Editorial [Hot Topic: Sigma Receptor Research: Progress Towards Diagnostic and Therapeutic Uses of Sigma Ligands (Executive Guest Editor: Carmen Abate )]

2012 ◽  
Vol 18 (7) ◽  
pp. 861-862 ◽  
Author(s):  
Carmen Abate
Keyword(s):  
Guest Editor ◽  
Research Progress ◽  
Sigma Receptor ◽  
Therapeutic Uses ◽  
Sigma Ligands ◽  
Receptor Research

Sigma ligands stimulate GTPase activity in mouse prefrontal membranes: evidence for the existence of metabotropic sigma receptor

1997 ◽  
Vol 233 (2-3) ◽  
pp. 141-144 ◽  
Author(s):  
Shogo Tokuyama ◽  
Kinya Hirata ◽  
Asuka Ide ◽  
Hiroshi Ueda
Keyword(s):  
Sigma Receptor ◽  
Gtpase Activity ◽  
Sigma Ligands

Melittin: A Natural Peptide with Expanded Therapeutic Applications

2020 ◽  
Vol 10 ◽  
Author(s):  
Ruchi Tiwari ◽  
Gaurav Tiwari ◽  
Akanksha Lahiri ◽  
Vadivelan Ramachandran ◽  
Awani Rai
Keyword(s):  
Bee Venom ◽  
Research Progress ◽  
Cellular Functions ◽  
Venom Component ◽  
Therapeutic Applications ◽  
Therapeutic Uses ◽  
Infected Cells ◽  
Broad Variety ◽  
Natural Peptide ◽  
Therapeutic Activities

Background: Apis mellifera, European honey bee venom (BV) is a complex combination of chemical compounds comprising proteins, peptides, enzymes, and other small molecules. Melittin (MEL), which is the key component of BV is considered as an alternative for treatment of various infections. MEL is an amphipathic, cell-penetrating, 26-residue, ahelical anti-hepatoma peptide derived from BV. However, owing to its initial conformational strength and poor stability, melittin is constrained in use as a medication. Objective: The study focused on collective data of therapeutic activities of Bee venom component, MEL. Method: Regardless of its broad variety of biological and possible therapeutic uses, there has been increasing concern in the use of MEL. According to literature, MEL revealed range of activities started from Anti- cancer activity, Anti- microbial activity, Anti- viral activity, Anti-inflammatory activity to Anti- diabetic activity. Present review article summarized therapeutic applications of MEL, their mechanism of action along with recent research progress in field of its delivery. Conclusion: It could be concluded that MEL exerts multiple effects on cellular functions of infected cells.

Guest Editor

2007 ◽  
Vol 16 (2) ◽  
pp. 2-2
Author(s):  
Joanne Cafiero
Keyword(s):  
Guest Editor

FROM THE GUEST EDITOR—SEEKING BALANCE IN COMPLEXITY

2001 ◽  
Vol 22 (5) ◽  
pp. 457-459
Author(s):  
Margaret Cotroneo
Keyword(s):  
Guest Editor

Which Data to Meta-Analyze, and How?

2019 ◽  
Vol 227 (1) ◽  
pp. 64-82 ◽  
Author(s):  
Martin Voracek ◽  
Michael Kossmeier ◽  
Ulrich S. Tran
Keyword(s):  
Empirical Research ◽  
Meta Analysis ◽  
Curve Analysis ◽  
Research Progress ◽  
Primary Data ◽  
Statistical Procedures ◽  
Graphical Displays ◽  
Primary Data Analysis ◽  
Meta Analyses ◽  
Data Analytic

Abstract. Which data to analyze, and how, are fundamental questions of all empirical research. As there are always numerous flexibilities in data-analytic decisions (a “garden of forking paths”), this poses perennial problems to all empirical research. Specification-curve analysis and multiverse analysis have recently been proposed as solutions to these issues. Building on the structural analogies between primary data analysis and meta-analysis, we transform and adapt these approaches to the meta-analytic level, in tandem with combinatorial meta-analysis. We explain the rationale of this idea, suggest descriptive and inferential statistical procedures, as well as graphical displays, provide code for meta-analytic practitioners to generate and use these, and present a fully worked real example from digit ratio (2D:4D) research, totaling 1,592 meta-analytic specifications. Specification-curve and multiverse meta-analysis holds promise to resolve conflicting meta-analyses, contested evidence, controversial empirical literatures, and polarized research, and to mitigate the associated detrimental effects of these phenomena on research progress.

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