared to be more vulnerable to macular VD attenuation and GCC thinning in early glaucoma. Our results showed that macular VD measurements may be helpful for detecting and understanding early glaucomatous damage.

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Quantitative assessment of macular and peripapillary microvasculature using optical coherence tomography angiography in glaucomatous versus healthy eyes

QJM ◽

10.1093/qjmed/hcab109.001 ◽

2021 ◽

Vol 114 (Supplement_1) ◽

Author(s):

Amr M Sanad ◽

Mohamed M Mahgoub ◽

Weam M Ebeid ◽

Rabab A Mahmoud

Keyword(s):

Optical Coherence Tomography ◽

Optical Coherence Tomography Angiography ◽

Primary Open Angle Glaucoma ◽

Open Angle Glaucoma ◽

Vessel Density ◽

Optical Coherence ◽

Open Angle ◽

University Hospitals ◽

Microvascular Changes ◽

Group 2

Abstract Background Glaucoma is the leading cause of irreversible blindness worldwide. With the growing burden of glaucoma, we looked for better tools for early diagnosis and monitoring. Aim of the Work using optical coherence tomography angiography (OCTA) vessel density (VD) to document, quantify and compare microvasculature changes in macula and peripapillary region between healthy and moderate to severe primary open angle glaucoma eyes. Patients and Methods A comparative interventional prospective study was conducted on 28 eyes of 14 subjects, recruited from Ain Shams University hospitals outpatient clinic, and were subjected to imaging procedure during the period from January 2020 to May 2020. Subjects were divided into two groups: Group 1 of 14 eyes of 9 patients with moderate to severe primary open angle glaucoma (POAG), and group 2 of 14 eyes of 7 healthy sex and age-matched controls. Results a statistically significant decrease was found in VD in the peripapillary region (P < 0.001) and superficial macular regions in glaucoma subjects (P < 0.001). Conclusion OCTA proved a quantitative decrease in both peripapillary and macular vessel density as a parameter of microvascular changes associated with moderate to severe POAG. These results reflect damage to tissues relevant to the pathophysiology of POAG demonstrating OCTA importance with respect to diagnosing glaucoma and understanding the pathophysiology of this disease and, guiding future studies to evaluate more potential uses of this technology in the actual assessment of patients with glaucoma.

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