Synthesis and Biological Evaluation of 1,5-Naphthyridines as Topoisomerase I Inhibitors. A New Family of Antiproliferative Agents

New Family ◽

Straightforward synthesis and biological evaluation as topoisomerase I inhibitors and antiproliferative agents of hybrid Chromeno[4,3-b][1,5]Naphthyridines and Chromeno[4,3-b][1,5]Naphthyridin-6-ones

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2019.06.032 ◽

2019 ◽

Vol 178 ◽

pp. 752-766 ◽

Cited By ~ 5

Author(s):

Endika Martín-Encinas ◽

Gloria Rubiales ◽

Birgitta R. Knudssen ◽

Francisco Palacios ◽

Concepción Alonso

Keyword(s):

Topoisomerase I ◽

Biological Evaluation ◽

Antiproliferative Agents ◽

Fused chromeno and quinolino[1,8]naphthyridines: synthesis and biological evaluation as topoisomerase I inhibitors and antiproliferative agents

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2021.116177 ◽

2021 ◽

pp. 116177

Author(s):

Endika Martín-Encinas ◽

Gloria Rubiales ◽

Birgitta R. Knudsen ◽

Francisco Palacios ◽

Concepción Alonso

Keyword(s):

Topoisomerase I ◽

Biological Evaluation ◽

Antiproliferative Agents ◽

Design, Synthesis, and Biological Evaluation of Indenoisoquinoline Topoisomerase I Inhibitors Featuring Polyamine Side Chains on the Lactam Nitrogen

Journal of Medicinal Chemistry ◽

10.1021/jm030313f ◽

2003 ◽

Vol 46 (26) ◽

pp. 5712-5724 ◽

Cited By ~ 83

Author(s):

Muthukaman Nagarajan ◽

Xiangshu Xiao ◽

Smitha Antony ◽

Glenda Kohlhagen ◽

Yves Pommier ◽

...

Keyword(s):

Topoisomerase I ◽

Biological Evaluation ◽

Side Chains ◽

Design Synthesis ◽

Design, synthesis and biological evaluation of 3-substituted indenoisoquinoline derivatives as topoisomerase I inhibitors

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2015.12.014 ◽

2016 ◽

Vol 26 (3) ◽

pp. 1068-1072 ◽

Cited By ~ 3

Author(s):

Qian Zhao ◽

Xi Xu ◽

Zhouling Xie ◽

Xiao Liu ◽

Qidong You ◽

...

Keyword(s):

Topoisomerase I ◽

Biological Evaluation ◽

Design Synthesis ◽

Dibenzo[c,h][1,5]naphthyridinediones as Topoisomerase I Inhibitors: Design, Synthesis, and Biological Evaluation

The Journal of Organic Chemistry ◽

10.1021/jo3006039 ◽

2012 ◽

Vol 77 (11) ◽

pp. 5167-5172 ◽

Cited By ~ 16

Author(s):

Evgeny Kiselev ◽

Nicholas Empey ◽

Keli Agama ◽

Yves Pommier ◽

Mark Cushman

Keyword(s):

Topoisomerase I ◽

Biological Evaluation ◽

Design Synthesis ◽

Synthesis and Biological Evaluation of New Carbohydrate-Substituted Indenoisoquinoline Topoisomerase I Inhibitors and Improved Syntheses of the Experimental Anticancer Agents Indotecan (LMP400) and Indimitecan (LMP776)

Journal of Medicinal Chemistry ◽

10.1021/jm401814y ◽

2014 ◽

Vol 57 (4) ◽

pp. 1495-1512 ◽

Cited By ~ 40

Author(s):

Daniel E. Beck ◽

Keli Agama ◽

Christophe Marchand ◽

Adel Chergui ◽

Yves Pommier ◽

...

Keyword(s):

Anticancer Agents ◽

Topoisomerase I ◽

Biological Evaluation ◽

ChemInform Abstract: Amphimic Acids and Related Long-Chain Fatty Acids as DNA Topoisomerase I Inhibitors from an Australian Sponge, Amphimedon sp.: Isolation, Structure, Synthesis, and Biological Evaluation.

ChemInform ◽

10.1002/chin.199810250 ◽

2010 ◽

Vol 29 (10) ◽

pp. no-no

Author(s):

T. NEMOTO ◽

G. YOSHINO ◽

M. OJIKA ◽

Y. SAKAGAMI

Keyword(s):

Fatty Acids ◽

Topoisomerase I ◽

Biological Evaluation ◽

Dna Topoisomerase I ◽

Long Chain Fatty Acids ◽

Dna Topoisomerase ◽

Structure Synthesis ◽

Synthesis And Biological Evaluation ◽

Long Chain

Amphimic acids and related long-chain fatty acids as DNA topoisomerase I inhibitors from an Australian sponge, Amphimedon sp.: Isolation, structure, synthesis, and biological evaluation

Tetrahedron ◽

10.1016/s0040-4020(97)10099-0 ◽

1997 ◽

Vol 53 (49) ◽

pp. 16699-16710 ◽

Cited By ~ 58

Author(s):

Takayuki Nemoto ◽

Go Yoshino ◽

Makoto Ojika ◽

Youji Sakagami

Keyword(s):

Fatty Acids ◽

Topoisomerase I ◽

Biological Evaluation ◽

Dna Topoisomerase I ◽

Long Chain Fatty Acids ◽

Dna Topoisomerase ◽

Structure Synthesis ◽

Synthesis And Biological Evaluation ◽

Long Chain

Design, synthesis, and biological evaluation of cytotoxic 11-aminoalkenylindenoisoquinoline and 11-diaminoalkenylindenoisoquinoline topoisomerase I inhibitors

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2004.07.027 ◽

2004 ◽

Vol 12 (19) ◽

pp. 5147-5160 ◽

Cited By ~ 31

Author(s):

Xiangshu Xiao ◽

Smitha Antony ◽

Glenda Kohlhagen ◽

Yves Pommier ◽

Mark Cushman

Keyword(s):

Topoisomerase I ◽

Biological Evaluation ◽

Design Synthesis ◽

Design, Synthesis, and Biological Evaluation of Cytotoxic 11-Alkenylindenoisoquinoline Topoisomerase I Inhibitors and Indenoisoquinoline−Camptothecin Hybrids

Journal of Medicinal Chemistry ◽

10.1021/jm0300476 ◽

2003 ◽

Vol 46 (15) ◽

pp. 3275-3282 ◽

Cited By ~ 53

Author(s):

Brian M. Fox ◽

Xiangshu Xiao ◽

Smitha Antony ◽

Glenda Kohlhagen ◽

Yves Pommier ◽

...

Keyword(s):

Topoisomerase I ◽

Biological Evaluation ◽

Design Synthesis ◽