Molecular Modeling-Guided Site-Directed Mutagenesis of Cytochrome P450 2D6

Current Drug Metabolism ◽

10.2174/138920007779315062 ◽

2007 ◽

Vol 8 (1) ◽

pp. 59-77 ◽

Author(s):

Chris de Graaf ◽

Chris Oostenbrink ◽

Peter J. Keizers ◽

Barbara A. van Vugt-Lussenburg ◽

Robert B. van Waterschoot ◽

...

Keyword(s):

Cytochrome P450 ◽

Molecular Modeling ◽

Site Directed Mutagenesis ◽

Directed Mutagenesis ◽

Cytochrome P450 2D6 ◽

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Site-Directed Mutagenesis of Cytochrome P450 2D6 and 2C19 Enzymes: Expression and Spectral Characterization of Naturally Occurring Allelic Variants

Applied Biochemistry and Biotechnology ◽

10.1007/s12010-018-2728-0 ◽

2018 ◽

Vol 186 (1) ◽

pp. 132-144 ◽

Author(s):

Amelia Nathania Dong ◽

Yan Pan ◽

Uma Devi Palanisamy ◽

Beow Chin Yiap ◽

Nafees Ahemad ◽

...

Keyword(s):

Cytochrome P450 ◽

Spectral Characterization ◽

Site Directed Mutagenesis ◽

Directed Mutagenesis ◽

Cytochrome P450 2D6 ◽

Allelic Variants ◽

Naturally Occurring ◽

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Site-Directed Mutagenesis as a Tool for Molecular Modeling of Cytochrome P450 2B1

Biochemistry ◽

10.1021/bi00044a008 ◽

1995 ◽

Vol 34 (44) ◽

pp. 14312-14322 ◽

Author(s):

Grazyna D. Szklarz ◽

You Ai He ◽

James R. Halpert

Keyword(s):

Cytochrome P450 ◽

Molecular Modeling ◽

Site Directed Mutagenesis ◽

Directed Mutagenesis

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Cytochrome P450 2D6 polymorphism in Lebanon. (c2003)

10.26756/th.2003.13 ◽

2003 ◽

Author(s):

Sarita Georges Saade

Keyword(s):

Cytochrome P450 ◽

Cytochrome P450 2D6 ◽

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Faculty Opinions recommendation of Contributions of ionic interactions and protein dynamics to cytochrome P450 2D6 (CYP2D6) substrate and inhibitor binding.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.725297021.793502782 ◽

2015 ◽

Author(s):

John Lowe

Keyword(s):

Cytochrome P450 ◽

Protein Dynamics ◽

Ionic Interactions ◽

Cytochrome P450 2D6 ◽

Inhibitor Binding ◽

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Probing the role of lysines and arginines in the catalytic function of cytochrome P450d by site-directed mutagenesis. Interaction with NADPH-cytochrome P450 reductase

Journal of Biological Chemistry ◽

10.1016/s0021-9258(19)67801-4 ◽

1991 ◽

Vol 266 (6) ◽

pp. 3372-3375

Author(s):

T Shimizu ◽

T Tateishi ◽

M Hatano ◽

Y Fujii-Kuriyama

Keyword(s):

Cytochrome P450 ◽

Site Directed Mutagenesis ◽

Directed Mutagenesis ◽

Cytochrome P450 Reductase ◽

Nadph Cytochrome ◽

P450 Reductase ◽

Catalytic Function ◽

Nadph Cytochrome P450 Reductase

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Structure-function relationships of human aromatase cytochrome P-450 using molecular modeling and site-directed mutagenesis

Journal of Biological Chemistry ◽

10.1016/s0021-9258(18)99048-4 ◽

1991 ◽

Vol 266 (18) ◽

pp. 11939-11946

Author(s):

S. Graham-Lorence ◽

M.W. Khalil ◽

M.C. Lorence ◽

C.R. Mendelson ◽

E.R. Simpson

Keyword(s):

Molecular Modeling ◽

Structure Function ◽

Site Directed Mutagenesis ◽

Directed Mutagenesis ◽

Human Aromatase ◽

Cytochrome P 450

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Increased reactive oxygen species generation in specific mutants of cytochrome P450 2D6

Free Radical Biology and Medicine ◽

10.1016/s0891-5849(98)90056-9 ◽

1998 ◽

Vol 25 ◽

pp. S22

Keyword(s):

Reactive Oxygen Species ◽

Cytochrome P450 ◽

Reactive Oxygen Species Generation ◽

Reactive Oxygen ◽

Oxygen Species ◽

Cytochrome P450 2D6 ◽

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The Association Between Cytochrome P450 2D6 Genotype and Prescription Patterns of Antipsychotic and Antidepressant Drugs in Hospitalized Psychiatric Patients

Journal of Clinical Psychopharmacology ◽

10.1097/01.jcp.0000155832.79777.b5 ◽

2005 ◽

Vol 25 (2) ◽

pp. 188-191 ◽

Author(s):

Hans Mulder ◽

Frederik W. Wilmink ◽

Tim L. Beumer ◽

Wim J. Tamminga ◽

Jaap N. Jedema ◽

...

Keyword(s):

Cytochrome P450 ◽

Psychiatric Patients ◽

Antidepressant Drugs ◽

Cytochrome P450 2D6 ◽

Prescription Patterns ◽

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Probing Small-Molecule Binding to Cytochrome P450 2D6 and 2C9: An In Silico Protocol for Generating Toxicity Alerts

ChemMedChem ◽

10.1002/cmdc.201000358 ◽

2010 ◽

Vol 5 (12) ◽

pp. 2088-2101 ◽

Author(s):

Gianluca Rossato ◽

Beat Ernst ◽

Martin Smiesko ◽

Morena Spreafico ◽

Angelo Vedani

Keyword(s):

Cytochrome P450 ◽

Small Molecule ◽

In Silico ◽

Cytochrome P450 2D6 ◽

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From Genotype to Phenotype: Cytochrome P450 2D6-Mediated Drug Clearance in Humans

Molecular Pharmaceutics ◽

10.1021/acs.molpharmaceut.6b00920 ◽

2017 ◽

Vol 14 (3) ◽

pp. 649-657 ◽

Author(s):

Jie Gao ◽

Xin Tian ◽

Jun Zhou ◽

Ming-Zhu Cui ◽

Hai-Feng Zhang ◽

...

Keyword(s):

Cytochrome P450 ◽

Drug Clearance ◽

Cytochrome P450 2D6 ◽

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