Synthesis of N,N'-Diacylhydrazines and their use in Various Synthetic Transformations

: The current work reviews the synthesis of N,N'-diacylhydrazines and their use in various synthetic transformationshave been reviewed. Three synthetic routes are commonly used to produce N,N'-diacylhydrazines. They are produced through the coupling of acyl chlorides and carbohydrazides, the reaction of hydrazine hydrate and carboxylic acids or isocyanates, and the dimerization of carbohydrazides. N,N'-Diacylhydrazines are involved in many synthetic transformations to produce various types of compounds. They can be oxidized to produce the corresponding esters and act as precursors in the synthesis of various heterocycles such as 1,3,4-oxadiazoles, 1,3,4-thiadiazoles, 1,2,4-triazoles, pyrazoles, tetrazines, and crown ethers.