Dose Linearity of Lacidipine Pharmacokinetics After Single and Repeated Oral Doses in Healthy Volunteers

2003 ◽  
Vol 42 (1) ◽  
pp. 99-106 ◽  
Author(s):  
Lucio Da Ros ◽  
Lisa Squassante ◽  
Stefano Milleri
Keyword(s):  
Healthy Volunteers ◽  
Dose Linearity ◽  
Oral Doses

Tolerability of Increasing Single Oral Doses of Clentiazem in Healthy Volunteers

1992 ◽  
Vol 4 (3) ◽  
pp. 276-282 ◽  
Author(s):  
Jean-Marie Houle ◽  
Pierre Major ◽  
John McCans ◽  
Hélène Landriault ◽  
Marc LeFebvre ◽  
...  
Keyword(s):  
Healthy Volunteers ◽  
Oral Doses

Inhibition of Platelet Aggregation in Man by Indobufen (K 3920)

1981 ◽  
Vol 9 (1) ◽  
pp. 12-17 ◽  
Author(s):  
A Vittoria ◽  
F Laghi Pasini ◽  
G L Messa ◽  
T Di Perri ◽  
G Corvi ◽  
...  
Keyword(s):  
Platelet Aggregation ◽  
Healthy Volunteers ◽  
Crossover Trial ◽  
Marked Effect ◽  
Threshold Concentration ◽  
Dose Effect ◽  
Inhibition Of Platelet Aggregation ◽  
Oral Doses

A complete crossover trial was undertaken in six healthy volunteers to gain information on dose-effect responses to indobufen by assessing the intensity and duration of the effect of 3 single oral doses of the drug on platelet aggregation induced by threshold concentration of ADP and by 3 added doses of collagen. The results of the study confirm that the activity is dose-related and is reversible since 24 hours after administration it has practically disappeared. The effect of the same dose of indobufen differed significantly according to the amount of collagen added to plasma, whereas increasing doses of indobufen provoked a significantly more marked effect when the amount of inducer employed was the same.

scholarly journals Suction-induced blister fluid penetration of cefdinir in healthy volunteers following ascending oral doses

1995 ◽  
Vol 39 (5) ◽  
pp. 1082-1086 ◽  
Author(s):  
M. Richer ◽  
S. Allard ◽  
L. Manseau ◽  
F. Vallee ◽  
R. Pak ◽  
...  
Keyword(s):  
Healthy Volunteers ◽  
Blister Fluid ◽  
Fluid Penetration ◽  
Oral Doses

scholarly journals Effects of Single Oral Doses of Gemifloxacin (320 Milligrams) versus Trovafloxacin (200 Milligrams) on Fecal Flora in Healthy Volunteers

2001 ◽  
Vol 45 (2) ◽  
pp. 608-611 ◽  
Author(s):  
Gloria Garcia-Calvo ◽  
Ana Molleja ◽  
Maria J. Giménez ◽  
Araceli Parra ◽  
Eva Nieto ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Healthy Volunteers ◽  
Washout Period ◽  
Crossover Trial ◽  
Fecal Flora ◽  
Randomized Crossover Trial ◽  
The Family ◽  
Stool Samples ◽  
Resistant Strains ◽  
Oral Doses

ABSTRACT Gemifloxacin and trovafloxacin were administered to 12 volunteers in a randomized crossover trial with a 2-week washout period. Stool samples were collected predose and 1, 2, and 3 days postdose. Both quinolones reduced the number of organisms of the familyEnterobacteriaceae and aerobic gram-positive organisms. Escherichia coli reduction was greater with gemifloxacin than with trovafloxacin, with postdose isolation of quinolone-resistant strains for which MICs of trovafloxacin were higher than those of gemifloxacin.

DOSE LINEARITY ASSESSMENT OF GLIMEPIRIDE (AMARYL®) TABLETS IN HEALTHY VOLUNTEERS

1994 ◽  
Vol 11 (4) ◽  
Author(s):  
V. Malerczyk ◽  
M. Badian ◽  
A. Korn ◽  
K.-H. Lehr ◽  
W. Waldhäusl
Keyword(s):  
Healthy Volunteers ◽  
Dose Linearity
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