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<p>Existing methods for making MIDA boronates require harsh conditions and complex procedures to achieve dehydration. Here we
disclose that a pre-dried form of MIDA, MIDA anhydride, acts as both a source of the MIDA ligand and an in situ desiccant to enable a
mild and simple MIDA boronate synthesis procedure. This method expands the range of sensitive boronic acids that can be converted
into their MIDA boronate counterparts. Further utilizing unique properties of MIDA boronates, we have developed a MIDA Boronate
Maker Kit which enables the direct preparation and purification of MIDA boronates from boronic acids using only heating and centrifuge
equipment that is widely available in labs that do not specialize in organic synthesis. </p>
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A CF3SO2Na/Pd(OAc)2 co-catalyzed strategy is developed to produce aryl ketones via visible-light-induced decarboxylative cross-coupling of α-oxocarboxylic acids and aryl boronic acids. This process was perfomed under air at room temperature,...
The three-starting materials four-component reaction of (trifluoromethyl)alkenes, TBHP, and boronic acids is reported, delivering various useful α-trifluoromethyl-β-aryloxy tertiary alcohols in high yields and in an exclusively regioselective hydroetherification manner. TBHP serves as both the oxidants and the nucleophiles in this reaction, as well as the O-source of the products.
