Editorial (Hot Topic: Androgen Receptor and Prostate Cancer: New Insights in an Old Target Translate into Novel Therapeutic Strategies)

2013 ◽  
Vol 14 (4) ◽  
pp. 399-400 ◽  
Author(s):  
Hannelore V. Heemers
Keyword(s):  
Prostate Cancer ◽  
Androgen Receptor ◽  
Therapeutic Strategies ◽  
Novel Therapeutic Strategies ◽  
Novel Therapeutic

scholarly journals Molecular underpinnings of enzalutamide resistance

2018 ◽  
Vol 25 (11) ◽  
pp. R545-R557 ◽  
Author(s):  
S Prekovic ◽  
T Van den Broeck ◽  
S Linder ◽  
M E van Royen ◽  
A B Houtsmuller ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Androgen Receptor ◽  
Clinical Research ◽  
Survival Time ◽  
Therapeutic Strategy ◽  
Therapeutic Strategies ◽  
Effective Therapeutic Strategy ◽  
Novel Therapeutic Strategies ◽  
Improvement In Survival ◽  
Novel Therapeutic

Prostate cancer (PCa) is among the most common adult malignancies, and the second leading cause of cancer-related death in men. As PCa is hormone dependent, blockade of the androgen receptor (AR) signaling is an effective therapeutic strategy for men with advanced metastatic disease. The discovery of enzalutamide, a compound that effectively blocks the AR axis and its clinical application has led to a significant improvement in survival time. However, the effect of enzalutamide is not permanent, and resistance to treatment ultimately leads to development of lethal disease, for which there currently is no cure. This review will focus on the molecular underpinnings of enzalutamide resistance, bridging the gap between the preclinical and clinical research on novel therapeutic strategies for combating this lethal stage of prostate cancer.

scholarly journals Novel Therapeutic Strategies for Metastatic Prostate Cancer in the Post‐Docetaxel Setting

2011 ◽  
Vol 16 (11) ◽  
pp. 1487-1497 ◽  
Author(s):  
Oliver Sartor ◽  
Ross M. Michels ◽  
Christophe Massard ◽  
Johann Sebastian Bono
Keyword(s):  
Prostate Cancer ◽  
Metastatic Prostate Cancer ◽  
Therapeutic Strategies ◽  
Novel Therapeutic Strategies ◽  
Novel Therapeutic
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