scholarly journals Non-superiority of Kakkonto, a Japanese Herbal Medicine, to a Representative Multiple Cold Medicine with Respect to Anti-aggravation Effects on the Common Cold: A Randomized Controlled Trial

2014 ◽  
Vol 53 (9) ◽  
pp. 949-956 ◽  
Author(s):  
Satoe Okabayashi ◽  
Masashi Goto ◽  
Takashi Kawamura ◽  
Hidetsuna Watanabe ◽  
Akira Kimura ◽  
...  
2004 ◽  
Vol 12 (4) ◽  
pp. 181-188 ◽  
Author(s):  
Kenji Kawakita ◽  
Toshiyuki Shichidou ◽  
Etsuko Inoue ◽  
Tomoyuki Nabeta ◽  
Hiroshi Kitakouji ◽  
...  

2015 ◽  
Vol 143 (12) ◽  
pp. 2494-2502 ◽  
Author(s):  
T. P. ZOMER ◽  
V. ERASMUS ◽  
C. W. LOOMAN ◽  
A. TJON-A-TSIEN ◽  
E. F. VAN BEECK ◽  
...  

SUMMARYInfections are common in children attending daycare centres (DCCs). We evaluated the effect of a hand hygiene (HH) intervention for caregivers on the incidence of gastrointestinal and respiratory infections in children. The intervention was evaluated in a two-arm cluster randomized controlled trial. Thirty-six DCCs received the intervention including HH products, training sessions, and posters/stickers. Thirty-five control DCCs continued usual practice. Incidence of episodes of diarrhoea and the common cold in children was monitored by parents during 6 months. Using multilevel Poisson regression, incidence rate ratios (IRRs) with 95% confidence intervals (CIs) were obtained. Diarrhoeal incidence was monitored in 545 children for 91 937 days. During follow-up, the incidence was 3·0 episodes per child-year in intervention DCCs vs. 3·4 in control DCCs (IRR 0·90, 95% CI 0·73–1·11). Incidence of the common cold was monitored in 541 children for 91 373 days. During follow-up, the incidence was 8·2 episodes per child-year in intervention DCCs vs. 7·4 in control DCCs (IRR 1·07, 95% CI 0·97–1·19). In this study, no evidence for an effect of the intervention was demonstrated on the incidence of episodes of diarrhoea and the common cold.


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